Lymphomas of the head and neck in dermatological practice

Sokołowska‐Wojdyło, Małgorzata; Sikorska, Monika; Florek, Aleksandra G.; Drogoszewska, Barbara; Kowalczyk, Anna; Starzyńska, Anna; Szczerkowska-Dobosz, Aneta; Barańska‐Rybak, Wioletta; Włodarkiewicz, Adam

doi:10.5114/pdia.2012.30473

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…The most common site of an OSCC is the floor of the mouth or the lateral/ventral tongue surface [8,9], but it also touches the lips, gums, cheeks, and hard palate. Other cancers of the oral region include lymphomas (3.5%) [10], sarcomas, small salivary glands, odontogenic tumours, and malignant melanomas [11].…”

Section: Introductionmentioning

confidence: 99%

The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach

Smędra

Berent

2023

Biomolecules

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In our recent article (Smędra et al.: Oral form of auto-brewery syndrome. J Forensic Leg Med. 2022; 87: 102333), we showed that alcohol production can occur in the oral cavity (oral auto-brewery syndrome) due to a disruption in the microbiota (dysbiosis). An intermediate step on the path leading to the formation of alcohol is acetaldehyde. Typically, acetic aldehyde is transformed into acetate particles inside the human body via acetaldehyde dehydrogenase. Unfortunately, acetaldehyde dehydrogenase activity is low in the oral cavity, and acetaldehyde remains there for a long time. Since acetaldehyde is a recognised risk factor for squamous cell carcinoma arising from the oral cavity, we decided to analyse the relationship linking the oral microbiome, alcohol, and oral cancer using the narrative review method, based on browsing articles in the PubMed database. In conclusion, enough evidence supports the speculation that oral alcohol metabolism must be assessed as an independent carcinogenic risk. We also hypothesise that dysbiosis and the production of acetaldehyde from non-alcoholic food and drinks should be treated as a new factor for the development of cancer.

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Section: Introductionmentioning

confidence: 99%

The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach

Smędra

Berent

2023

Biomolecules

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“…Primary cutaneous lymphoma (PCL) is a rare group of non-Hodgkin lymphomas that primarily arise in the skin and typically do not involve lymph nodes or other organs at the time of diagnosis [2]. Among its various subtypes, cutaneous B-cell lymphoma is the most commonly encountered, representing about 20-25% of all primary cutaneous lymphomas [2][3][4]. The 2018 update from the World Health Organization-European Organization for Research and Treatment of Cancer identifies three main subtypes of primary cutaneous B-cell lymphoma (pCBCL): primary cutaneous marginal zone lymphoma (PCMZL), primary cutaneous follicle center lymphoma (PCFCL), and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT).…”

Section: Introductionmentioning

confidence: 99%

Diffuse Large B-Cell lymphoma Misdiagnosed as a Hematoma: Case Report

Lee,

Yun

2023

Medicina

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Background: Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin’s lymphoma, often presents diagnostic challenges due to its diverse clinical presentation. We present a case of DLBCL that was initially misdiagnosed as a hematoma, highlighting the importance of considering malignancy when faced with unresponsive soft tissue swelling. Methods: A 76-year-old man presented to the emergency department with right periorbital swelling and ecchymosis following a traumatic injury. Despite ongoing anticoagulant therapy (warfarin) for atrial fibrillation, the symptoms persisted. A CT scan of the facial bones revealed a large, irregular, homogeneous mass. Initially, the clinical history and radiologic findings suggested an extraconal hematoma. As a result, an incision and drainage procedure was performed, and the old blood was evacuated. However, the patient’s symptoms continued to worsen. A follow-up CT scan showed enlargement of the lesion, prompting a surgical excisional biopsy. Results: Pathologic examination of the excised mass revealed a diffuse infiltrate of lymphocytes surrounding the tissue, confirming the diagnosis of diffuse large B-cell lymphoma (DLBCL). The patient was subsequently referred to hematology for further management. Conclusions: Although rare, DLBCL is associated with a challenging prognosis. This case highlights the diagnostic complexities that can arise, particularly when factors such as prior injury and anticoagulant therapy confound the clinical picture. The initial misclassification of the condition as a hematoma led to a delay in diagnosis and the subsequent initiation of treatment. Therefore, it is imperative to remain vigilant and consider malignancy as a potential underlying cause of unresponsive soft tissue swelling. Timely recognition and accurate diagnosis are paramount to improving patient outcomes in DLBCL, an aggressive lymphoma with a diverse clinical presentation.

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“…Cutaneous B-cell lymphomas comprise 20–25% of all primary cutaneous lymphomas [ 4 – 6 ]. Primary cutaneous diffuse large B-cell lymphomas (PCDLBCL) are composed of large B cells (centroblasts and immunoblasts).…”

Section: Introductionmentioning

confidence: 99%

A case of diffuse large B-cell lymphoma misdiagnosed as an erysipelas of the face

Teresiak-Mikołajczak¹,

Szymańska²,

Czarnecka‐Operacz³

2013

pdia

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We report a case of a woman with diffuse large B-cell lymphoma (DLBCL). Primary cutaneous lymphomas (PCLs) represent distinct clinical and histopathologic subtypes of extranodal T- and B-cell lymphomas. Cutaneous B-cell lymphomas comprise 20–25% of all primary cutaneous lymphomas. The patient presented an erythematous tumour mass of the left nasolabial fold, nose and left cheek as well as disseminated infiltrative plagues on the trunk, arms and left lower leg. Skin biopsy revealed a diffuse infiltrate of lymphocytes around hair follicles and blood vessels within dermis and subcutaneous tissue. An immunohistochemistry showed a diffuse infiltrate of large non-cleaved B-cells, with a high proportion of centroblast-like cells within dermis. Tumor cells expressed CD20, bcl-2 protein and did not express CD10. The patient was misdiagnosed as the erysipelas of the face and unsuccessfully treated with long-term antibiotic therapy by a laryngologist and a dermatologist. The correct diagnosis was delayed and established after 6 months’ history of DLBCL lesions. Therefore, we would like to strongly stress the importance of considering diagnosis of cutaneous lymphomas in chronic skin lesions non-responsive to adequate therapies.

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Lymphomas of the head and neck in dermatological practice

Abstract: A Ad dd dr re es ss s f fo or r c co or rr re es sp po on nd de en nc ce e: :

Cited by 4 publications

References 44 publications

The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach

The Influence of the Oral Microbiome on Oral Cancer: A Literature Review and a New Approach

Diffuse Large B-Cell lymphoma Misdiagnosed as a Hematoma: Case Report

A case of diffuse large B-cell lymphoma misdiagnosed as an erysipelas of the face

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