Lymphoid System

Raskin, Rose E.

doi:10.1016/b978-141604985-2.50009-8

Cited by 24 publications

(35 citation statements)

References 65 publications

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“…Although no thymic epithelial cells could be detected in the FNA smears, the predominance of small mature lymphocytes intermingled with fewer inflammatory mast cells was highly suggestive of thymoma and, particularly, of its lymphocyte-predomimant form (Day 1997, Raskin 2001 is usually of the lymphoblastic or histiocytic morphologic type and it does not feature a mast cell infiltrate (Day 1997). However, differentiating a lymphocytepredominant thymoma in the absence of epithelial or mast cells from a small-cell lymphoma on a cytological basis may be challenging, warranting histopathological examination to evaluate the tissue architecture (Day 1997, Rogers 2001).…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic exfoliative erythroderma in a cat with thymoma

Kasabalis

Mylonakis

Patsikas

et al. 2017

J Hellenic Vet Med Soc

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A 14-year-old domestic shorthair cat was admitted with a 2-month history of excessive body weight loss and generalized exfoliative dermatitis with erythroderma. Radiographic and ultrasonographic examination revealed a cranioventral cavitary mass within the anterior mediastinum. An ultrasound-guided fine needle aspiration cytology from the mass revealed numerous small mature lymphocytes intermingled with much fewer inflammatory mast cells. These findings, along with a cellpoor interface and mixed cell dermatitis demonstrated on skin histopathology, made the diagnosis of paraneoplastic exfoliative dermatitis straightforward. This uncommon case illustrates the relative value of keratosebborheic skin disease as a useful indicator of an internal malignancy in the cat.

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Section: Discussionmentioning

confidence: 99%

Paraneoplastic exfoliative erythroderma in a cat with thymoma

Kasabalis

Mylonakis

Patsikas

et al. 2017

J Hellenic Vet Med Soc

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“…Με βάση κυτταρολογικά κριτήρια η λεμφαδενοπά θεια μπορεί να χαρακτηριστεί υπερπλαστική, φλεγμο νώδης ή νεοπλασματική, ενώ η μυελοειδής μεταπλασία του λεμφογαγγλίου εμφανίζεται σπάνια (Raskin 2001).…”

Section: κυτταρολογικη εκτιμηση του μη φυσιολογικου λεμφογαγγλιουunclassified

“…Η κοκκιωματώδης λεμφαδενίτιδα (Εικόνα 4) χαρα κτηρίζεται από την αύξηση των μακροφάγων (>3% των ΕΚ), ενώ η πυοκοκκιωματώδης φλεγμονή προϋπο θέτει και την ταυτόχρονη αύξηση των ουδετερόφιλων (Raskin 2001). Στα συχνότερα αίτια περιλαμβάνονται οι συστηματικές μυκητιάσεις (π.χ.…”

Section: Taylor and Baker 2001 Dunn And Gerber 2005)unclassified

“…σιτευτικά), υποδηλώνουν μεταστατική λεμφαδε-νοπάθεια εφόσον πληρούνται 3 τουλάχιστον μορφο λογικά κριτήρια της κακοήθειας (Dungan 1999, Villiers 2003. Η μεταστατική λεμ-φαδενοπάθεια, στην οποία μπορεί να παρατηρηθεί και υπερπλασία ή φλεγμονή (Raskin 2001), εκφράζεται κυρίως από τα (αδενο) καρκινώματα (Εικόνα 6), το μαστοκΰττωμα (Εικόνα 7), το μελάνωμα και το ακαν-θοκυτταρικό καρκίνωμα, ενώ οι μεταστάσεις είναι λι γότερο συχνές στα σαρκώματα και στο αφροδίσιο με ταδοτικό νεόπλασμα (Εικόνα 8) , Papazoglou et al 2001. Τα καρκινώματα συνήθως χα ρακτηρίζονται από την παρουσία ομάδων (Εικόνα 6), ενώ το μαστοκΰττωμα, το μελάνωμα και τα σαρκώμα τα χαρακτηρίζονται από μεμονωμένα νεοπλασματικά κύτταρα (Villiers 2003).…”

Section: νεοπλασματική λεμφαδενοπάθειαunclassified

“…Η μετάσταση μπορεί να τεκ μηριωθεί εφόσον πληρούνται τα περισσότερα κριτή ρια της κακοήθειας (Villiers 2003). Τα κύτταρα του με λανώματος θα πρέπει να διαφοροποιούνται από τα με-λανινοφάγα και τα αιμοσιδηρινοφάγα κύτταρα (Raskin 2001). Όταν η κλινική υποψία για μεταστατική λεμφα-δενοπάθεια είναι ισχυρή, το αρνητικό αποτέλεσμα της κυτταρολογικής εξέτασης δεν μπορεί σε καμία περί πτωση να την αποκλείσει (Langenbach et al 2001).…”

Section: νεοπλασματική λεμφαδενοπάθειαunclassified

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Lymph node cytology in the dog and cat

Mylonakis

Koutinas

Kritsepi‐Konstantinou

2017

J Hellenic Vet Med Soc

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Lymph node (LN) cytology, a cost-effective and highly rewarding diagnostic technique, is performed routinely in the everyday practice. Localised or generalised lymphadenomegaly and clinical staging of malignant tumors comprise the main indications of this valuable diagnostic modality. The superficial and easily palpated submandibular, prescapular and popliteal LN can be easily positioned, while internal LN (i.e. mediastinal, mesenteric, sublumbar) may necessitate a surgical exploration or ultrasound guidance. Fine-needle biopsy and imprint smears from excised LN are the most common techniques to obtain the necessary material. Small lymphocytes constitute more than 80% of the normal LN population, with medium and large lymphocytes making up approximately the 5-15% of it. The occasional presence of plasma and mast cells, neutrophils, eosinophils and macrophages can also be noticed. Lymphadenomegaly, either localised or generalised, is mainly due to hyperplasia, inflammation or neoplasia. Hyperplastic LN may appear normal cytologically, but typically, small lymphocytes predominate (>50% of nucleated cells [NC]), in the context of a moderate increase of medium/large lymphocytes (<20%of NC) and plasma cells (>5% of NC). Hyperplastic lymphadenopathy is indicative of a lymphoid proliferation secondary to a local (e.g. deep staphylococcal pyoderma) or generalised (e.g. leishmaniosis) antigenic stimulation. In primary or secondary lymphadenitis, LN are infiltrated by increased numbers of inflammatory cells, the predominance of which define the neutrophilic or purulent, eosinophilic, granulomatous or pyogranulomatous inflammation. Bacterial (e.g. Mycobacterium sp.), fungal (e.g. Histoplasma capsulatum) and protozoal (e.g. Leishmania infantum) infections, represent the leading etiologies of canine and feline lymphadenitis. In lymphoma, the most common neoplastic lymphadenopathy in both animal species, the predominance of medium and large (> 50% of NC) immature lymphocytes is observed. Metastatic neoplasia can be documented when non-lymphoid malignant cells (i.e. epithelial, mesenchymal) or increased numbers of normally present cells (i.e. mast cells), also bearing malignant features, are detected on LN cytology. Failure to establish a definitive diagnosis on LN cytology warrants a surgical biopsy and histopathology.

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Spleen

Seelig¹

2020

Veterinary Cytology

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Lymphoid System

Cited by 24 publications

References 65 publications

Paraneoplastic exfoliative erythroderma in a cat with thymoma

Paraneoplastic exfoliative erythroderma in a cat with thymoma

Lymph node cytology in the dog and cat

Spleen

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