Two Methods for Producing in Animals a Macroglobulin Similar to the Rheumatoid Factor

Svartz, Nanna; Hedman, Stig; Söderberg, Olof

doi:10.1111/j.0954-6820.1969.tb01451.x

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…As regards the third type of research touched upon at the beginning of this paper, it has concerned experimental investigations of the R F . The method for isolation of R F and the character of this hemagglutinating macroglobulin have been reported (22, 23,27). Only one point should be emphasized here.…”

Section: Resultsmentioning

confidence: 70%

“…The experimental work has mainly followed three lines:1. Studies of experimental arthritis (20,21,23,27).2. Bacteriological and immunological studies in patients suffering from R A and in experimentally produced arthritis (23, 27).…”

mentioning

confidence: 99%

“…2. Bacteriological and immunological studies in patients suffering from R A and in experimentally produced arthritis (23,27).…”

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confidence: 99%

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The Primary Cause of Rheumatoid Arthritis Is an Infection—the Infectious Agent Exists in Milk

Svartz¹

1972

Journal of Internal Medicine

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The theory of an infection as the primary cause of rheumatoid arthritis (RA) has been discussed periodically since more than four decades. The present author has made investigations on this problem over a period of many years. Several clinical symptoms, particularly as regards the findings in the joint fluid and in the granulation tissue, speak in favour of this opinion. Experimental research on animals with the aim of provoking an arthritis similar to RA has lent considerable support to the theory of an infection as the basis for RA. In my opinion the arthritis provoked by a type of Diplostreptococcus agalactiae belonging to the streptococci group B constitutes the condition of experimental arthritis most similar to human RA. In this respect it is important to consider that the experimental arthritis provoked by agalactiae is combined with the production of a hemagglutinating macroglobulin which, with our present methods, cannot be differentiated from the human rheumatoid factor (RF). We have long been engaged at our Institute in research into the source of infection. In our opinion it is a question of a milk infection and, as most milk consumed is pasteurized, the infection for the most part derives from pasteurized milk. In this connection it is important to emphasize that agalactiae cocci are resistant to the temperature used for pasteurizing milk. Furthermore, agalactiae can be cultivated from the nasopharynx in about 75–80% of RA cases. All RA patients investigated showed antibodies to agalactiae cultivated from the nasopharynx and from milk as well. Experimental arthritis and a rheumatoid‐factor‐like macroglobulin can be produced by the agalactiae cocci cultivated from pasteurized milk.

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Section: Resultsmentioning

confidence: 70%

mentioning

confidence: 99%