Lysosomes: Distribution in Animals, Hydrolytic Capacity and Other Properties

Tappel, Al L.; Sawant, P. L.; Shibko, S.

doi:10.1002/9780470715314.ch3

Cited by 63 publications

(15 citation statements)

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“…Lysosomes were regarded as a most sensitive index of neuronal damage by Becker and Barron 11961 ] and the increase in the lysosomal enzymes had been correlated with the excretion of tissue break-down products of urine in vitam in Edcficient rabbits by Tappel et al [ 1963]. In the present investigation a noticeable increase of this enzyme in the abnorm al fetuses has been observed.…”

Section: Discussionsupporting

confidence: 62%

Disorders of the developing nervous system of vitamin E-deficient rats

Verma¹,

D²

1967

Cells Tissues Organs

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Section: Discussionsupporting

confidence: 62%

Disorders of the developing nervous system of vitamin E-deficient rats

Verma¹,

D²

1967

Cells Tissues Organs

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“…might contain phosphorus atoms in mentionable amounts and that the P concentration in the released enzyme fraction might exceed that of the limiting lysoso mal membranes [ 18). On the other hand, secondary lyso somes arc known to be the site of intracellular digestion on account of which they are equipped with numerous hydrolytic enzymes.…”

Section: Discussionmentioning

confidence: 99%

The Phosphorus Content of Lysosomes in Hepatocytes and Kupffer Cells

Köpf-Maier

1990

Cells Tissues Organs

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In the present study, the distribution of phosphorus was analyzed within lysosomes of hepatocytes, Kupffer cells and mast cells in untreated liver tissue of mice by the use of electron-spectroscopic imaging, a new electron-microscopical method which combines microanalysis with ultrastructural representation and allows to image the spatial distribution of light elements such as· N or P in cells and tissues. The obtained analytical data unfolded marked differences regarding the phosphorus content of lysosomes within hepatocytes. Whereas peribiliary bodies always included phosphorus highly condensed in a coarse-granular distribution, the lysosomes apart from biliary capillaries contained different amounts of phosphorus, varying from high concentration to moderate and negligible amounts appearing as dust-like powder in the lysosomal interior. In contrast, the lysosomes of Kupffer cells always comprised phosphorus in high density and similar concentration as it is found in cytoplasmic ribosomes. These results confirm a pronounced and unexpected heterogeneity regarding the elemental composition of lysosomes in hepatocytes and Kupffer cells. It may be assumed that this heterogeneity is not accidental but based on differences in the functional state of lysosomes and the activity of their hydrolytic enzymes.

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“…In our previous studies concerning the effects of irradiation of rat embryo brains, we have shown various degrees of quantitative and qualitative changes of lysosomes particularly in association with pre-and necrobiotic processes (29,30). Lysosomal damage following irradiations was also observed by several investigators in the spleen (31), lymphatic cells (21), liver (32), and neurons (following whole body irradiation, 18).…”

Section: Discussionmentioning

confidence: 97%