Lysine harvesting is an antioxidant strategy and triggers underground polyamine metabolism

Abstract

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Mitochondrial respiration is required to provide amino acids during fermentative proliferation of fission yeast

“…These catabolic processes yield energy in the form of ATP, reducing equivalents in the form of NAD(P)H and FADH, as well as a series of intermediates required for anabolic (biosynthetic) metabolism. The flux distributions between all three pathways are dynamically adjusted by the cell to achieve an optimal level of growth and resilience given a specific lifestyle, stress condition, or ecological niche [1][2][3][4][5]. These metabolic adaptations are of fundamental importance for cellular physiology as they determine their tolerance for changing conditions and stress [6].…”

The future of groundwater in sub-Saharan Africa

“…These results demonstrate a limitation of regional-scale assessments of the effects of climate change on groundwater resources, such as those published by the Intergovernmental Panel on Climate Change 1 . The large spatial scale of the climate-model predictions used in such assessments precludes a consideration of the variability and intensity of precipitation at the smaller scales that control aquifer replenishment in some environments.…”

“…The large spatial scale of the climate-model predictions used in such assessments precludes a consideration of the variability and intensity of precipitation at the smaller scales that control aquifer replenishment in some environments. Cuthbert and colleagues' findings thus call into question previous conclusions, such as that "climate change is projected to reduce renewable surface water and groundwater resources significantly in most dry subtropical regions" 1 .…”

“…T he population of sub-Saharan Africa is currently about 1 billion, and is predicted to double by 2050 (go.nature. com/2zj9kca), whereas the region's climate is predicted to become drier during the same period 1 . Clearly, the demand for fresh water will increase.…”

Engineering of membrane phospholipid component enhances salt stress tolerance in Saccharomyces cerevisiae

“…The efficiency of microbial cell factories depends on their synthetic ability, growth performance, and stress tolerance. To increase the tolerance of industrial strains to environmental stress (Chakraborty, Winardhi, Morgan, Yan, & Kenney, ; Olin‐Sandoval et al, ), a series of strategies have been developed. These include global transcription machinery engineering (Alper, Moxley, Nevoigt, Fink, & Stephanopoulos, ), adaptive laboratory evolution (Walker, Ryu, & Trinh, ), mutagenesis breeding (Cui et al, ), transporter engineering (Kell, Swainston, Pir, & Oliver, ), and membrane engineering (Tan et al, ).…”