Lymphoepithelioma-like Carcinoma of the Uterine Cervix

Abstract

Lymphoepithelioma-like carcinomas have been reported outside the nasopharynx in many sites, including the uterine cervix. The association with the Epstein-Barr virus in the latter site is still controversial. To date, Epstein-Barr virus genome has only been demonstrated in Asian patients. We report a case of lymphoepithelioma-like carcinoma of the uterine cervix in a white woman in whom the Epstein-Barr virus infection was tested for by in situ hybridization and polymerase chain reaction. The results of both techniques were negative. Our case and a review of the literature support the contention that cervical lymphoepithelioma-like carcinoma is not associated with Epstein-Barr virus infection in non-Asian patients.

A fertility-sparing surgery in lymphoepithelioma-like carcinomas of the uterine cervix: A case report

“…Radical hysterectomy is a surgical procedure that Radiotherapy IIB(4) Takai et al [6] Japan [2] Netherlands 1 44 Negative 16, 45 IB1 RH, BPLND None Table 1. Reported cases of LELC of cervix in the literature Martorell et al [8] Spain [9] Spain 1 44 Positive Not done IB1 RH, BPLND No report Saylam et al [10] Belgium 1 72 Not done 18 IB1 RH, BPLND None Takebayashi et al [11] Japan 1 45 Negative Not done IB3 RH Radiotherapy Table 1. Reported cases of LELC of cervix in the literature Kaul et al [12] India 1 42 Not done Not done IB1 RH, BPLND No report Kim et al [13] Korea 1 57 Negative Negative IB1 RH, BSO, BPLND, PALND, appendectomy Paclitaxel + cisplatin Ki et al [14] Korea 1 63 Positive 16 IB1 RH, BSO, BPLND, appendectomy None Yoo et al [15] Korea 1 55 Not done Not done IB1 RH, BSO, BPLND None Yun et al [15] Korea 1 45 Negative Negative IB1 RH, BPLND None BPLND = bilateral pelvic lymph node dissection, BSO: Bilateral salpingo-oophorectomy, EBV = Epstein-Barr virus, FIGO stage = 2018 FIGO Staging System for Uterine Cervical Cancer, HPV = human papilloma virus, PALND = para-aortic lymph node dissection, RH = radical hysterectomy.…”

“…[15] However, there are no definite findings that EBV acts as the main factor in cervical cancer in Caucasians. [9] It can be assumed that race and ethnicity can influence the role of EBV gene as an oncogenic factor. [5] With regards to HPV, an association with HPV infection has also been postulated.…”