Lymphocytotoxic Antisera of Limited Iso-Specificity
After Skin Grafting in Man

Thorsby, E.; Kissmeyer-Nielsen, F.

doi:10.1159/000464728

Cited by 1 publication

(1 citation statement)

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“…Incompatibility with respect to HLA‐A2 in skin grafts was found to be associated with short survival time (Jurcevic et al ., 2001). Concerning the humoral immune response, A2 − individuals immunized with A2 + tissues preferentially formed anti‐A2 antibodies (Thorsby & Kissmeyer‐Nielsen, 1968). In some bone marrow graft rejections, HLA‐A2 specific restricted killing of Y antigen by women's T cells was reported (Goulmy et al ., 1977).…”

Section: Introductionmentioning

confidence: 99%

HLA‐A2 class I antigens in couples with recurrent spontaneous abortions

Komlos¹,

Klein

Korostishevsky

2007

Int J Immunogenetics

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Class I human leukocyte antigen (HLA) antigens, locus A and B, were typed in fertile and infertile couples in cases where one of the spouses carried the HLA-A2 antigen. HLA-class I typing data were obtained from 282 participants, 63 fertile couples and 78 infertile couples with recurrent spontaneous abortions (RSA). Locus A antigens were grouped into eight broad specificities (A1, A2, A3, A9, A10, A11, A19, A28) and locus B antigens were grouped, according to HLA epitopes, in two classes (BW4 and BW6). Although the number of cases is small, significant differences in the distribution of locus A antigens were found between HLA-A2-positive (A2+) women from fertile and infertile couples. HLA-A3, A11 and A28 cross-reacting antigens were absent in women from fertile couples and present in women from infertile couples. HLA-A19, which is associated with amino acid triplets of low immunogenicity, was significantly more often observed in A2+ fertile than in infertile women. An excess of the BW4 epitope was found in A2(-) husbands from infertile couples compared to fertile ones. The results of this study support the idea that in the presence of the HLA-A2 molecule the distribution of HLA-A and B loci antigens may be different in fertile couples compared to couples with recurrent spontaneous abortions. It can be suggested that the HLA-A2 molecule, in context with specific genotypes, may contribute to the overall maternal immune response in normal and disturbed pregnancy.

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Section: Introductionmentioning

confidence: 99%