Lymphoma of the Cervix: Case Report and Review of the Literature

Hilal, Ziad; Hartmann, Fritz; Doğan, Aşkın; Çetin, Cem; Krentel, Harald; Schiermeier, Sven; Schultheis, Beate; Tempfer, Clemens B.

doi:10.21873/anticanres.11059

Cited by 24 publications

(25 citation statements)

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“…Prognosis of female genital lymphomas in general and LUCx in particular has been described to be poorer than nodal lymphomas. 5,37 However, when diagnosed at early stage the prognosis is excellent. 14,38 The importance of diagnosing the disease at an early stage is…”

Section: Discussionmentioning

confidence: 99%

Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review

et al. 2020

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Background: Primary lymphomas involving the female genital tract are rare, and those arising from cervix are extremely uncommon. They are often misdiagnosed because of their rarity. Methods and cases: The treatment and clinical outcomes of the four cases treated at our institution were compared with the previously published studies. Written informed consent was taken. We highlight four cases of primary diffuse large B-cell lymphoma of cervix treated at our institution with immunochemotherapy and radiotherapy. The mean age was 50 years (range, 39-62 years). Three patients had stage I disease while one had stage II disease. All the patients were in complete remission following treatment with immunochemotherapy and radiation therapy. The average disease free survival was 20 months (range, 8-43 months). None of the patients had any local or systemic relapse. Conclusion: These cases highlight the physicians to be aware of this entity as their management, natural history and prognosis is completely different from squamous carcinomas of the cervix. Surgery should not be attempted in these patients. Immunochemotherapy and radiotherapy results in favorable clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review

et al. 2020

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“…1 Female genital tract lymphomas are rare, accounting for 1.5% of extranodal non-Hodgkin's lymphomas and < 0.5% of gynaecological cancers. [2][3][4][5][6]8 In a series of 186 cases, of which 97 were primary isolated lymphomas, adnexal tropism accounted for 47% compared with 9% cervical involvement. Primary or secondary female genital tract lymphomas may occur in all internal and external female genital organs, and the cervix is one of the less commonly affected loci.…”

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confidence: 99%

“…Primary or secondary female genital tract lymphomas may occur in all internal and external female genital organs, and the cervix is one of the less commonly affected loci. 3,6 However, early diagnosis and appropriate treatment provide significant upsurge in survival rates. 5 Prognosis of female genital lymphomas has been described to be poorer than that of the more common nodal lymphomas.…”

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confidence: 99%

“…[2][3][4][5][6]8 In a series of 186 cases, of which 97 were primary isolated lymphomas, adnexal tropism accounted for 47% compared with 9% cervical involvement. 2-4,6,7,11 Hilal et al 6 described > 60% of patients being diagnosed in early, localised stages, conferring an overall 5-year survival rate of approximately 80%. 3,6 However, early diagnosis and appropriate treatment provide significant upsurge in survival rates.…”

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confidence: 99%

“…5 Prognosis of female genital lymphomas has been described to be poorer than that of the more common nodal lymphomas. 3,6 However, early diagnosis and appropriate treatment provide significant upsurge in survival rates. [2][3][4]6,7,11 Hilal et al 6 described > 60% of patients being diagnosed in early, localised stages, conferring an overall 5-year survival rate of approximately 80%.…”

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confidence: 99%

See 2 more Smart Citations

Advanced Doppler imaging and trucut biopsy of a late‐stage cervical lymphoma

Heremans

Froyman

Beckers

et al. 2019

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Cancer of the vagina

Adams

Cuello

2018

Intl J Gynecology & Obste

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Diagnosis of a primary vaginal cancer is rare because most of these lesions will be metastatic from another primary site. Although cancer of the vagina is more common in postmenopausal women, an increase in young women being diagnosed with primary vaginal cancer has been reported, especially in countries with a high HIV prevalence. This will be associated with persistence of high‐risk HPV infection. The emphasis should be on primary prevention with prophylactic HPV vaccination. Once there is a suspicion of a primary vaginal cancer, this should be confirmed histologically with biopsy. Staging has been done clinically, similar to cervical cancer; however, there is a role for imaging in assisting with staging as this is often a difficult assessment. Treatment should be individualized and depends on stage as well as histologic subtype. It is prudent to refer cases to centers of excellence with experience in dealing with this rare gynecological cancer.

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Lymphoma of the Cervix: Case Report and Review of the Literature

Abstract: LUCX is rare and has distinct clinical and histological features. LUCX is usually treated with local surgical excision followed by radiotherapy or chemotherapy.

Cited by 24 publications

References 4 publications

Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review

Primary diffuse large B cell lymphoma of Uterine Cervix: Treatment outcomes of a rare entity with literature review

Advanced Doppler imaging and trucut biopsy of a late‐stage cervical lymphoma

Cancer of the vagina

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