Lymphomatosis cerebri as a cause of white matter dementia

Rollins, Karen E.; Kleinschmidt‐DeMasters, Bette K.; Corboy, John R.; Damek, Denise; Filley, Christopher M.

doi:10.1016/j.humpath.2005.01.014

Cited by 80 publications

(78 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 Radiographically, there is diffuse white matter involvement without enhancement. Histologically, the widespread, diffuse infiltration by lymphocytes with some perivascular cuffing can be mistaken for viral encephalitis.…”

Section: Lymphomatosis Cerebrimentioning

confidence: 99%

Pathology of primary central nervous system lymphoma

Commins¹

2006

FOC

View full text Add to dashboard Cite

✓ The understanding of primary central nervous system lymphoma (PCNSL) has lagged behind that of the much more common systemic, nodal lymphomas. Reasons for this include the relative rarity of PCNSL and the fact that these lesions differ in some ways from their histologically similar systemic counterparts. The purpose of this paper is twofold: first, the author provides concise descriptions of the pathological features of both common and uncommon types of PCNSL while discussing issues such as the confusion surrounding histological classification of PCNSLs, problems related to intraoperative diagnosis, and the appropriate diagnostic work up. Second, the author discusses a small number of molecular studies to demonstrate the great promise they offer. Such studies have already clarified some issues, including the category of lymphocyte from which the majority of PCNSLs are derived. Hopefully in the future these studies will help guide treatment decisions.

show abstract

Section: Lymphomatosis Cerebrimentioning

confidence: 99%

Pathology of primary central nervous system lymphoma

Commins¹

2006

FOC

View full text Add to dashboard Cite

show abstract

“…Lymphomatosis cerebri (LC), an atypical rare form of PCNSL, presents as a diffuse infiltration without the formation of a mass lesion (2). Its appearance on brain MRI is characterized by diffuse leukoencephalopathy, making LC difficult to distinguish from white matter disorders such as infection, inflammation and vascular and toxic diseases (3)(4)(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

et al. 2015

View full text Add to dashboard Cite

A 71-year-old immunocompetent man developed cognitive decline and gait disturbance. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without a mass lesion. An analysis of the cerebrospinal fluid (CSF) showed elevated levels of interleukin (IL)-10. The condition of the patient progressively deteriorated, and intravenous high-dose steroids proved ineffective. Detection of nondestructive, diffusely infiltrating, large B-cell lymphoma in biopsy and autopsy specimens led to a diagnosis of lymphomatosis cerebri (LC). On serial MRI, the basal ganglia and white matter lesions increased in parallel with the levels of IL-10. These findings suggest that the IL-10 level in the CSF may represent a potentially useful biomarker for the early diagnosis and monitoring of the disease progression in LC.

show abstract

“…Because the differential diagnosis of leukoencephalopathy includes various neurological etiologies, it is usually difficult to diagnose PCNSL in the early stage especially when PCNSL shows diffuse infiltrative leukoencephalopathy without mass lesion formation (1). In the present case, the correct diagnosis was confirmed a year after the onset of symptoms.…”

Section: Discussionmentioning

confidence: 50%

“…Although tumors rarely manifest as part of the clinical course of leukoencephalopathy, it is usually difficult to diagnose correctly when they do not form solitary lesions (1). Primary central nervous system lymphoma (PCNSL) is a rare central nervous system tumor, accounting for approximately 4% of all primary central nervous system tumors (2).…”

Section: Introductionmentioning

confidence: 99%

A Case of Primary Central Nervous System Lymphoma Presenting Diffuse Infiltrative Luekoencephalopathy

et al. 2012

View full text Add to dashboard Cite

A 58-year-old immunocompetent man gradually developed loss of appetite, cognitive decline, gait disturbances, and personality changes over 4 months. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without mass formation on admission. His condition progressively deteriorated, and we treated him with intravenous high-dose steroids. His symptoms improved rapidly, but exacerbated when therapy was withdrawn. A brain biopsy was performed, and the diagnosis of primary central nervous system lymphoma (PCNSL) was confirmed. He was successfully treated with high-dose methotrexate therapy. Although it is difficult to diagnose PCNSL without mass formation in the early stages, steroid responsiveness is important and brain biopsy is essential for the correct diagnosis of PCNSL.

show abstract

Lymphomatosis cerebri as a cause of white matter dementia

Cited by 80 publications

References 37 publications

Pathology of primary central nervous system lymphoma

Pathology of primary central nervous system lymphoma

Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

A Case of Primary Central Nervous System Lymphoma Presenting Diffuse Infiltrative Luekoencephalopathy

Contact Info

Product

Resources

About