In the industrial cutting of alloy GH4169, high cutting force and temperature have always been important factors affecting machining quality and efficiency. In view of this, this study aims to improve the cutting performance of the alloy GH4169, and special attention was given to the changes in cutting force and temperatures under different parameters with ceramic turning experiments, and the optimal cutting parameters were determined based on orthogonal experimental design. The work findings indicate that the resultant force initially increased and then declined with the increase of cutting speed, while it showed increasing trend with the increased of both feed rate and depth of cut. Meanwhile, cutting temperature was positive related to both the cutting speed, feed rate and depth of cut. Based on the range analysis and variance analysis, the depth of cut had the greatest impact on the resultant force and cutting temperature, followed by cutting speed and feed rate, and only the depth of cut significantly affected the changes in resultant force and cutting temperature. Finally, an optimal cutting condition with the lowest resultant force and temperature was determined, where cutting speed is 150 m/min, feed rate is 0.05 mm/r, and depth of cut is 0.1 mm. It is proposed to be used in the industrial machining of alloys GH4169 for the grater product quality and benefits.