Lymphomatoid Papulosis Associated with Cutaneous T-Cell Signet Ring Lymphoma

Abstract

The authors describe a new case of cutaneous T-cell lymphoma of signet ring cell type with CD-30 (Ki-t) expression. The patient was a 52-year-old woman with a 20-year history of recurrent papulonodular lesions characteristic of lymphomatoid papulosis (LP). Subsequent to developing the signet ring cell lymphoma (SRL) the patient's cutaneous lesions did not resolve as previously, and a skin biopsy showed a diffuse proliferation of atypical lymphoid cells with cytoplasmic vacuoles. SRL was first reported in 1985 by Weiss, and a literature search found only six further reports since then. Vaillant suggests that the peculiar morphology is retated to the special indolent course of this condition and that the cutaneous form should be considered a distinct entity. This is the first report of a patient with LP who subsequently developed a cutaneouis T-cell signet ring lymphoma with CD-30 antigen expression. The case could be an example of a so-called borderline lymphoma.

CD30+ Primary Cutaneous Post-Transplant Lymphoproliferative Disorder with Signet-Ring Cell Features

“… 4 However, there are reported cases of post-transplant CD30+ anaplastic large cell lymphoma (ALCL) associated with EBV. 5 Regardless, as in the case of our patient, the pathogenesis of CD30+ T-cell lymphoma can occur independent of EBV. CD30+ cutaneous lymphoproliferative disorders encompass the second most common form of cutaneous lymphomas according to the World Health Organization and European Organization for Research and Treatment of Cancer Classification (WHO-EORTC).…”

Ileostomy-Associated Chronic Papillomatous Dermatitis Showing Nevus Sebaceous–Like Hyperplasia, HPV 16 Infection, and Lymphedema

“…6 For instance, the neutrophil-rich (pyogenic) variant has emerged as a subtype of primary cutaneous ALCL, which may have different clinical parameters than the conventional type. 6,[8][9][10][11][12] We believe this case to represent perhaps the first case of a primary cutaneous CD30+ T-cell PTLD with signet ring cells. 6,[8][9][10][11][12] We believe this case to represent perhaps the first case of a primary cutaneous CD30+ T-cell PTLD with signet ring cells.…”

“…8,9 Grogan et al 10 demonstrated the cells had a vacuolar staining in "pools" for several T-cell antigens and, along with the ultrastructural evidence, concluded that aberrant membrane recycling may be implicated in the formation of the vacuoles. Negative staining with mucicarmine, 11 alcian blue, and oil red-O 9 argues against the material being mucin or fat.…”