Lysophosphatidic Acid as a Novel Lipid Mediator

Moolenaar, Wouter H.; Jalink, Kees; Eichholtz, Thomas; Hordijk, Peter L.; Bend, Rob van der; Blitterswijk, Wim J. van; Corven, Emile van

doi:10.1016/s0070-2161(08)60991-0

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…In this regard LPA may be particularly important. There is evidence that LPA is an important mediator of oxidant injury in other cell systems [15] and as an inhibitor of a p21rac-GTPase activating protein [16]. p21rac is a member of the ras superfamily of small molecular weight GTP-binding proteins, which has been reported to be required for NADPH oxidase activity [17,18].…”

Section: Resultsmentioning

confidence: 99%

Excess formation of lysophosphatidic acid with age inhibits myristic acid‐induced superoxide anion generation in intact human neutrophils

Ponnappan

Lipschitz

1996

FEBS Letters

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A superoxide anion generation rate upon exposure to myristate of 1.93 + 0.34 nmol/min/106 cells in neutrophils from elderly human donors was significantly less than a value of 3.02 + 0.48 nmol/min/106 neutrophils from young donors. Myristate activation resulted in equal increases of AA in both the young and the old indicating no effect of aging on the PLA2 pathway to response. By contrast, the PLD-induced generation of PA was significantly higher in the old than in the young. In addition, myristate induced a significant age-related enhancement in LPA generation, in the old but not in the young. The mass of LPA generated following activation was 3.5 nmoi/ 2.5 X 107 cellslml in the young while in the old it averaged 7.0 nmol/2.5x 107 cells /ml. The inhibitory effects of LPA may explain the age-related impaired ability to generate superoxide anion following activation by myristate.

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Section: Resultsmentioning

confidence: 99%