Macroglial cells of the teleost central nervous system: a survey of the main types

Cuoghi, Barbara; Mola, Lucrezia

doi:10.1007/s00441-009-0870-2

Cited by 36 publications

(30 citation statements)

References 84 publications

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“…The present data suggests that in the trout telencephalon CBS may label aNSCs with a glial phenotype (radial glia). Our assumption is consistent with the results of studies of the pallial neurogenic niche in adult zebrafish containing radial glia-like aNSCs with cellular bodies lining the walls of the ventricle [19]. Studies of the hydrogen sulfide biology in the mammalian brain have shown that astrocytes and glial cells constitute the main repositories of CBS in the brain [3].…”

Section: Telencephalonsupporting

confidence: 90%

Hydrogen Sulfide as a Factor of Neuroprotection during the Constitutive and Reparative Neurogenesis in Fish Brain

Пущина¹,

Вараксин²,

Обухов³

2020

Neuroprotection - New Approaches and Prospects

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The H 2 S-producing systems were studied in trout telencephalon, tectum, and cerebellum at 1 week after eye injury. The results of ELISA analysis have shown a 1.7-fold increase in the CBS expression at 1 week post-injury, as compared to the intact trout. In the ventricular and subventricular regions of trout telencephalon, CBS+ cells, as well as neuroepithelial and glial types, were detected. As a result of injury, the number of CBS+ neuroepithelial cells in the pallial and subpallial periventricular regions of the telencephalon increases. In the tectum, a traumatic damage leads to an increase in the CBS expression in radial glia with a simultaneous decrease in the number of CBS immunopositive neuroepithelial cells detected in intact animals. In the cerebellum, we revealed neuroglial interrelations, in which H 2 S is probably released from the astrocyte-like cells with subsequent activation of the neuronal NMDA receptors. The organization of the H 2 S-producing cell complexes suggests that the amount of glutamate produced in the trout cerebellum and its reuptake is controlled with the involvement of astrocyte-like cells, reducing its excitotoxicity. We believe that the increase in the number of H 2 S-producing cells constitutes a response to oxidative stress, and the overproduction of H 2 S neutralizes the reactive oxygen species.2 completely clarified thus far. H 2 S, like nitric oxide (NO), is known to mediate posttranslational modification of proteins by adding additional sulfur to reactive cysteine residues. This modification, referred to as S-sulfhydration, is required to activate or inactivate many classes of proteins, including the ion channels, such as the ATP-dependent potassium channels, TRPV3, TRPV6, TRPM [6], enzymes, and the transcription factors NF-kB and Nrf2 [7]. Modulation of ion channels, as well as the inflammatory and the antioxidant transcription factors, using H 2 S after traumatic brain injury, can play a significant role in reducing edema and inflammation [8].Recently, the involvement of H 2 S in cerebral ischemia, traumatic brain injury (TBI), and decrease in reactive oxygen species in the H 2 S-dependent mechanisms has been studied using different models [8][9][10]. The use of monoclonal antibodies against cystathionine β-synthase (CBS) in immunohistochemical (IHC) detection of the H 2 S-producing complexes in the brain of juvenile trout showed an increase in hydrogen sulfide production in different parts of the brain and CBS induction in the radial glia cells after the damage of the optic nerve [11]. It was shown that the toxic and/or neuroprotective effects of hydrogen sulfide depended on concentration: lower concentrations play a physiological role, while very high concentrations cause cell death [12,13]. Although hydrogen sulfide is considered a gasotransmitter, there is uncertainty about the total concentration of this volatile gas or highly active anionic particles (SH-) in both plasma and central nervous system tissues [14].The progress in studies of the hydrogen sulfide biology h...

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Section: Telencephalonsupporting

confidence: 90%

Hydrogen Sulfide as a Factor of Neuroprotection during the Constitutive and Reparative Neurogenesis in Fish Brain

Пущина¹,

Вараксин²,

Обухов³

2020

Neuroprotection - New Approaches and Prospects

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“…12 The macroglial cells of the CNS include astrocytes, ependymal cells, and radial cells. 13 Astrocytes, which are also called "astroglia," connect the neurons to the blood vessels and may be an important part of the blood-brain barrier, control the extraneural space by removing ions and recycling neurotransmitters, and may also be involved in the regulation of vasodilatation and vasoconstriction. 10 Oligodendrocytes coat the axons such as the optic nerve fibers with myelin as electrical insulation.…”

Section: Microgliamentioning

confidence: 99%

Retinal Microglia in Glaucoma

Wang

Chen

Zhang

et al. 2016

Journal of Glaucoma

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“…, 2009). In fish, however, radial glia is the predominant glia type (Cuoghi & Mola, 2009) and retains its neurogenic function in adulthood. It is therefore of interest to explore whether also radial glia undergoes gliosis as function of age.…”

Section: Introductionmentioning

confidence: 99%

Adult neurogenesis in the short‐lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging

et al. 2012

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We studied adult neurogenesis in the short-lived annual fish Nothobranchius furzeri and quantified the effects of aging on the mitotic activity of the neuronal progenitors and the expression of glial fibrillary acid protein (GFAP) in the radial glia. The distribution of neurogenic niches is substantially similar to that of zebrafish and adult stem cells generate neurons, which persist in the adult brain. As opposed to zebrafish, however, the N. furzeri genome contains a doublecortin (DCX) gene. Doublecortin is transiently expressed by newly generated neurons in the telencephalon and optic tectum (OT). We also analyzed the expression of the microRNA miR-9 and miR-124 and found that they have complementary expression domains: miR-9 is expressed in the neurogenic niches of the telencephalon and the radial glia of the OT, while miR-124 is expressed in differentiated neurons. The main finding of this paper is the demonstration of an age-dependent decay in adult neurogenesis. Using unbiased stereological estimates of cell numbers, we detected an almost fivefold decrease in the number of mitotically active cells in the OT between young and old age. This reduced mitotic activity is paralleled by a reduction in DCX labeling. Finally, we detected a dramatic up-regulation of GFAP in the radial glia of the aged brain. This up-regulation is not paralleled by a similar up-regulation of S100B and Musashi-1, two other markers of the radial glia. In summary, the brain of N. furzeri replicates two typical hallmarks of mammalian aging: gliosis and reduced adult neurogenesis.

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Macroglial cells of the teleost central nervous system: a survey of the main types

Cited by 36 publications

References 84 publications

Hydrogen Sulfide as a Factor of Neuroprotection during the Constitutive and Reparative Neurogenesis in Fish Brain

Hydrogen Sulfide as a Factor of Neuroprotection during the Constitutive and Reparative Neurogenesis in Fish Brain

Retinal Microglia in Glaucoma

Adult neurogenesis in the short‐lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging

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