M2 macrophage-derived exosome-encapsulated microneedles with mild photothermal therapy for accelerated diabetic wound healing

Zeng, Junkai; Sun, Zhenyu; Zeng, Feihui; Gu, Changjiang; Chen, Xiongsheng

doi:10.1016/j.mtbio.2023.100649

Cited by 27 publications

(15 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, modulation of macrophages could be employed to decrease the proportion of M1 macrophages during the inflammatory phase and enhance the ratio of M2 macrophages. This approach aims to abbreviate the inflammatory stage in the healing process of diabetic wounds, consequently contributing to the therapeutic intervention of diabetic wounds 41,42 . All in all, targeting macrophage functions might be a promising strategy for wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…However, in the presence of conditions like diabetes, microvascular basement membrane thickening could occur, leading to the adhesion of inflammatory cells to the endothelium of micro‐vessels 70 . Additionally, reduced local blood supply could further result in ischaemia and hypoxia at the wound site, lowering infection resistance and disrupting the wound healing process, ultimately leading to chronic wounds 41,42 . Diabetic wounds are often utilized as models to study the characteristics of chronically non‐healing wounds.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Visualization of the relationship between macrophage and wound healing from the perspective of bibliometric analysis

Guo,

Li,

Xie

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

Macrophages play a crucial role in aiding all phases of the wound‐healing process and has garnered increasing attention recently. Although a substantial body of related studies has been published, there remains a lack of comprehensive bibliometric analysis. In this study, we collected 4296 papers from the Web of Science Core Collection database. Three tools including CiteSpace, VOSviewer and one online analytical platform were employed to conduct bibliometric analysis and data visualization. Our results revealed that the annual number of publications related to macrophage and wound healing has increased exponentially with the year. The United States and China stand as the primary driving forces within this field, collectively constituting 58.2% of the total publication output. The application of biomaterials was one of the most concerned research areas in this field. According to references analysis, the current research focus has shifted to diabetic wound healing and regulating macrophage polarization. Based on the keywords analysis, we identified the following research frontiers in the future: exosomes and other extracellular vesicles; bio‐derived materials and drug delivery methods such as nanoparticles, scaffolds and hydrogels; immunomodulation and macrophage polarization in the M2‐state; chronic wounds, particularly those associated with diabetes; antimicrobial peptides; and antioxidant. Additionally, TNF, IL‐6, IL‐10, TGF‐β1 and VEGF ranked as the five genes that have garnered the most research attention in the intersection of macrophage and wound healing. All in all, our findings offered researchers a holistic view of the ongoing progress in the field of macrophages and wound healing, serving as a valuable reference for scholars and policymakers in this domain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Visualization of the relationship between macrophage and wound healing from the perspective of bibliometric analysis

Guo,

Li,

Xie

et al. 2023

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…MNs can be inserted into the skin with a tiny needle (usually less than 1 mm in diameter) without damaging blood vessels or nerves, allowing for noninvasive, painless application. 115 In addition, MNs can be combined with biosensors, microcircuits, and microfluidic channels to achieve more complex and diverse functions. 116 Lu et al described a new coding structure composed of photonic crystals and MNs, known as a colored MN patch, which is designed to simultaneously detect three typical wound biomarkers, including pH, glucose, and histamine (Fig.…”

Section: Smart Hydrogels For Wound Monitoringmentioning

confidence: 99%

Recent advances of hydrogels as smart dressings for diabetic wounds

Wang,

Yang,

Zhao

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…They promote rapid wound healing through mechanisms involving angiogenesis promotion and inflammation modulation. 135–138 Yang et al conducted a study where they encapsulated exosomes derived from human umbilical cord mesenchymal stem cells (hUCMSC-exos) within a thermosensitive hydrogel called Pluronic F-127 (PF-127). They used a full-thickness wound model in diabetic rats and found that the combination of PF-127 hydrogel with hUCMSC-exos led to increased production of CD31 and upregulation of VEGF expression.…”

Section: Multiple Functions Of Hydrogel-based Dressingsmentioning

confidence: 99%