Lymphogranuloma venereum: an emerging problem in Poland

Smolarczyk, Katarzyna; Młynarczyk-Bonikowska, Beata; Majewski, Sławomir; Rudnicka, Ewa; Unemo, Magnus; Fiedor, Piotr

doi:10.5114/ada.2020.101466

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…In 2018, two additional cases of C. trachomatis L2b were confirmed in MSM men aged 47 and 36, HIV negative and without concomitant sexually transmitted diseases. Both patients had enlarged inguinal lymph nodes and lower gastrointestinal complaints such as anal and rectal mucosa ulcerations and bleeding [15]. All patients were treated with doxycycline in accordance with the current recommendations, with a satisfactory therapeutic effect.…”

Section: Przypadekmentioning

confidence: 99%

“…W 2018 roku potwierdzono dwa dodatkowe przypadki C. trachomatis L2b u mężczyzn MSM w wieku 47 lat i 36 lat, HIVujemnych oraz bez współistniejących chorób przenoszonych drogą płciową. U obu pacjentów stwierdzono powiększone węzły chłonne pachwinowe oraz dolegliwości z dolnego odcinka przewodu pokarmowego w postaci owrzodzeń śluzówki odbytu i odbytnicy oraz krwawień [15]. U wszystkich pacjentów włączono leczenie doksycykliną zgodnie z obowiązującymi rekomendacjami z zadowalającym efektem terapeutycznym.…”

Section: Dotychczas Opisano W Piśmiennictwie 3 Przypadkiunclassified

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Lymphogranuloma venereum – report of cases, review and presentation of European diagnostic and treatment guidelines

Kobusiewicz¹,

Dominiak²,

Bienias³

et al. 2021

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Introduction: Lymphogranuloma venereum is a sexually transmitted disease caused by Chlamydia trachomatis L1-3. There has been an increase in the incidence of lymphogranuloma venereum among homosexual men who have sex with men (MSM) in recent years. Objective: To present two cases of lymphogranuloma venereum patients with different clinical manifestations, and to review the literature. Case reports: A 26-year-old patient was admitted to the Department of Dermatology because of erythematous changes in the groin and lower abdomen The patient was diagnosed with lymphogranuloma venereum. Due to the lack of clinical improvement during the treatment with doxycycline, the treatment was modified to include rifampicin, resulting in the resolution of lesions. A 24-year-old MSM patient was admitted to the Department of Dermatology for the treatment of syphilis and HIV infection detected in the gastroenterological department and diagnosed because of intestinal ailments. Due to pelvic lymphadenopathy, an examination for C. trachomatis was performed to confirm infection. Treatment with doxycycline was initiated, resulting in relief of intestinal ailments. Conclusions: Due to the rarity and diverse morphology of lesions, LGV is a diagnostic and therapeutic challenge. streszczenie Wprowadzenie: Ziarnica weneryczna pachwin jest chorobą przenoszoną drogą płciową, wywołaną przez Chlamydia trachomatis L1-3. W ostatnich latach obserwuje się wzrost liczby zachorowań na ziarnicę weneryczną pachwin wśród homoseksualnych mężczyzn (men who have sex with men -MSM). Cel pracy: Przedstawienie dwóch przypadków pacjentów z ziarnicą weneryczną pachwin o różnym obrazie klinicznym oraz przegląd piś miennictwa. Opisy przypadków: Pacjent 26letni został przyjęty do Kliniki Dermatologii z powodu guzowatych zmian rumieniowych w obrębie pachwin i podbrzusza, u którego zdiagnozowano ziarnicę weneryczną pachwin.

