Lymphoma of the cervix: A diagnostic pitfall on cervicovaginal smear

Çallı, Aylin Örgen; Rezanko, Türkan; Yiğit, Seyran; Payzın, Bahriye

doi:10.4103/0970-9371.101184

Cited by 11 publications

(13 citation statements)

References 6 publications

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“…Malignant lymphoma of the uterine cervix is very rare. The overall incidence of malignant lymphomas of the cervix is less than 1% among all cervical malignancies ( Calli et al, 2012 ). Usually, malignant lymphoma produces a bulky and hard tumor in the uterine cervix and the tumor grows rapidly.…”

Section: Discussionmentioning

confidence: 99%

Two cases of spindle cell variant diffuse large B-cell lymphoma of the uterine cervix

Murata

Ohta

Kitamura

et al. 2020

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 99%

Two cases of spindle cell variant diffuse large B-cell lymphoma of the uterine cervix

Murata

Ohta

Kitamura

et al. 2020

Gynecologic Oncology Reports

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“…Primary lymphoma of the uterine cervix (PLUCX) and corpus accounts for only 0.5% of extra-nodal malignant lymphomas, and among all cervical malignancies, the overall incidence of PLUCX is less than 1% [1]. Lymphomas of the female genital tract may be a primary manifestation of this area or may occur as genital recurrences or metastases that were initially diagnosed elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Primary diffuse large B-cell lymphoma of uterine cervix diagnosed by cytology and concurrent cervical biopsy: a case report and literatures reviews since 1980

Kim¹,

Ahn²,

Hong³

2021

European Journal of Gynaecological Oncology

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Malignant lymphoma of the uterine cervix is rare with non-specific clinical presentation and is di ficult to diagnose via cervical cytology. The current study presents a case of primary malignant lymphoma of the uterine cervix diagnosed via initial conventional smear cytology and subsequent cervical biopsy. We present a case of an 81-yearold woman with vaginal bleeding post-urination. The conventional smear cytology showed scattered large atypical lymphoid cells with necrotic debris. The concurrently biopsied specimen revealed large monotonous atypical lymphoid cells, which were immunoreactive for CD20 with high Ki-67 proliferative index, consistent with di fuse large B-cell lymphoma (DLBCL). Due to the transfer of the patient to another hospital, any other examinations associated with staging were not performed. Although rare, the likelihood of malignant lymphoma should be considered while screening for cervical cancer through cytology using Pap smear or conventional smear. Cytological screening may be useful for the early diagnosis of malignant lymphoma of the uterine cervix. Immediate and appropriate treatment can be initiated with a quick and accurate diagnosis. Herein, we report a case of primary uterine cervical DLBCL and review the literatures comprising 106 cases studies with 255 cases of primary cervical lymphoma reported since 1980 including clinical and histological characteristics through MEDLINE database.

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“…Malignant lymphoma of the uterine cervix and corpus is relatively rare and accounts for only 0.5% of extranodal lymphomas. The overall incidence of malignant lymphomas of the uterine cervix is less than 1% among all cervical malignancies (1), and only a few cases have been reported to date (2)(3)(4). It is difficult to diagnose malignant lymphomas of the uterine cervix by cervical cytology because lymphomas at this site are rare and can be misdiagnosed as other clinical conditions such as chronic cervicitis and epithelial malignancies (e.g., small cell carcinoma and poorly differentiated adenocarcinoma) (1).…”

Section: Introductionmentioning

confidence: 99%

Malignant lymphoma of the uterine cervix presumptively diagnosed by Pap smear: A case report

et al. 2018

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Malignant lymphoma of the uterine cervix is exceedingly rare and is difficult to diagnose by cervical cytology. The current study presents a case of malignant lymphoma of the uterine cervix that was presumptively diagnosed by cervical cancer screening in which the patient had no clinical symptoms. The anterior lip of the uterine cervix was occupied by a macroscopic hemorrhagic tumor. The obtained tumor cells exhibited typical cytological features of malignant lymphoma and were positive for CD20. The final diagnosis was diffuse large B cell lymphoma of the uterine cervix, stage IIEA (Ann Arbor classification). The patient received 6 courses of R-CHOP chemotherapy and achieved complete remission. Despite its rarity, the possibility of malignant lymphoma should be considered while screening for cervical cancers using Pap smears. The Pap test screening may be useful for the early diagnosis of malignant lymphoma of the uterine cervix in certain cases. By reaching a rapid and accurate diagnosis, immediate treatment may be initiated and surgery may be avoided.

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Lymphoma of the cervix: A diagnostic pitfall on cervicovaginal smear

Cited by 11 publications

References 6 publications

Two cases of spindle cell variant diffuse large B-cell lymphoma of the uterine cervix

Two cases of spindle cell variant diffuse large B-cell lymphoma of the uterine cervix

Primary diffuse large B-cell lymphoma of uterine cervix diagnosed by cytology and concurrent cervical biopsy: a case report and literatures reviews since 1980

Malignant lymphoma of the uterine cervix presumptively diagnosed by Pap smear: A case report

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