Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling pathways

Lee, Yu Jin; Jung, Okkeun; Lee, Jongsung; Son, Juhyeon; Cho, Jae Youl; Ryou, Chongsuk; Lee, Sang Yeol

doi:10.1016/j.nutres.2018.07.003

Cited by 24 publications

(21 citation statements)

References 35 publications

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“…Also, despite our results indicating a correlation with the presence of xanthonoids and gallates and the cytotoxic activity in tumoral cell lines, these compounds are probably not the only factors responsible for the observed biological effects. The contribution of other components present in the extracts should be clarified because reports in the literature of similar anti-cancer properties are available for phenolic acids and flavonoids [75,76] and hydroxybenzophenones [77].…”

Section: Resultsmentioning

confidence: 99%

Polyphenolic Characterization, Antioxidant, and Cytotoxic Activities of Mangifera indica Cultivars from Costa Rica

Navarro

Arnáez

Moreira

et al. 2019

Foods

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The phenolic profile of skin and flesh from Manifera indica main commercial cultivars (Keitt and Tommy Atkins) in Costa Rica was studied using ultra performance liquid chromatography coupled with high resolution mass spectrometry (UPLC-ESI-MS) on enriched phenolic extracts. A total of 71 different compounds were identified, including 32 gallates and gallotannins (of different polymerization degree, from galloyl hexose monomer up to decagalloyl hexoses and undecagalloyl hexoses); seven hydroxybenzophenone (maclurin and iriflophenone) derivatives, six xanthonoids (including isomangiferin and mangiferin derivatives); 11 phenolic acids (hydroxybenzoic and hydroxycinnamic acid derivatives); and eight flavonoids (rhamnetin and quercetin derivatives). The findings for T. Atkins skin constitute the first report of such a high number and diversity of compounds. Also, it is the first time that the presence of gallotannin decamers and undecamers are reported in the skin and flesh of Keitt cultivar and in T. Atkins skins. In addition, total phenolic content (TPC) was measured with high values especially for fruits’ skins, with a TPC of 698.65 and 644.17 mg gallic acid equivalents/g extract, respectively, for Keitt and T. Atkins cultivars. Antioxidant potential using 2,2-diphenyl-1-picrylhidrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) methods were evaluated, with T. Atkins skin showing the best values for both DPPH (IC50 = 9.97 µg/mL) and ORAC (11.02 mmol TE/g extract). A significant negative correlation was found for samples between TPC and DPPH antioxidant values (r = −0.960, p < 0.05), as well as a significant positive correlation between TPC and ORAC (r = 0.910, p < 0.05) and between DPPH and ORAC antioxidant methods (r = 0.989, p < 0.05). Also, cytotoxicity was evaluated in gastric adenocarcinoma (AGS), hepatocarcinoma (HepG2), and colon adenocarcinoma (SW620), with T. Atkins skin showing the best results (IC50 = 138–175 µg/mL). Finally, for AGS and SW 620 cell lines particularly, a high significant negative correlation was found between cytotoxic activity and gallotannins (r = −0.977 and r = −0.940, respectively) while for the HepG2 cell line, the highest significant negative correlation was found with xanthonoids compounds (r = −0.921).

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Section: Resultsmentioning

confidence: 99%

Polyphenolic Characterization, Antioxidant, and Cytotoxic Activities of Mangifera indica Cultivars from Costa Rica

Navarro

Arnáez

Moreira

et al. 2019

Foods

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“…Although no bioactive properties have been ascribed so far to this C-glycosylated compound, the aglycone maclurin has been reported to exhibit antioxidant activity, anti-cancer effects and suppression of enzymatic browning. 39,40 Despite the similarity of the qualitative profiles in both types of extracts, significant differences were observed regarding the total amount of phenolic compounds and each individual compound ( p < 0.05), with a higher extraction yield being achieved when using a mixture of ethanol : water as the extraction solvent. Previous data on the phenolic composition of methanolic extracts of L. officinale leaves have been recently reported by Złotek et al 42 The authors reported the tentative identification of a total of 14 phenolic compounds, some being identical to the ones also reported in this work, such as 4-O and 5-O-caffeoylquinic acids and rutin.…”

Section: Chemical Characterization Of L Officinale Extractsmentioning

confidence: 94%

Chemical and bioactive characterization of the aromatic plant Levisticum officinale W.D.J. Koch: a comprehensive study

et al. 2020

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“…T24 cell is derived from transitional cell carcinoma grade II, whereas the PC-3 cell line is derived from bone metastasis from grade IV adenocarcinoma. Thus, the PC-3 cell is more malignant and resistant to treatment 86 . Similar results were verified by Carvalho et al 87 .…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Botteon

Silva

Ccana-Ccapatinta

et al. 2021

Sci Rep

165

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Gold nanoparticles (AuNPs) are highlighted due to their low toxicity, compatibility with the human body, high surface area to volume ratio, and surfaces that can be easily modified with ligands. Biosynthesis of AuNPs using plant extract is considered a simple, low-cost, and eco-friendly approach. Brazilian Red Propolis (BRP), a product of bees, exhibits anti-inflammatory, anti-tumor, antioxidant, and antimicrobial activities. Here, we described the biosynthesis of AuNPs using BRP extract (AuNPextract) and its fractions (AuNPhexane, AuNPdichloromethane, AuNPethyl acetate) and evaluated their structural properties and their potential against microorganisms and cancer cells. AuNPs showed a surface plasmon resonance (SPR) band at 535 nm. The sizes and morphologies were influenced by the BRP sample used in the reaction. FTIR and TGA revealed the involvement of bioactive compounds from BRP extract or its fractions in the synthesis and stabilization of AuNPs. AuNPdichloromethane and AuNPhexane exhibited antimicrobial activities against all strains tested, showing their efficacy as antimicrobial agents to treat infectious diseases. AuNPs showed dose-dependent cytotoxic activity both in T24 and PC-3 cells. AuNPdichloromethane and AuNPextract exhibited the highest in vitro cytotoxic effect. Also, the cytotoxicity of biogenic nanoparticles was induced by mechanisms associated with apoptosis. The results highlight a potential low-cost green method using Brazilian red propolis to synthesize AuNPs, which demonstrated significant biological properties.

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Maclurin exerts anti-cancer effects on PC3 human prostate cancer cells via activation of p38 and inhibitions of JNK, FAK, AKT, and c-Myc signaling pathways

Cited by 24 publications

References 35 publications

Polyphenolic Characterization, Antioxidant, and Cytotoxic Activities of Mangifera indica Cultivars from Costa Rica

Polyphenolic Characterization, Antioxidant, and Cytotoxic Activities of Mangifera indica Cultivars from Costa Rica

Chemical and bioactive characterization of the aromatic plant Levisticum officinale W.D.J. Koch: a comprehensive study

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

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