Lymphoma in Macaques: Association with Virus of Human T Lymphotrophic Family

Homma, Takao; Kanki, Phyllis J.; King, Norval W.; Hunt, Ronald D.; O’Connell, Mark; Letvin, Norman L.; Daniel, M. D.; Desrosiers, R. C.; Yang, Czau‐Siung; Essex, Max

doi:10.1126/science.6087453

Cited by 130 publications

(66 citation statements)

References 26 publications

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“…Early studies tested for antibodies specific for HTLV-1 membrane antigens in macaques with malignant lymphoma (Homma et al, 1984;Kanki et al, 1985). An experimentally HTLV-1-inoculated rhesus macaque developed arthritis, uveitis, and polymyositis (Beilke et al, 1996).…”

Section: Non-human Primate Modelsmentioning

confidence: 99%

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

2005

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Over the past 25 years, animal models of human T-lymphotropic virus type 1 (HTLV-1) infection and transformation have provided critical knowledge about viral and host factors in adult T-cell leukemia/lymphoma (ATL). The virus consistently infects rabbits, some non-human primates, and to a lesser extent rats. In addition to providing fundamental concepts in viral transmission and immune responses against HTLV-1 infection, these models have provided new information about the role of viral proteins in carcinogenesis. Mice and rats, in particular immunodeficient strains, are useful models to assess immunologic parameters mediating tumor outgrowth and therapeutic invention strategies against lymphoma. Genetically altered mice including both transgenic and knockout mice offer important models to test the role of specific viral and host genes in the development of HTLV-1-associated lymphoma. Novel approaches in genetic manipulation of both HTLV-1 and animal models are available to address the complex questions that remain about viral-mediated mechanisms of cell transformation and disease. Current progress in the understanding of the molecular events of HTLV-1 infection and transformation suggests that answers to these questions are approachable using animal models of HTLV-1-associated lymphoma Oncogene (2005) 24, 6005-6015.

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Section: Non-human Primate Modelsmentioning

confidence: 99%

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

2005

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“…Phylogenetic analyses indicate that STLVs have been introduced into humans from simians several times over recent millennia [62]. STLV infections of non-human primates are generally asymptomatic but have been associated with anecdotal reports of leukaemia or lymphoma mostly in captive individuals of several primate species: African green monkeys, baboons, macaques and gorillas [63][64][65][66]. These associations suggest that oncogenicity may occur in simian hosts but may be less apparent due to host death and insufficient study.…”

Section: Infectious Cancers In Vertebrates (A) Historical Trendmentioning

confidence: 99%

Infection and cancer in multicellular organisms

Ewald

2015

Phil. Trans. R. Soc. B

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Evolutionary considerations suggest that oncogenic infections should be pervasive among animal species. Infection-associated cancers are well documented in humans and domestic animals, less commonly reported in undomesticated captive animals, and rarely documented in nature. In this paper, we review the literature associating infectious agents with cancer to evaluate the reasons for this pattern. Non-malignant infectious neoplasms occur pervasively in multicellular life, but oncogenic progression to malignancy is often uncertain. Evidence from humans and domestic animals shows that non-malignant infectious neoplasms can develop into cancer, although generally with low frequency. Malignant neoplasms could be difficult to find in nature because of a low frequency of oncogenic transformation, short survival after malignancy and reduced survival prior to malignancy. Moreover, the evaluation of malignancy can be ambiguous in nature, because criteria for malignancy may be difficult to apply consistently across species. The information available in the literature therefore does not allow for a definitive assessment of the pervasiveness of infectious cancers in nature, but the presence of infectious neoplasias and knowledge about the progression of benign neoplasias to cancer is consistent with a widespread but largely undetected occurrence.

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“…In addition to the retrovirus-induced immunodeficiency, the development of lymphomas is thought to be associated with coinfection with one of two types of gammaherpesviruses, namely simian lymphocryptoviruses (LCVs), the simian equivalent of EBV (Blaschke et al, 2001;Bruce et al, 2012;Carville and Mansfield, 2008;Habis et al, 2000;Kahnt et al, 2002;Li et al, 1993;Mätz-Rensing et al, 1999;Pingel et al, 1997), and rhadinoviruses (Bruce et al, 2012;Orzechowska et al, 2008). In contrast to the aforementioned retroviruses, simian T-cell lymphotropic virus (STLV) associated lymphomagenesis in nonhuman primates does not seem to require a herpesviral co-infection (Allan et al, 2001;Homma et al, 1984;Hubbard et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Intravascular T-cell lymphoma in a patas monkey (Erythrocebus patas)

et al. 2017

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Abstract.A 9-year-old female captive patas monkey (Erythrocebus patas) presented with poor general condition, inability to stand, petechiae, anaemia, thrombocytopenia, and leukocytosis. Due to poor response to treatment, the animal was euthanized 16 days later. Postmortem examination revealed hemorrhages in several organs and bilateral cerebral infarctions. Histologically, prominent accumulations of large neoplastic lymphocytes in cerebral and meningeal blood vessels were demonstrated within the lesions and in other organs (e.g., bone marrow, ovary, intestine). Immunohistochemically, neoplastic cells expressed CD3 and Ki-67. PCR revealed a lymphocryptovirus (LCV) infection, while Epstein-Barr nuclear antigen 2 (EBNA2) could not be demonstrated within neoplastic cells by means of immunohistochemistry. Based on the pathological findings, an intravascular lymphoma (IVL) of T-cell origin was diagnosed. To the authors' knowledge, this is the first report on this rare entity in a nonhuman primate.

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Lymphoma in Macaques: Association with Virus of Human T Lymphotrophic Family

Cited by 130 publications

References 26 publications

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Animal models for human T-lymphotropic virus type 1 (HTLV-1) infection and transformation

Infection and cancer in multicellular organisms

Intravascular T-cell lymphoma in a patas monkey (Erythrocebus patas)

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