Lymphoepithelioma-like Carcinoma of the Skin

Cavalieri, Silvia; Feliciani, Claudio; Massi, Guido; Addolorato, Giovanni; Gasbarrini, Giovanni; Amerio, Paolo; Rotoli, M

doi:10.1177/039463200702000424

Cited by 13 publications

(13 citation statements)

References 13 publications

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Section: Discussionmentioning

confidence: 99%

“…It is slow growing and generally asymptomatic and has usually been present in the patient from months to years [7]. Histologically, it is found in the mid to deep dermis and is nonecapsulated [7]. Histologically, LELCS is characterized by lobules, or nests of polygonal epithelioid cells surrounded by a dense infiltrate of T and B lymphocytes [5, 8] (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

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Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Gille

Miles

Mitchell

2012

Case Reports in Oncological Medicine

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Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare cutaneous neoplasm microscopically similar to undifferentiated nasopharyngeal carcinoma. It is typically nonaggressive and is treated with wide local excision. However, we present a case of a patient with a regional recurrence and more aggressive LELCS with perineural invasion and positive margins for which he was treated with wide local excision followed by chemoradiation. We discuss the use of chemoradiation for this patient and review the literature, specifically pertaining to treatment of more aggressive cases of LELCS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Gille

Miles

Mitchell

2012

Case Reports in Oncological Medicine

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“…LELCS is a slow indolent growing epithelial neoplasm with moderate tendency to metastasize 8 . The size of the lesion varies among locations and reports, however the majority average between 2 to 3 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Skin: Case Report and Approach to Surgical Pathology Sign Out

Abedi¹,

Salama

Alowami

2013

Rare Tumors

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Lymphoepithelioma-like carcinoma of the skin (LELCS) is a rare and poorly differentiated variant of squamous cell carcinoma. The lesion is histologically identical to undifferentiated nasopharyngeal carcinoma (lymphoepithelioma), but with Epstein-Barr virus involvement documented rarely. The first case of LELCS was described in 1988 by Swanson et al. and since there has been less than a total of 60 cases documented. This case review discusses a 87 year old man who presented to his primary care physician with a 2.5 cm solitary ulcerated nodular lesion on his right chest for two weeks. The patient ultimately had the lesion excised and sent for histological examination. The microscopic examination, ancillary studies used and differential diagnosis considered are discussed in detail in the following report. This case review aims to provide insight and approach to a rare cutaneous neoplasm, with the conclusions supporting a theory that LELCS is a separate entity from lymphoepithelioma.

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“…Lymphoepithelioma-like carcinoma has been reported in a variety of anatomic sites that include skin [13][14][15][16] , lacrimal and salivary glands 17,18 , thyroid gland 19 , thymus 20 , breast 3 , lung 21 , esophagus 22 , stomach 23 , colon 24 , hepatobiliary system 25,26 , renal pelvis [27][28][29][30] , ureter 28 , kidney 27 , bladder 31 , prostate 27 , uterine cervix 32 , vulva 33,34 , and vagina 35 . The foregoing sites typically have better outcomes than are seen with aggressive nasopharyngeal tumours; however, they do demonstrate the potential for local spread, angioinvasion, and metastasis to lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Breast: A Diagnostic and Therapeutic Challenge

et al. 2012

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also present an overview of our patient's proposed treatment in the context of the 16 other reported lelc cases. CASE PRESENTATIONA 55-year-old postmenopausal woman originally from Ghana presented with a 4-week history of left breast tenderness and an upper outer quadrant mobile breast mass. She had been mammographically screened, with the most recent mammogram (performed 1 year before her presentation) having demonstrated no abnormalities. Her past medical history was unremarkable, with a surgical history of Cesarean section, tubal ligation, and hernia repair. She was gravida 2, para 2, with menopause having occurred at age 53. On systems review, she denied fevers, chills, or night sweats. No weight loss was reported, and she was asymptomatic but for left breast tenderness.Physical examination revealed no cervical or axillary adenopathy, but was significant for a diffusely swollen left breast with a discrete, mobile 4-cm mass. The exam was otherwise noncontributory.Mammography revealed a 3-to 4-cm upper outer quadrant density with spot compression views showing lobulated margins. No evidence of calcifications was noted. Breast ultrasonography showed a 4.3×3.5×2.6-cm lobulated, poorly marginated, hypoechoic solid mass. Computed tomography of the thorax, abdomen, and pelvis showed no evidence of distant metastases and the presence of an 8-cm left breast mass with a uniform low-density component (Figure 1).Fine-needle aspirate yielded a cellular specimen noteworthy for single and groups of abnormal elongated cells with visible nucleoli presenting together with lymphocytes and plasma cells. A bone marrow biopsy revealed normocellular marrow with no evidence of lymphoproliferative disorder.An excisional biopsy was followed by 3 successive pathology reviews. The initial consultant ABSTRACTWe present a patient with lymphoepithelioma-like carcinoma (lelc) of the breast whose diagnosis is illustrative of the pathology nuances that must be taken into account to successfully reach correct identification of the disease. We also present an overview of our patient's proposed treatment in the context of 16 other reported lelc cases. Although lelc cases are rare, a sufficient number have been reported to discern the natural history of this pathologic entity and to undertake a review of those cases and of the application of oncologic first principles in their management. Given the potential for locoregional spread and distant metastases in lelc, adjuvant therapy has a role in the treatment of this entity.

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Lymphoepithelioma-like Carcinoma of the Skin

Cited by 13 publications

References 13 publications

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Lymphoepithelioma-Like Carcinoma of the Skin Treated with Wide Local Excision and Chemoradiation Therapy: A Case Report and Review of the Literature

Lymphoepithelioma-Like Carcinoma of the Skin: Case Report and Approach to Surgical Pathology Sign Out

Lymphoepithelioma-Like Carcinoma of the Breast: A Diagnostic and Therapeutic Challenge

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