Lymphopoiesis in the Thymus and Other Tissues: Functional Implications

Everett, N. B.; Tyler, Ruth

doi:10.1016/s0074-7696(08)61836-7

Cited by 125 publications

(41 citation statements)

References 84 publications

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“…The concept of functional heterogeneity of the peripheral lymphocyte pool is supported by a large body of experimental evidence which indicates that the peripheral blood lymphocyte pool of rodents consists of at least two distinct cell populations (21,22 (23)(24)(25)(26)(27).…”

Section: Resultsmentioning

confidence: 99%

Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man

Weiden¹,

Blaese²,

Strober³

et al. 1972

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man

Weiden¹,

Blaese²,

Strober³

et al. 1972

J. Clin. Invest.

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“…On the other hand, lymph node lymphocytes from "desensitized" animals were readily induced by antigen to incorporate thymidine and behaved like cells from nondesensitized animals. Retention of antigen-reactive lymphocytes in lymph nodes and depletion of antigen-reactive peripheral lymphocytes at inflammatory exudates or skin may explain the shortlived nature of the desensitization phenomenon and further demonstrates the compartmentalization of lymphocytes (9)(10)(11)(12).…”

mentioning

confidence: 95%

The Compartmentalization of Antigen-Reactive Lymphocytes in Desensitized Guinea Pigs

Schlossman

Levin

Rocklin

et al. 1971

The Journal of Experimental Medicine

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A single injection of ϵ,DNP-Lys7–10 can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritoneal exudates of those animals. In contrast, it was intriguing to find that lymph node lymphocytes from such animals responded normally in the antigen-induced thymidine incorporation assay. These studies demonstrate a compartmentalization of antigen-reactive lymphocytes in desensitized animals which may account for the short-lived nature of this phenomenon.

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“…But the issue cannot be resolved by morphological analysis, because the small round cells in exudates ultimately derive from a heterogeneous population of blood-borne lymphocytes. The latter differ with respect to turnover (5), circulating life-span (5,6), and possibly with respect to origin and function.…”

mentioning

confidence: 99%

The Mediator of Cellular Immunity

Koster

McGregor

1971

The Journal of Experimental Medicine

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Mononuclear cells with the structural features of lymphocytes are especially numerous in delayed-type hypersensitivity (DTH) 1 reaction sites, in allografts undergoing rejection, and in the lesions of certain autoimmune diseases (1-4). The origin of these "small round cells" and their possible role in cell-mediated immunity have been the subject of an unduly prolonged debate, based mainly upon morphological evidence. But the issue cannot be resolved by morphological analysis, because the small round cells in exudates ultimately derive from a heterogeneous population of blood-borne lymphocytes. The latter differ with respect to turnover (5), circulating life-span (5, 6), and possibly with respect to origin and function.In an earlier study, using normal nonimmunized rats (7), it was found that a portion of the small mononuclear cells in peritoneal exudates induced by casein derive from newly formed lymphocytes which enter the blood by way of the thoracic duct. Small lymphocytes of the kind which have a slow turnover rate and a potentially long circulating life-span were excluded, although cells of this type comprise approximately 90% of those normally present in central 1)ralph (8). Results of the present investigation reaffirm and extend these observations by showing that newly formed lymphocytes from rats infected with Listeria monocytogenes can move in substantial numbers into exudates induced by casein bacteria. The disposition of these lymphocytes assumes impgrtance when one considers that they include the specific mediators of cellular resistance to infection (6). The ability of specifically committed lymphocytes to localize in inflammatory foci provides a plausible explanation for the protective property of

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Lymphopoiesis in the Thymus and Other Tissues: Functional Implications

Cited by 125 publications

References 84 publications

Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man

Impaired lymphocyte transformation in intestinal lymphangiectasia: evidence for at least two functionally distinct lymphocyte populations in man

The Compartmentalization of Antigen-Reactive Lymphocytes in Desensitized Guinea Pigs

The Mediator of Cellular Immunity

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