Lymphoepithelioma-like Carcinoma of the Urinary Bladder

Amin, Mahul B.; Ro, Jae Y.; Lee, Kwang M.; Ordóñez, Nelson G.; Dinney, Collin P.; Gulley, Margaret L.; Ayala, Alberto G.

doi:10.1097/00000478-199405000-00005

Cited by 186 publications

(189 citation statements)

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“…31 Most reports, consisting of either single cases or very small series, had suggested a favourable prognosis if lymphepithelioma-like carcinoma was the predominant pattern, as chemotherapy seemed to produce responses. [32][33][34] However, the largest series of 28 cases from Tamas and colleagues failed to show an improved prognosis for this variant of urothelial carcinoma. They noted a similar prognosis when compared with patients with conventional urothelial carcinoma who underwent cystectomy.…”

Section: Micropapillary Carcinomamentioning

confidence: 99%

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Chalasani

Chin

Izawa

2013

CUAJ

161

113

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Bladder cancer can be classified histologically as urothelial or non-urothelial. Urothelial cancer has a propensity for divergent differentiation, which has increasingly been recognized in recent years due to heightened awareness and improved immunohistochemistry techniques. Furthermore, the recent World Health Organization classification of urothelial cancers improved clarity on this issue, with its listing of 13 histologic variants of urothelial cancer. The divergent differentiation patterns include, amongst others, squamous, glandular, micropapillary, nested, lymphepithelioma-like, plasmacytoid and sarcomatoid variants of urothelial cancer. Attempts to quantify the amount of divergent differentiation present, such as using the nonconventional differentiation number, have been made recently, which will improve the ability to compare publications from different centres. Genetic-based studies have indicated that the histologic variants of urothelial cancer arise from a common clonal precursor. Mostly, the current evidence suggests that urothelial cancer with divergent differentiation has a worse prognosis when compared with pure urothelial cancer. This article will review the current literature on variant histologies of urothelial cancer, and well as new developments in pure squamous cell carcinoma, small cell carcinoma and adenocarcinoma of the bladder.

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Section: Micropapillary Carcinomamentioning

confidence: 99%

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Chalasani

Chin

Izawa

2013

CUAJ

161

113

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“…In a small number of patients with pure and predominant LELC treated with transurethral resection of bladder tumor (TUR) and chemotherapy only, no evidence of disease was achieved in a follow-up period between 2 to 18 years (8)(9)(10). In most of the reported cases, the platinum-based chemotherapies were performed in the treatment of both locally advanced and metastatic disease (9). However, as with other variants of bladder tumors, there are no clear guidelines for the treatment of LELC.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore three types of LELC are described: pure (100%), predominant (> 50%), or focal (< 50%) (3). Their occurrence in the urinary system is very rare and in fact, the reported incidence of LELC in the bladder is between 0.4% and 1.3% of all bladder carcinomas (4).…”

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confidence: 99%

Lymphoepithelioma-like carcinoma of the bladder: A case report.

Stamatiou

Christopoulos

Tsavari

et al. 2016

Arch Ital Urol Androl

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Lymphoepithelioma is a rare histological type of low differentiated carcinoma of the nasopharyngeal region characterized by marked infiltration of lymphocytes in the area involved by tumor. However, carcinomas with this peculiar morphologic feature have been also described in various anatomic locations and they are generally designated «lymphoepithelioma-like carcinomas». Those of the urinary bladder are uncommon as they account of 0.4%-1.3% of all bladder carcinomas. They may coexist with the conventional urothelial carcinoma. Given their rarity, there is poor information regarding their behaviour. Here we present a new case of lymphoepithelioma-like carcinoma in the bladder and we discuss its characteristics and prognosis.

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“…7,8 Amin and colleagues classified LELC of the urinary bladder into 3 categories: pure (100% LELC), predominant (more than 50% LELC) and focal (less than 50% LELC). 9 Where less than 100% LELC is seen, the remainder of the tumour usually comprises classical urothelial carcinoma. Porcaro and colleagues conducted a literature review of 43 patients with LELC of the urinary bladder; they found that the survival rate was 93% for pure LELC (mean follow-up 48.1 months), 93% for predominant LELC (mean follow-up 32 months), and 0% for focal LELC (mean follow-up 30.3 months).…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-like carcinoma of the renal pelvis: Pathological and therapeutic implications

Modi

Beckley

Bhattarai

et al. 2013

CUAJ

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A 75-year-old woman presented with a presumed urothelial carcinoma of the right renal pelvis. A radical nephroureterectomy was carried out and histological analysis of the specimen revealed lymphoepithelioma-like carcinoma. This is the seventh reported case of this normally nasopharyngeal tumour found in the renal pelvis. These tumours have a distinct histological appearance comprising sheets of undifferentiated syncytial cells on a background of lymphoid stroma. We review the pathological features of lymphoepithelioma-like carcinoma and make arguments for managing these tumours in a similar way to urothelial carcinoma.

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Lymphoepithelioma-like Carcinoma of the Urinary Bladder

Cited by 186 publications

References 0 publications

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

Lymphoepithelioma-like carcinoma of the bladder: A case report.

Lymphoepithelioma-like carcinoma of the renal pelvis: Pathological and therapeutic implications

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