In this paper, the cooperation between human and robot companies plays a significant role in factories, contributing to greater productivity and efficiency. However, this development breaches established safety procedures when the workspaces are separated from the robot and the human being. These changes have been reflected in industrial robotic safety standards for the last 20 years. We have directed the expansion of a broad field of examination, which focuses on avoiding robotic humans’ effects and minimizing associated risks and consequences. The paper depicts an analysis of prominent safety systems projected and implemented in engineering robotic surroundings that contribute to safe, collective work between humans and robots. Besides, the current regulation has introduced a review and new concepts. The discussion includes multidisciplinary approaches such as estimating and evaluating human-robot collision injuries, mechanical equipment and software to minimize human-robot impacts, impact detection systems, and collision prevention strategies and minimizing their impact to proposed approach for Human Security with Mobile Robots in Industry 4.0 using SDN and CPS with GMM-GM machine learning model.