Lysosomal Storage Disease Caused by<i>Sida carpinifolia</i>Poisoning in Goats

Driemeier, David; Colodel, Edson Moleta; Gimeno, Eduardo Juan; Barros, Severo Sales de

doi:10.1354/vp.37-2-153

Cited by 70 publications

(139 citation statements)

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“…These cellular changes were similar to those reported previously in cattle, 16 goats, 7,13,19 sheep, 33 and ponies 25 poisoned by S. carpinifolia. Similar lesions were also reported in cases of poisoning by plants that contain the alkaloid swainsonine, 1,3,4,9,10,12,20,22 as well as in cases of inherited alpha-mannosidosis in cattle, 21,39 humans, 29 domestic cats, 5,27 and the guinea pig.…”

Section: Discussionsupporting

confidence: 90%

“…24 S. carpinifolia, of the Malvaceae family, is a weed plant common in humid and shaded places, flourishing especially in pastures and wastelands. 23 This plant is responsible for producing lysosomal storage disease in goats, 7,13,19 ponies, 25 sheep, 33 and cattle. 16 The main clinical signs in goats, sheep, and cattle are incoordination with dysmetria and head tremors associated with frequent falls.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Furlan

Lucioli

Veronezi

et al. 2009

Veterinary Pathology

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Abstract. Clinical and pathologic findings for the spontaneous poisoning by Sida carpinifolia in cattle are described in this study. A survey on field cases of S. carpinifolia in cattle was carried out on farms of Alto Vale do Itajaí, State of Santa Catarina, southern Brazil. Sixteen affected animals were clinically evaluated and 9 were subjected to postmortem examination. The main clinical signs consisted of marching gait, alert gaze, head tremors, and poor growth. Histologic and ultrastructural lesions consisted of vacuolization and distension of neuronal perikarya, mainly from Purkinje cells, and of the cytoplasm of acinar pancreatic and thyroid follicular cells. Clinical signs and lesions varied from mild to severe. Improvement of the clinical signs was observed in cattle after a period of up to 90 days without consuming the plant; however, residual lesions, mainly characterized by axonal spheroids and absence of Purkinje neurons in some areas of the cerebellum, were observed in these cases. It is concluded that the natural chronic consumption of S. carpinifolia was the etiologic cause of storage disease in cattle in this study.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Furlan

Lucioli

Veronezi

et al. 2009

Veterinary Pathology

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“…Vacuolização neuronal de aspecto finamente granular não é um achado específico da intoxicação por S. fastigiatum e ocorre em outras doenças de herbívoros causadas pela ingestão de plantas do gênero Solanum (Pienaar et al 1976, Menzies et al 1979, Bourke 1997, Porter et al 2003, Swainsona, Oxytropis, Astragalus (Summers et al 1995), Ipomoea (Van der Lugt 2002) e Sida (Driemeier et al 2000, Loretti et al 2003b, Furlan 2005, Seitz et al 2005); e nas DDL hereditárias (Jolly & Walkley 1997). Intoxicação por Prosopis juliflora e pelo fungo Aspergillus clavatus não são DDL, mas induzem vacuolização neuronal em neurônios do tronco encefálico de bovinos.…”

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“…A documentação da ocorrência de glicogenose hereditária em bovinos Brahman (Zlotowski et al 2005 (Driemeier et al 2000), lipofuscinose causada por Phalaris angusta (Barros et al 2006) e uma neurolipidose causada por Solanum fastigiatum (RietCorrea et al 1983b, Barros et al1987, Paulovich et al 2002.…”

Section: Introdução Introdução Introdução Introdução Introduçãounclassified

Intoxicação por Solanum fastigiatum (Solanaceae) em bovinos: epidemiologia, sinais clínicos e morfometria das lesões cerebelares