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Section: Przypadekmentioning

confidence: 99%

Section: Dotychczas Opisano W Piśmiennictwie 3 Przypadkiunclassified

Lymphogranuloma venereum – report of cases, review and presentation of European diagnostic and treatment guidelines

Kobusiewicz¹,

Dominiak²,

Bienias³

et al. 2021

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“…In 2003, endemic cases of LGV proctitis and proctocolitis were reported in Europe, clearly associated to HIV-positive men who have sex with men (MSM) ( 10 , 11 ). Since then, similar LGV cases have been increasingly reported mainly in the MSM community of metropolitan areas in Europe, the USA, Canada and Australia ( 12 – 16 ). Interestingly, the ongoing epidemics of LGV in developed countries displays particular epidemiologic features, including a strong association to MSM and HIV co-infection, proctitis sometimes mimicking Crohn's disease symptoms as the main clinical finding, a significant proportion of asymptomatic cases likely contributing to LGV transmission and, surprisingly, a markedly increased proportion of anorectal compared to genital infections ( 17 – 21 ).…”

Section: Introductionmentioning

confidence: 95%

Chronic epididymitis due to Chlamydia trachomatis LGV-L2 in an HIV-negative heterosexual patient: a case report

Paira

Olmedo

Olivera

et al. 2023

Front. Public Health

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Chlamydia trachomatis is an obligate intracellular pathogen and the leading bacterial cause of sexually transmitted infections worldwide. Chlamydia trachomatis genovars L1–L3 are responsible for lymphogranuloma venereum (LGV), an invasive sexually transmitted disease endemic in tropical and subtropical regions of Africa, South America, the Caribbean, India and South East Asia. The typical signs and symptoms of C. trachomatis LGV urogenital infections in men include herpetiform ulcers, inguinal buboes, and/or lymphadenopathies. Since 2003, endemic cases of proctitis and proctocolitis caused by C. trachomatis LGV emerged in Europe, mainly in HIV-positive men who have sex with men (MSM). Scarce data have been reported about unusual clinical presentations of C. trachomatis LGV urogenital infections. Herein, we report a case of a 36-year-old heterosexual, HIV-negative male declaring he did not have sex with men or trans women, who presented to the Urology and Andrology outpatient clinic of a healthcare center from Cordoba, Argentina, with intermittent testicular pain over the preceding 6 months. Doppler ultrasound indicated right epididymitis and funiculitis. Out of 17 sexually transmitted infections (STIs) investigated, a positive result was obtained only for C. trachomatis. Also, semen analysis revealed oligoasthenozoospermia, reduced sperm viability as well as increased sperm DNA fragmentation and necrosis, together with augmented reactive oxygen species (ROS) levels and the presence of anti-sperm IgG autoantibodies. In this context, doxycycline 100 mg/12 h for 45 days was prescribed. A post-treatment control documented microbiological cure along with resolution of clinical signs and symptoms and improved semen quality. Strikingly, sequencing of the ompA gene revealed C. trachomatis LGV L2 as the causative uropathogen. Remarkably, the patient did not present the typical signs and symptoms of LGV. Instead, the infection associated with chronic testicular pain, semen inflammation and markedly reduced sperm quality. To our knowledge, this is the first reported evidence of chronic epididymitis due to C. trachomatis LGV L2 infection in an HIV-negative heterosexual man. These findings constitute important and valuable information for researchers and practitioners and highlight that C. trachomatis LGV-L2 should be considered as putative etiologic agent of chronic epididymitis, even in the absence of the typical LGV signs and symptoms.

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The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility

Smolarczyk

Młynarczyk-Bonikowska

Rudnicka

et al. 2021

IJMS

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Sexually transmitted infections (STIs) caused by Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium are a common cause of pelvic inflammatory disease (PID) which can lead to tubal factor infertility (TFI). TFI is one of the most common causes of infertility, accounting for 30% of female fertility problems. STIs can also have an impact on pregnancy, leading to adverse pregnancy outcomes. Escalating antibiotic resistance in Neisseria gonorrhoeae and Mycoplasma genitalium represents a significant problem and can be therapeutically challenging. We present a comprehensive review of the current treatment options, as well as the molecular approach to this subject. We have given special attention to molecular epidemiology, molecular diagnostics, current and new treatments, and drug resistance.

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Lymphogranuloma venereum: an emerging problem in Poland

Cited by 3 publications

References 37 publications

Lymphogranuloma venereum – report of cases, review and presentation of European diagnostic and treatment guidelines

Lymphogranuloma venereum – report of cases, review and presentation of European diagnostic and treatment guidelines

Chronic epididymitis due to Chlamydia trachomatis LGV-L2 in an HIV-negative heterosexual patient: a case report

The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility

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