2013
DOI: 10.5858/arpa.2012-0202-ra
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Lymphoproliferative Neoplasms of the Lung: A Review

Abstract: Context.-Diagnosis and classification of lymphomas are based on the morphologic, immunologic, and genetic features that the lesional cells share with their normal B and T lymphocyte counterparts. Primary pulmonary lymphomas account for 0.3% of primary lung neoplasms and less than 0.5% of all lymphomas.Objective.-To describe and summarize the clinical and histopathologic features of the primary pulmonary lymphoma and secondary involvement of the lung by lymphoma.Data Sources.-Peer-reviewed published literature … Show more

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Cited by 62 publications
(90 citation statements)
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“…Immunohistochemistry provides the definitive diagnosis in histopathologically indistinct cases 25. PPHL tumour cells are positive for CD15, CD30, Pax5 and rarely CD20, and negative for T-cell markers 26 27. The most considered diagnoses in the current case were tuberculosis, congenital adenoid cystic malformation on the basis of radiology and Langerhans histiocytosis on the basis of the initial histopathology.…”
Section: Discussionmentioning
confidence: 72%
See 1 more Smart Citation
“…Immunohistochemistry provides the definitive diagnosis in histopathologically indistinct cases 25. PPHL tumour cells are positive for CD15, CD30, Pax5 and rarely CD20, and negative for T-cell markers 26 27. The most considered diagnoses in the current case were tuberculosis, congenital adenoid cystic malformation on the basis of radiology and Langerhans histiocytosis on the basis of the initial histopathology.…”
Section: Discussionmentioning
confidence: 72%
“…It has been generally accepted that, for diffuse and bilateral lesions, the combination of multiple-agent chemotherapy and radiotherapy is required 12 17 34. Recent authors have recommended chemotherapy over radiotherapy due to the risk of radiation pneumonitis 27 35Learning points

Primary pulmonary Hodgkin's lymphoma is a rare disease and is distinct from Hodgkin's lymphoma affecting the lungs secondarily.

The clinical presentation and the radiological and histological appearances are non-specific.

Immunohistochemical evaluation of open lung specimens is in most cases required to make the diagnosis.

The challenges of the diagnostic process can delay potentially curative therapy.

…”
Section: Discussionmentioning
confidence: 99%
“…No vessel necrosis is observed. This pattern is described as an “angiocentric process,” although the blood vessels are secondarily engulfed by the spreading infiltrate, which randomly affects lung parenchyma 2 , 19. The possible role of EBV in the pathogenesis of LYG was raised in 1990 by Katzenstein and Peiper,21 and subsequently confirmed in several studies.…”
Section: Discussionmentioning
confidence: 97%
“…Eventually, hemoptysis may be present. Clinical features may also reflect a multiorgan systemic disease, because, in addition to pulmonary involvement, the skin, brain, kidneys, and liver may be affected independently or concurrently in the late course of illness 2 , 19…”
Section: Discussionmentioning
confidence: 99%
“…Various modifications can be observed in the parenchyma adjacent to the neoplastic nodules of Hodgkin lymphoma, including focal organising pneumonia, endoalveolar accumulations of foamy macrophages and interstitial lymphoid infiltration. Differential diagnoses for classic Hodgkin lymphoma include solitary fibrous tumour with extensive inflammation and inflammatory myofibroblastic tumour [36].…”
Section: Primary Pulmonary Lymphomasmentioning
confidence: 99%