Lymphoepithelioma-like Carcinoma of the Renal Pelvis: A Case Report and Review of the Literature

Ahn, Hyein; Sim, Jongsung; Kim, Hyunsung; Yi, Kijong; Han, Haegin; Chung, Yun Jae; Rehman, Abdul; Paik, Seung Sam

doi:10.4132/koreanjpathol.2014.48.6.458

Cited by 6 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lymphoepithelioma-like carcinoma (LELC) is a rare high-grade carcinoma that resembles nasopharyngeal lymphoepithelioma and has been reported to occur in other sites of the body such as gastrointestinal tract [ 1 ], liver [ 2 ], lung [ 3 ], skin [ 4 ], uterus [ 5 ], gallbladder [ 6 ], pancreas [ 7 ], kidney [ 8 ], and breast [ 9 ]. First reported in 1991 [ 10 ], LELC of the bladder appears to resemble LELC histologically in the nasopharynx but is actually a variant of urothelial carcinoma and has an incidence of about 1% of all bladder carcinomas [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

et al. 2017

View full text Add to dashboard Cite

BackgroundLymphoepithelioma-like carcinoma (LELC) is a rare high-grade carcinoma that resembles nasopharyngeal lymphoepithelioma and can occur throughout the body. First reported in 1991, bladder LELC has an incidence of about 1% of all bladder carcinomas. Due to its rare occurrence, prognoses and ideal treatment guidelines have not been clearly defined.MethodsA PubMed search was performed using two terms, “lymphoepithelioma-like carcinoma” and “bladder.” Review articles, articles in foreign languages, expression studies, and studies not performed in the bladder were excluded. We report a case of LELC of the bladder including treatment and outcome and performed a systematic review of all 36 available English literatures from 1991 to 2016 including the present case to identify factors affecting disease-free survival.ResultsOne hundred forty cases of bladder LELC were analyzed. The mean age of the patients was 70.1 years ranging from 43 to 90 years with 72% males and 28% females. Pure LELC occurs most often at 46% followed by mixed LELC 28% and predominant LELC 26%. EBV testing was negative in all cases tested. Mean follow-up length for all cases was 33.8 months with no evidence of disease in 62.2%, while 11.1% died of disease, 10.4% alive with metastasis, and 8.2% died without disease. 5.0% of cases had recurrence at an average of 31.3 months. Prognosis is significantly favorable for patients presenting with pure or predominant forms of LELC compared to mixed type (p < 0.0001). The treatment significantly associated with the highest disease mortality and lowest disease-free survival was TURBT alone when compared to any multi-modality treatment (p < 0.01).ConclusionWe conclude that the best treatment modality associated with the highest disease-free survival is multi-modal treatment including radical cystectomy.

show abstract

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Based on these criteria, a final cohort of 18 183 UUT‐UC patients was included in the present analysis. Additionally, the PubMed, Medline, Cochrane, Web of Science, Embase, and Scopus databases were searched to identify relevant studies examining LELC of the upper urinary tract from database inception until March 2022 ( n = 39) [ 8 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. The main search terms included: ‘lymphoepithelioma‐like carcinoma’, ‘ureter’, ‘renal pelvis’, ‘upper tract urothelial carcinoma’, ‘upper urinary tract urothelial carcinoma’, ‘prognosis’, ‘survival’, and ‘case report’.…”

Section: Methodsmentioning

confidence: 99%

Analysis of genetic profiling, pathomics signature, and prognostic features of primary lymphoepithelioma‐like carcinoma of the renal pelvis

et al. 2022

View full text Add to dashboard Cite

carcinogenesis of primary LELC may be due to different genetic variations, including single-nucleotide variants, insertion and deletions, structural variations, and repeat regions, which may provide the basis for clinical diagnosis and treatment. The prognosis of LELC in the upper urinary tract is similar to that of UUT-UC. We suggest that the focal subtype can serve as a prognostic factor for LELC of the upper urinary tract; however, further studies are required to confirm this.

show abstract

“…The association with EBV infection in LELC is different in various locations and in different geographic regions. EBV positivity has been described in tumours of lung, stomach, thymus, and salivary gland [2,3,4,5], but it has not been demonstrated in cases of LELC occurring in the urinary bladder, renal pelvis, breast, and in the female genital tract [6,7,8,9,10]. It has been suggested that EBV positivity is related to a direct organ exposure to the external environment, and EBV negativity is more common in internal organs [11].…”

Section: Introductionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma of the endometrium: Case report of a rare tumour with comprehensive immunohistochemical and molecular analysis

Němejcová¹,

Hájková²,

Tichá³

et al. 2018

pjp

View full text Add to dashboard Cite

We are reporting a case of endometrial lymphoepithelioma-like carcinoma (LELC) in a 63-year-old female. Microscopically, the tumor consisted of groups of tumor cells surrounded by dense lymphoplasmacytic infiltrate. Immunohistochemically, the tumour cells were positive for cytokeratins AE1/AE3, EMA, PAX8, p16, and estrogen receptors. Protein p53 showed an aberrant type of expression. Molecular genetic analysis revealed mutations in the TP53 and PIKP53CA genes. Based on our results, we believe that the tumor represents an unusual morphological variant of endometrial serous carcinoma.To the best of our knowledge, only six cases of LELC arising in endometrium have been reported in literature to date.

show abstract

Lymphoepithelioma-like Carcinoma of the Renal Pelvis: A Case Report and Review of the Literature

Cited by 6 publications

References 9 publications

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

Analysis of genetic profiling, pathomics signature, and prognostic features of primary lymphoepithelioma‐like carcinoma of the renal pelvis

Lymphoepithelioma-like carcinoma of the endometrium: Case report of a rare tumour with comprehensive immunohistochemical and molecular analysis

Contact Info

Product

Resources

About