Lysozyme – occurrence in nature, biological properties and possible applications

Gajda, Ewa; Bugla-Płoskońska, Gabriela

doi:10.5604/17322693.1133100

Cited by 19 publications

(13 citation statements)

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“…Lysozyme is a ubiquitous peptide that is widely distributed in animals, plants, bacteria and viruses ( 54 ). The antibacterial, immunomodulatory and antiviral functions of lysozyme are well-known in vertebrates ( 55 – 57 ).…”

Section: Insect Amps With Antiviral Activities: the Insect Avps In Pumentioning

confidence: 99%

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

et al. 2020

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Antimicrobial peptides (AMPs) with antiviral activity (antiviral peptides: AVPs) have become a research hotspot and already show immense potential to become pharmaceutically available antiviral drugs. AVPs have exhibited huge potential in inhibiting viruses by targeting various stages of their life cycle. Insects are the most speciose group of animals that inhabit almost all ecosystems and habitats on the land and are a rich source of natural AMPs. However, insect AVP mining, functional research, and drug development are still in their infancy. This review aims to summarize the currently validated insect AVPs, explore potential new insect AVPs and to discuss their possible mechanism of synthesis and action, with a view to providing clues to unravel the mechanisms of insect antiviral immunity and to develop insect AVP-derived antiviral drugs.

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Section: Insect Amps With Antiviral Activities: the Insect Avps In Pumentioning

confidence: 99%

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

et al. 2020

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“…Antimicrobial action of lysozyme is based on the hydrolysis of β-(1,4)-glycoside bond between C1 carbon of N-acetylmuramic acid (NAME) and C4 carbon atom of N-acetylglucosamine (NAG) within the peptidoglycan of the cell wall (15) (16). However, it also kills microorganisms by the non-enzymatic mechanism.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy

et al. 2019

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This observational clinical study was composed of two substudies: a non-comparative one (n = 166), testing only lysozyme-based compounds (LBCs), and a comparative substudy (n = 275), testing both LBCs and bicarbonate-based local compounds (BBCs) on the healing of oral mucositis during radio- or chemotherapy. The density of ulcerations has decreased significantly after the treatment with lysozyme in both substudies. The density of ulcerations in the radiotherapy group was lower in patients treated with LBCs compared to patients treated with BBCs (p < 0.001). In the chemotherapy group, reduction of ulceration density was similar with both LBCs and BBCs. The LBCs reduced pain intensity during the intake of solid food and speech more than BBCs in both patient cohorts (p < 0.05). In the radiotherapy cohort, pain intensity when consuming liquid foods was reduced more with LBCs than with BBCs (p < 0.05). No adverse events were recorded. This study demonstrates the advantages of treating oral mucositis during radiotherapy or chemo-therapy with LBCs.

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“…The bond consisting of β-(1,4)-linked N-acetylglucosamine and N-acetylmuramic acid is broken by lysozyme. Disulphide bonds in spatial lysozyme conformation are responsible for its high thermostability [19]. …”

Section: Characteristics Of Antimicrobial Endogenous Factorsmentioning

confidence: 99%

Endogenous antimicrobial factors in the treatment of infectious diseases

Żelechowska¹,

Agier²,

Brzezińska‐Błaszczyk³

2016

cejoi

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Nowadays, a number of antibiotic-resistant bacteria strains is increasing. It is a serious clinical problem and poses a threat to the effectiveness of conventional antibiotic therapy. Thus, scientists are constantly seeking new alternatives for treatment of infectious diseases. There are some natural endogenous factors, which possess antimicrobial activities against a large number of microorganisms, including both Gram-positive and Gram-negative bacteria, viruses and fungi. These factors are present in all eukaryotic organisms and constitute an essential element of their immune system. A large number of in vitro and in vivo models have been used to show the activity of antimicrobial factors, and only few studies have been conducted on people. Results indicate that administration of these molecules is therapeutically beneficial. This review summarizes knowledge of selected endogenous antimicrobial agents, such as cathelicidins, defensins, histatins, lysozyme and lactoferrin. We also discuss potential uses of these factors in the treatment of infectious diseases.

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Lysozyme – occurrence in nature, biological properties and possible applications

Cited by 19 publications

References 0 publications

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

Antimicrobial Peptides as Potential Antiviral Factors in Insect Antiviral Immune Response

Efficacy and safety of local lysozyme treatment in patients with oral mucositis after chemotherapy and radiotherapy

Endogenous antimicrobial factors in the treatment of infectious diseases

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