Macroglobulins in Chronic Pancreatitis and Liver Cirrhosis

Svartz, Nanna

doi:10.1001/jama.1967.03120240079012

Cited by 2 publications

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“…As has been reported in J.A.M.A. and elsewhere (10,11,13), the entire R F is not needed for the production of a positive sheep cell test (Svartz), but only a small fragment of it with a sedimentation constant of about 7 S (Fig. 8).…”

Section: Resultsmentioning

confidence: 56%

Two Methods for Producing in Animals a Macroglobulin Similar to the Rheumatoid Factor

Svartz¹,

Hedman²,

Söderberg³

1969

Journal of Internal Medicine

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Two methods for provoking a haemagglutinating macroglobulin identical or similar to the Rheumatoid factor (RF) are described. The macroglobulins were obtained (a) by injections of Diplostreptococcus agalactiae into animals, mainly white rats; ( b ) by injecting into rats the antibody to RF (anti-RF) or the active fraction of this antibody. The anti-RF was produced by immunizing rabbits against RF. Both (a) and ( b ) have given rise to haemagglutinating macroglobulins showing high titres (up to 1 : 1024) in the sheep cell test. The titre is much more stable when using method (a). Using method (b) the results show sudden variations with sometimes total disappearence of the haemagglutinating macroglobulin.The anti-RF serum produced neutralizes the RF completely in precipitation tests. The active principle of anti-RF is a fraction showing a sedimentation constant of about 7 S, i.e. exactly the same as that of the common yG. Comparing the 7 S, which has the property of neutralizing RF completely in unheated state, and the common yG (IgG) by immunoelectrophoresis, the first does

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Section: Resultsmentioning

confidence: 56%