“…Phytochemical investigation of CH 2 Cl 2 crude extract from the bark of G. schomburgkiana led to the isolation of two new xanthone derivatives, named schomburgones A ( 1 ) and B ( 2 ), along with eight known compounds (Fig. 1), including isocudraniaxanthone B ( 3 ) [4], gerontoxanthone I ( 4 ) [5], nigrolineaxanthone E ( 5 ) [6], isojacareubin ( 6 ) [7], dulxanthone A ( 7 ) [8], macluraxanthone ( 8 ) [9], vismiaquinone A ( 9 ) [10], and 3-geranylemodin ( 10 ) [11]. The structures of all isolated compounds were elucidated using spectroscopic methods especially NMR spectroscopies and compared with their 1 H and 13 C NMR spectroscopic data from the literature.Fig.…”
Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3-8) and anthraquinones (9-10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3-6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC values in the range of 1.45-9.46 µM.
“…Phytochemical investigation of CH 2 Cl 2 crude extract from the bark of G. schomburgkiana led to the isolation of two new xanthone derivatives, named schomburgones A ( 1 ) and B ( 2 ), along with eight known compounds (Fig. 1), including isocudraniaxanthone B ( 3 ) [4], gerontoxanthone I ( 4 ) [5], nigrolineaxanthone E ( 5 ) [6], isojacareubin ( 6 ) [7], dulxanthone A ( 7 ) [8], macluraxanthone ( 8 ) [9], vismiaquinone A ( 9 ) [10], and 3-geranylemodin ( 10 ) [11]. The structures of all isolated compounds were elucidated using spectroscopic methods especially NMR spectroscopies and compared with their 1 H and 13 C NMR spectroscopic data from the literature.Fig.…”
Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3-8) and anthraquinones (9-10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 3-6 and 8 showed good cytotoxicity against all the five cancer cell lines with IC values in the range of 1.45-9.46 µM.
This review, with 350 references, gives information on the chemical study of 234 naturally occurring tetraoxygenated xanthones in 12 families, 53 genus and 182 species of higher plants, and two which are described as fungal and lichen metabolites. The value of these groups of substances in connection with pharmacological activity and therapeutic use of some species is described. The structural formulas of 135 isolated compounds, and their distribution, are also given.
“…The HMBC correlations (Figure 2) of 1-OH (δ 13.32) with C-1 (δ 158.6), C-2 (δ 109.1) and C-9a (δ 109.2); 3-OH (δ 6.48) with C-2 (δ 109.1), C-3 (δ 160.6) and C-4 (δ 105.4); 6-OH (δ 6.42) with C-5 (δ 133.7), C-6 (δ 149.6) and C-7 (δ 112.2); and 5-OMe (δ 4.12) with C-5 (δ 133.7) also supported the 1,3,5,6-tetraoxygenated xanthone core structure. Resonances for a set of ortho-coupled aromatic protons [δ 7.96 and 7.01 (each 1H, d, J = 8.8 Hz)] were assigned to H-8 and H-7 due to the HMBC correlations (Figure 2) of H-7 (δ 7.01) with C-4b (δ 154.2), C-5 (δ 133.7) and The known compounds were characterized from spectroscopic data, as well as by comparison of NMR spectral data with known compounds as 10-O-methylmacluraxanthone (2) [15], macluraxanthone (3) [16], cudraxanthone Q (4) [17], 5-Omethylxanthone V 1 (5) [18], trapezifolixanthone (6) [19], cudraxanthone L (7) [20], dulxanthone B (8) [11], doitunggarcinone C (9) [3a], 1,5-dihydroxy xanthone (10) [21], caloxanthone L (11) [22], isobractatin (12) [23], forbesione (13) [24], bractatin ( 14) [23], neobractatin ( 15) [25] and xerophenone A ( 16) [26]. Some of the isolated compounds were evaluated for their antibacterial activity (Table 1) against Gram-positive bacteria (Bacillus cereus TISTR 688 and B. subtilis TISTR 088) and Gramnegative bacteria (Escherichia coli TISTR 780 and Salmonella typhimurium TISTR 292).…”
Phytochemical investigation of Garcinia propinqua roots led to the isolation and identification of a new xanthone, doitunggarcinone D (1), together with 15 known compounds (2–16). Their structures were elucidated by intensive analysis of spectroscopic data. Compounds 3, 6, 7, 14, 15 and 16 exhibited strong antibacterial activity against Bacillus subtilis TISTR 088 with MIC values in the range of 1–4 μg/mL. Compounds 3, 7, 10 and 14 also showed good antibacterial activity against B. cereus TISTR 688 with MIC values ranging from 4–8 μg/mL.
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