2022
DOI: 10.3389/fonc.2022.917471
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Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various Cancers

Abstract: A wide range of microRNAs (miRNAs) are coded for in the human genome and contribute to the regulation of gene expression. MiRNAs are able to degrade mRNAs and/or prevent the RNA transcript from being translated through complementary binding of the miRNA seed region (nucleotide 2-8) to the 3’-untranslated regions of many mRNAs. Although miRNAs are involved in almost all processes of normal human cells, they are also involved in the abnormal functions of cancer cells. MiRNAs can play dual regulatory roles in can… Show more

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Cited by 6 publications
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“…MicroRNAs can inhibit or promote the cancer phenotype by inhibiting the production of oncogenes or tumour suppressors ( 25 , 72 77 ). Typically, tumor-suppressive miRNAs are expressed less than it should while oncogenic miRNAs (oncomiRs) are expressed more than enough in malignancies ( 71 , 78 85 ).…”
Section: Mirna Acts As Oncomir or Tumor Suppressormentioning
confidence: 99%
“…MicroRNAs can inhibit or promote the cancer phenotype by inhibiting the production of oncogenes or tumour suppressors ( 25 , 72 77 ). Typically, tumor-suppressive miRNAs are expressed less than it should while oncogenic miRNAs (oncomiRs) are expressed more than enough in malignancies ( 71 , 78 85 ).…”
Section: Mirna Acts As Oncomir or Tumor Suppressormentioning
confidence: 99%