Technological Advances in Organ Transplantation 2017
DOI: 10.1007/978-3-319-62142-5_2
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Machine Perfusion of Organs

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“…NMP can expand the pool of available organs to include those of marginal initial quality, by enhancing graft assessment, preservation, and resuscitation, through constant supply of oxygen and nutrients as well as clearance of toxic metabolites. Currently, ex vivo kidney perfusion is the most highly developed extracorporeal perfusion technique, although liver, heart, intestine, and lung perfusion has also been introduced into clinical practice. In addition, machine perfusion of vascularized composite allografts, such as limbs, has created possibilities for transplantation or autologous reimplantation …”
Section: Organ Transplantation As a Notable Medical Application For N...mentioning
confidence: 99%
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“…NMP can expand the pool of available organs to include those of marginal initial quality, by enhancing graft assessment, preservation, and resuscitation, through constant supply of oxygen and nutrients as well as clearance of toxic metabolites. Currently, ex vivo kidney perfusion is the most highly developed extracorporeal perfusion technique, although liver, heart, intestine, and lung perfusion has also been introduced into clinical practice. In addition, machine perfusion of vascularized composite allografts, such as limbs, has created possibilities for transplantation or autologous reimplantation …”
Section: Organ Transplantation As a Notable Medical Application For N...mentioning
confidence: 99%
“…139−143 In addition, machine perfusion of vascularized composite allografts, such as limbs, has created possibilities for transplantation or autologous reimplantation. 144 NMP is an ideal process by which therapeutics can be delivered directly to the organ, prior to its implantation in the recipient, in a localized, sustained, and controlled fashion 87 (Figure 1). Therefore, this modality can be explored to overcome the limitations of in vivo administration, as discussed earlier.…”
Section: Organ Transplantation As a Notable Medical Application For N...mentioning
confidence: 99%