Lymphoepithelioma-like Hepatocellular Carcinoma: a Case Report and Review of Literature

Sweed, Dina; Sultan, Mervat M.; Mosbeh, Asmaa; Fayed, Yahya; Abdelsameea, Eman; Ehsan, Nermine; Abdel‐Rahman, Mohamed H.; Waked, Imam

doi:10.1007/s12029-021-00757-0

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Only one case was reported in our institute, a 42-year-old male who was positive for HCV [14]. A follow-up of the patient revealed that he has been recurrence-free for the past 60 months (Fig.…”

Section: Lymphoepithelioma-like Carcinoma (Lel-hcc)mentioning

confidence: 98%

The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt

Sweed

Moaz

et al. 2022

World J Surg Onc

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Background Hepatocellular carcinoma (HCC) remains a major health problem despite the emergence of several preventive and therapeutic modalities. HCC has heterogeneous and wide morpho-molecular patterns, resulting in unique clinical and prognostic criteria. Therefore, we aimed to study the clinical and pathological criteria of HCC to update the morpho-molecular classifications and provide a guide to the diagnosis of this disease. Methods Five hundred thirty pathologically analyzed HCC cases were included in this study. The clinical and survival data of these cases were collected. Results Hepatitis C virus is still the dominant cause of HCC in Egypt. Post-direct-acting antiviral agent HCC showed an aggressive course compared to interferon-related HCC. Old age, male gender, elevated alpha-fetoprotein level, tumor size, and background liver were important prognostic parameters. Special HCC variants have characteristic clinical, laboratory, radiological, prognostic, and survival data. Tumor-infiltrating lymphocytes rather than neutrophil-rich HCC have an excellent prognosis. Conclusions HCC is a heterogenous tumor with diverse clinical, pathological, and prognostic parameters. Incorporating the clinicopathological profile per specific subtype is essential in the treatment decision of patients with HCC. Trial registration This was a retrospective study that included 530 HCC cases eligible for analysis. The cases were obtained from the archives of the Pathology Department, during the period between January 2010 and December 2019. Clinical and survival data were collected from the patients’ medical records after approval by the institutional review board (IRB No. 246/2021) of Liver National Institute, Menoufia University. The research followed the guidelines outlined in the Declaration of Helsinki and registered on ClinicalTrials.gov (NCT05047146).

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Section: Lymphoepithelioma-like Carcinoma (Lel-hcc)mentioning

confidence: 98%

The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt

Sweed

Moaz

et al. 2022

World J Surg Onc

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“…Previous studies have shown that the expression of cytokeratin-7 has little value in the differential diagnosis of metastatic carcinoma (17)(18)(19). At the same time, in some tumors such as prostate and hepatocellular carcinoma, the absence of cytokeratin-7 is of more excellent diagnostic value (20)(21)(22). Cytokeratin-20 occurs mainly in colorectal carcinomas and one-third of gastric adenocarcinomas (23)(24)(25).…”

Section: B) Cytokeratin-7mentioning

confidence: 99%

Determining the relationship between cytokeratin expression and prognostic factors in human gastric cancer

Zheng

Chen

Liu

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Determining the prognosis of gastric cancer is the most crucial step in the treatment process. Cytokeratins are intermediate filaments found in the intracellular structure of epithelial tissues. Recent researches have focused on determining the relationship between the expression of cytokeratins and the degree and prognosis of tumors. This study aimed to investigate the relationship between the incidence of cytokeratin-20 and cytokeratin-7 in patients with gastric carcinoma with factors influencing the prognosis. In this regard, the study was conducted cross-sectional. The expression of cytokeratin-20 and cytokeratin-7 was evaluated on 50 gastric adenocarcinoma specimens with different degrees of differentiation by the immunohistochemical method. We determined the relationship between the incidence of cytokeratin-20 and cytokeratin-7 with factors affecting the prognosis of patients, including the degree of differentiation of gastric cancer tissue, lymph node involvement, and the depth of tumor invasion. Data were statistically analyzed by Chi-square and Spearman tests. The results showed a statistically inverse relationship between the incidence of cytokeratin-20 and cytokeratin-7 with the degree of tissue differentiation and lymph node involvement in gastric cancer. Although there was a statistically significant relationship between the incidence of tissue invasion in gastric cancer and the incidence of cytokeratin-7, there was no association between the incidence of cytokeratin-20 and tissue invasion. In general, decreased cytokeratin-20 and cytokeratin-7 are associated with decreased tissue differentiation and increased lymph node involvement.

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Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma

Jia

Guo²,

Liu

et al. 2023

J Cancer Res Clin Oncol

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Lymphoepithelioma-like Hepatocellular Carcinoma: a Case Report and Review of Literature

Cited by 4 publications

References 36 publications

The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt

The clinicopathological and prognostic factors of hepatocellular carcinoma: a 10-year tertiary center experience in Egypt

Determining the relationship between cytokeratin expression and prognostic factors in human gastric cancer

Single-center experience in the diagnosis and treatment of lymphoepithelioma-like hepatic carcinoma

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