Lymphoepithelioma-like Carcinoma of the Breast: A Case Report

Top, Omer Erdinc; Vardar, Enver; Yağcı, Ayşe; Deniz, Senem; Öztürk, Rafet; Zengel, Baha

doi:10.5152/tjbh.2014.1675

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…The clinical characteristics of the previous reports are summarised in Table I. Morphologically, tumour necroses were identified in two patients in the Dadmanesh series as well as in five more cases [5,10,15,19,24]. A lobular variant of LELC-B has been reported by some authors [3,4,7,9] associated with LCIS [3,4,7], pagetoid spread [4], or with atypical lobular hyperplasia [9].…”

Section: Discussionmentioning

confidence: 97%

“…Ductal carcinoma in situ was not identified in any of the previous cases. In three of the cases there was association with sclerosing lymphocytic lobulitis in the surrounding breast parenchyma [6,19,20]. Kurose et al reported glandular differentiation on electron microscopy [10].…”

Section: Discussionmentioning

confidence: 99%

“…Lymphoepithelioma-like carcinoma (LELC) is a poorly differentiated carcinoma occurring outside the nasopharynx, which displays identical histological features to its nasopharyngeal counterpart. It has been reported in several anatomic sites including breast [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25], colon [26], esophagus [27], kidney [28], lacrimal gland [29,30], larynx [31], hepatobiliary system [32,33], lungs [34], major and minor salivary glands [35,36,37,38], orbital adnexa [39], prostate [28], skin [40], stomach [41], thymus [42], thyroid [43], trachea [44], ureter [45], urinary bladder [46], uterine cervix [47], vagina [48], and vulva…”

Section: Introductionmentioning

confidence: 99%

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Lymphoepithelioma-like breast carcinoma

Koufopoulos¹,

Syrios²,

Papanikolaou³

et al. 2018

pjp

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Nasopharyngeal lymphoepithelioma is an undifferentiated carcinoma in a dominated lymphoplasma-histiocyte stroma. Lymphoepithelioma-like carcinoma of the breast is the mammary counterpart of the lymphoepithelioma of the nasopharynx and is characterised by proliferation of poorly differentiated malignant cells within a prominent lymphoid infiltrate. It is a very rare primary carcinoma of the breast first reported in 1994 by Kumar and Kumar. Fewer than 40 cases have been reported in the English literature. In this manuscript a case of lymphoepithelioma-like carcinoma of the breast in a 57-year-old patient is reported along with a literature review on this rare entity.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lymphoepithelioma-like breast carcinoma

Koufopoulos¹,

Syrios²,

Papanikolaou³

et al. 2018

pjp

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“…Lymphoepithelioma-like carcinoma (LELC) is a relatively rare type of nonkeratinizing carcinoma characterized by prominent infiltration of lymphocytes. Although it primarily originates from the nasopharynx, rare cases occurring in other organs (e.g., the liver, breast, bladder, cervix, and lung) have also been previously reported [1][2][3][4][5] . Primary LELC of the lung was first described by Bégin et al [6] in 1987.…”

Section: Introductionmentioning

confidence: 99%

CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review

Yang

Liang

Liu

et al. 2020

WJCC

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BACKGROUNDLymphoepithelioma-like carcinoma (LELC) is a non-keratinizing carcinoma with rich lymphocytic infiltration, which primarily originates from the nasopharynx. Primary lung LELC is a type of lung cancer with a relatively low incidence. Herein, we report a rare case of lung LELC with expression of CD56. We also performed a literature review to summarize the epidemiological, clinical, and prognostic features of this disease. CASE SUMMARYA 51-year-old man was admitted to Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College due to cough and chest pain lasting > 2 mo and 1 wk, respectively. Positron emission tomography-computed tomography and magnetic resonance imaging examinations revealed the presence of a mass in the right upper lobe with enlargement of lymph nodes and multiple bone metastases. According to the results of bronchoscopy and cervical lymph node biopsy, a diagnosis of lung LELC with CD56-positive staining (CD56 + lung LELC) was made. In the literature, 458 cases of lung LELC have been reported. However, only one other case of CD56 + lung LELC has been reported thus far. CONCLUSIONThe mechanism and potential role of CD56 expression in CD56 + lung LELC require further investigation.

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Lymphoepithelioma-Like Carcinoma of the Breast: A Case Report Unveiling Several Clinical and Histopathological Challenges

Aridi

Fawwaz

Kassab

et al. 2018

Case Reports in Surgery

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Lymphoepithelioma-like carcinoma (LELC) of the breast is an extremely rare tumor type. Histologically, it mimics undifferentiated nasopharyngeal carcinoma by demonstrating nests of neoplastic epithelial cells in a background of lymphoplasmacytic infiltrates. This paper reports a 62-year-old female patient with a 3 × 1.5 cm BI-RADS type IV breast mass diagnosed on excisional biopsy as LELC. The tumor is negative for estrogen and progesterone receptors and did not overexpress HER2/neu. Routine tests for clearance before surgery were performed, and patient was managed by a modified radical mastectomy with axillary lymph node dissection showing no residual tumor. Surgical CAse REports (SCARE) guidelines were followed for reporting our case. The rarity of LELC of the breast warrants the establishment and implementation of well-defined guidelines and criteria for diagnosis and management.

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Lymphoepithelioma-like Carcinoma of the Breast: A Case Report

Cited by 5 publications

References 12 publications

Lymphoepithelioma-like breast carcinoma

Lymphoepithelioma-like breast carcinoma

CD56+ lymphoepithelioma-like carcinoma of the lung: A case report and literature review

Lymphoepithelioma-Like Carcinoma of the Breast: A Case Report Unveiling Several Clinical and Histopathological Challenges

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