et al. 2006

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Os bovinos afetados tinham idade média de 5 anos (2-8 anos) e a evolução clínica variou de 3-18 meses. Os sinais clínicos observados em todos os bovinos foram de disfunções cerebelares caracterizadas por hipermetria, incoordenação, quedas, tremores musculares, convulsões esporádicas e permanência em estação com os membros em base ampla. Em um bovino foi observada hemorragia traumática subdural no encéfalo e em outro, atrofia macroscópica do cerebelo. As lesões histológicas eram confinadas ao cerebelo e consistiram de vacuolização parcial ou total do pericário dos neurônios de Purkinje com ocasionais esferóides axonais na camada de células granulares e na substância branca cerebelar. Nos casos avançados, havia acentuada perda dos neurônios de Pukinje e proliferação dos astrócitos de Bergmann. O estudo morfométrico do número de neurônios de Purkinje e da espessura da camada molecular revelou um decréscimo no número de células de Purkinje que se correlacionou com conseqüente diminuição da espessura da camada molecular. Nineteen cases of Solanum fastigiatum (Solanaceae) poisoning in cattle from three municipalites in the State of Rio Grande do Sul, Brazil, occurring from 2003 to 2005, are described. Morbidity and mortality rates were respectively 6.7% and 3.4%. Average age of affected cattle was five-yearold (2 to 8-year-old) and duration of clinical courses was 3-18 months. Clinical signs observed in all affected cattle were cerebellar deficits characterized by hypermetry, incoordination, falls, muscle tremors, transitory seizures and wide base stance. One affected bovine had encephalic traumatic subdural hemorrhage and another had gross atrophy of the cerebellum. Histologically, lesions were restricted to the cerebellum and consisted of partial or complete vacuolation of the perikaria of Purkinje neurons with occasional axonal spheroids in the granular cell layer and in the white matter of the cerebellum. In advanced cases there were extensive loss of cerebellar Purkinje neurons and proliferation of the Bergmann's glia. The morphometric evaluation of the numbers of Purkinje neurons and of the thickness of the cerebellar molecular layer indicated decreased numbers of Purkinje neurons with consequent decrease in the molecular layer thickness.INDEX TERMS: Poisonous plants, Solanum fastigiatum, Solanaceae, lysosomal storage diseases, central nervous system, diseases of cattle, neuropathology.

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“…Nas regiões Sul e Sudeste, esse grupo é representado por Sida carpinifolia, que causa intoxicação em caprinos, ovinos, bovinos e equinos (Driemeier et al 2000, Colodel et al 2002a, 2002b, Loretti et al 2003. Na Ilha de Marajó, a intoxicação por I. carnea subsp.…”

Section: Introductionunclassified

Biópsia hepática como método diagnóstico para intoxicação por plantas que contém swainsonina

et al. 2016

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RESUMO.-Neste trabalho objetivou-se avaliar a técnica de biópsia hepática como um teste de valor diagnóstico para intoxicações por plantas que contém swainsonina.Para isso, reproduziu-se experimentalmente a doença com as folhas secas de Ipomoea marcellia contendo 0,02% de swainsonina em caprinos. O Grupo I foi constituído por 6 caprinos que receberam a planta misturada a ração na dose de 4g/kg (0,8mg de swainsonina/kg) até a observação dos primeiros sinais clínicos neurológicos. Outros dois caprinos que não receberam a planta na dieta constituíram o grupo controle (Grupo II). Foram realizadas biópsias hepá-ticas pela técnica percutânea cega com agulha de Menghini, no dia zero e com intervalos semanais nos caprinos do experimento. As biópsias hepáticas foram fixadas em formol tamponado 10%, processadas rotineiramente, coradas pela hematoxilina-eosina e histoquímica de lectinas. Vacuolização hepatocelular similar àquelas descritas em caso de doença de depósito lisossomal foram identificadas em todos os caprinos do Grupo I no 7º dia de experimento nas amostras coradas pela hematoxilina-eosina. With the aim to investigate the use of hepatic biopsies for the diagnosis of poisoning by swainsonine-containing plants, dry leaves of Ipomoea marcellia containing 0.02% of swainsonine were administered to goats. Group I, with six goats, ingested 4g/kg of dry plant (0.8mg of swainsonina/kg) daily until the observation of the first neurologic signs. Two goats that did not receive the plant were used as control (Group II). Hepatic biopsies with the Menghini needle were performed by the percutaneous technique at day zero and at weekly intervals after the start of the administration of I. marcellia. Biopsy samples were fixed in 10% formaline, processed routinely, and stained by hematoxilin-eosin and by lectins histochemistry. Hepatocellular vacuolization similar to those described in cases of lysosomal storage disease were identified in all goats of Group I from the seven day of plant consumption in the samples satained with hematoxylin-eosin. Using lectin histochemistry, consistent labellings were observed with Concanavalia ensiformis (Con-A) e Triticum vulgaris (WGA). It is concluded that routinely histological evaluation of liver biopsies can be used in the diagnosis of poisoning by swainsonine containing plants, even in goats without clinical signs, and lectin histochemistry which can be used as supplementary diagnostic method.INDEX TERMS: Poisonous plants, lysosomal storage disease, swainsonina, plant poisoning, liver biopsy.

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Lysosomal Storage Disease Caused bySida carpinifoliaPoisoning in Goats

Cited by 70 publications

References 23 publications

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Spontaneous Lysosomal Storage Disease Caused by Sida carpinifolia (Malvaceae) Poisoning in Cattle

Intoxicação por Solanum fastigiatum (Solanaceae) em bovinos: epidemiologia, sinais clínicos e morfometria das lesões cerebelares

Biópsia hepática como método diagnóstico para intoxicação por plantas que contém swainsonina

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