Lyotropic phase behaviour of n-octyl-1-O-?-D-glucopyranoside and its thio derivative n-octyl-1-S-?-D-glucopyranoside

Sakya, P.; Seddon, John M.; Templer, Richard H.

doi:10.1051/jp2:1994202

Cited by 56 publications

(81 citation statements)

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“…The large birefringence domain is the specific nature of H phase ( Figure S3, Supporting Information). 6,8,10) The correlation between the ordering size of the H phase and the lack of a peak for the I solution were supported by the XRD results. A higher contrast in Fig.…”

Section: Resultsmentioning

confidence: 63%

“…The variation of d size of lamellar structure depending on the hydration level have been reported at room temperature. 6) In Fig. 3b, the decrease of starting temperature of main melting of eutectic was observed in the presence of β-OGlu.…”

Section: Resultsmentioning

confidence: 83%

“…Because the aggregation sizes of the β-OGlu assembly (3.50 nm or 2.85-3.00 nm) were attributable to the d values of the (100) plane of the H-phase and the (001) plane of Lα-phase, 6) we assumed that each phase and coexisted phase must exist in the temperature range between ca. −26 and −23°C and in that below −26°C.…”

Section: Resultsmentioning

confidence: 99%

“…9) Under ambient atmosphere, β-OGlu forms an isotropic micelle solution (I) and lyotropic liquid crystalline phases composed of hexagonal (H), cubic (Q), and lamellar (Lα) phases in a pure water system, depending on the hydration circumstance of its sugar moiety. [6][7][8] In our previous study, 10) lyotropic phase transitions of liquid crystalline phases were observed due to the change of the concentration of β-OGlu during the ice freezing and thawing processes. Specific ice crystal growth from spherical to a hexagonal symmetry was recognized in the micelle solution.…”

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confidence: 95%

“…Also, it is known to form lyotropic liquid crystalline phases. [6][7][8] The materials that changes the aggregation structure in response to the hydration level of its hydrophilic components are defined as lyotropic liquid crystalline materials. 9) Under ambient atmosphere, β-OGlu forms an isotropic micelle solution (I) and lyotropic liquid crystalline phases composed of hexagonal (H), cubic (Q), and lamellar (Lα) phases in a pure water system, depending on the hydration circumstance of its sugar moiety.…”

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confidence: 99%

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Lyotropic Behavior of a Mono-tailed Glycolipid Assembly during Solidification and Melting of Electrolyte/Ice Eutectic Systems

Ogawa

Asakura

Osanai

2014

CHEMICAL & PHARMACEUTICAL BULLETIN

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The properties of low molecular weight glycolipids at subzero temperatures have been paid much attention due to their great potential for applications in cryopreservation. In this study, the ability of glycolipids to maintain their lyotropic properties was investigated by analyzing the aggregation behavior of octyl-β-Dglucoside (β-OGlu) during solidification and melting of electrolyte/ice eutectic mixtures using a simultaneous X-ray diffraction-differential scanning calorimetry measurement and cryomicroscopic observation. During the freezing process, eutectic formation increased the concentration of the β-OGlu micelle solution in the unfrozen phase, leading to ordering of the molecular assembly. The molecular assembly exhibited a reversible phase transformation between liquid crystalline phases (e.g., lamellar (Lα) and hexagonal (H) phases) and an isotropic micelle solution (I), depending on the degree of eutectic formation, which was regulated by temperature. Because the coexistence of electrolyte/ice eutectic often induces the dehydration of lipids, the persistence of lyotropic properties under such arid conditions demonstrates an attractive performance of glycolipids for use in low temperature applications, such as the cryopreservation of poorly water-soluble drugs or proteins.

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Section: Resultsmentioning

confidence: 63%

Section: Resultsmentioning

confidence: 83%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 95%

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confidence: 99%

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