M-proteins, plasmacytosis and cancer

Hosley, Henry F.

doi:10.1002/1097-0142(1967)20:2<295::aid-cncr2820200217>3.0.co;2-1

Cited by 32 publications

(5 citation statements)

References 22 publications

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“…The occurrence of Bence Jones proteinuria outside myelomatosis and primary macroglobulinemia bas been repeatedly reported in patients with malignant tumors and skeletal metastases (6,16,19,22). In our subjects with benign monoclonal gammapathies and a urinary light chain component, thorough clinical and laboratory examinations were carried out after the discovery of the urinary abnormalities.…”

Section: Discussionmentioning

confidence: 96%

Bence Jones Proteinuria in Benign Monoclonal Gammapathies

Dammacco

Waldenström

1968

Journal of Internal Medicine

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The possibility and the extent to which detection of Bence Jones proteinuria might be used as a clinical differential criterion between benign and malignant monoclonal gammapathies has been investigated. Clinical and laboratory studies were carried out in 42 subjects with an “essential” serum M‐component and, by comparison, in 46 patients with myelomatosis and in ten with macroglobulinemia Waldenström. The heat precipitation test was found weakly positive in only one urine sample from the benign cases (2.3%), as compared with 32.6% of the myeloma cases and 20% of those with macroglobulinemia. However, by combining agarose‐electrophoresis and immunoelectrophoresis of concentrated urine, a urinary light chain component was demonstrated in 23.8% of the benign gammapathies. For myelomatosis and primary macroglobulinemia the corresponding figures were 67.3% and 60%, respectively. The amount of Bence Jones proteinuria never exceeded 60 mg/1 in the benign forms, whereas in the malignant forms it changed considerably from case to case and could reach values of as much as 10 g/1. Wide variations of pH and temperature were studied for their effect upon the thermal behaviour of two kappa‐type Bence Jones proteins, isolated from the urines of two subjects with benign monoclonal gammapathies. Within the limits investigated the physico‐chemical properties of these benign‐type Bence Jones proteins did not differ apparently from those described as characteristic of Bence Jones protein in myelomatosis. The kappa/lambda ratio of the serum M‐components in the “essential” cases did not show any preferential synthesis as compared with myelomatosis and normal immunoglobulins. This indicates that the benign monoclonal mutation of kappa‐ and lambda‐synthesizing cells may develop at a rate proportional to their normal occurrence.

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Section: Discussionmentioning

confidence: 96%

Bence Jones Proteinuria in Benign Monoclonal Gammapathies

Dammacco

Waldenström

1968

Journal of Internal Medicine

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“…Another postulated relationship is that cancer and myeloma in some patients might have a common etiology, such as a genetic defect or a common carcinogen. 9 Although the extent and nature of the association between myeloma and carcinoma remains obscure, a review of the literature suggests that such an association may occur more frequently than has previously been supposed and further investigation would appear warranted.…”

Section: Discussionmentioning

confidence: 99%

Multiple myeloma associated with a 9S IgG paraprotein and carcinoma of the prostate

Chin¹,

Smith²,

Wright³

et al. 1972

Cancer

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A case of multiple myeloma associated with a 9S IgG complex. kappa‐type light chains, and adenocarcinoma of the prostate is described. The relative amount of 9S globulin was independent of total protein concentration; it was the predominant M‐component in both highly diluted serum and also in whole serum. At low pH, it was dissociated to the 7S monomer. The presence of moderately high concentrations of the 9S species in the patient's serum did not cause symptoms of the hyperviscosity syndrome. A review of the literature suggests that the association of myeloma with nonreticular neoplasms may occur more often than previously supposed.

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“…In another patient (Case 17) the coexistence of gastric cancer and IgG myeloma was observed. It remains to be determined whether the association of M -components with epithelial neoplasms implies a causal relationship44, 70 Idiopathic; aging and miscellaneous diseases (III, 1-2): M-components in this category are of idiopathic nature; that is, no specific diseases related to the appearance of M-components are apparent.…”

Section: Classification Of Monoclonal Gammopathiesmentioning

confidence: 99%

The Behavior of Immunoglobulin in Monoclonal Gammopathies and Their Classification and Pathogenesis

Kanoh

1970

Tohoku J. Exp. Med.

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M-proteins, plasmacytosis and cancer

Cited by 32 publications

References 22 publications

Bence Jones Proteinuria in Benign Monoclonal Gammapathies

Bence Jones Proteinuria in Benign Monoclonal Gammapathies

Multiple myeloma associated with a 9S IgG paraprotein and carcinoma of the prostate

The Behavior of Immunoglobulin in Monoclonal Gammopathies and Their Classification and Pathogenesis

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