MACARANGIN, A GERANYLATED FLAVONOID AND ANTICANCER ACTIVE COMPOUND ISOLATED FROM ETHYL ACETAT FRACTION OF Macaranga gigantifolia LEAVES

Abstract

Macaranga known locally as mahang-mahangan has uniquely ecological function, and also became a part of traditional medicine in Indonesia. Macaranga genus also known as a sources of terpenoid and phenolic (flavonoid) compounds which have biological activity as antioxidant and anticancer (cytotoxicity).There are few phytochemical investigations have been done on M. gigantifolia species. As a part of our continuing research of isolation anticancer compound from natural product, a geranylated flavonoid compound (macarangin) has been isolated from ethyl acetate fraction of Macaranga gigantifolia leaves using chromatography methods. The isolated compund (isolat MG) was elucidated to gain the chemical structure based on spectroscopic data (LC-MS and FT-NMR). Cytotoxicity test of this compound was tested against MCF 7 cell lines, showed that macarangin has a potential activity with IC 50 value 119.12μg/mL.

Apigenin, an Anticancer Active Compound Isolated from Macaranga gigantifolia Leaves

“…Otherwise, Macaranga hypoleuca can be used as febrifuge, expectorant and antispasmodic and also has potential as an antioxidant, anti-bacterial [2], and anti-diabetic [3]. There are only two compounds (scopoletin and macarangin) have been isolated from M. gigantifolia so far [4][5]. A phytochemical review indicates the genus Macaranga to be a rich source of flavonoids [6].…”

Antiproliferative Activity of Triterpenoid and Steroid Compounds from Ethyl Acetate Extract of Calotropis gigantea Root Bark against P388 Murine Leukemia Cell Lines

“…A derivative compound of coumarin, scopoletin, isolated from the Macaranga gigantifolia Merr. Leaves, show strong cytotoxic activities against cell lines of P388 murine leukemia [31].…”

Chemophenetic Significance of Anomalocalyx uleanus Metabolites Are Revealed by Dereplication Using Molecular Networking Tools

“…In addition to Meliaceae, cinchonain Ib (33) has already been identified in several families, such as Elaeagnaceae [47], Hypericaceae [48], Lauraceae [49], Rhizophoraceae [50], Rosaceae [51], Rubiaceae [52], Smilacaceae [53], and Theaceae [54] Chlorogenic acid (25) and its derivatives are present in Euphorbiaceae and could be isolated from some species of Euphorbiaceae, such as Jatropha aethiopica [55], Euphorbia peplus [56], Euphorbia hirta, Phyllanthus emblica, Ricinus communis [57], Sapium insigne [58], and Croton antisyphiliticus [39]. Coumarins are relatively common in many Euphorbiaceae genera, such as Pedilanthus [59], Cnidoscolus [22], Macaranga [60], Mallotus [61], Phyllanthus [62], Jatropha [63], Euphorbia [64], and others. Four coumarins were detected in A. uleanus: aesculin (28), phyllocoumarin (29), fraxin (30), and fraxidin (31).…”