Macroglobulins in rheumatoid arthritis and allied diseases

Svartz, Nanna

doi:10.1016/0049-0172(71)90003-5

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…I would first select a more speculative but safer drug, either dapsone or salazopyrin; of the two, my current favourite for early RA is salazopyrin. First proposed 30 years ago for RA by Svartz,3 it has been little used but I have had some success with it.4 If I did not clearly benefit (with a reduction in ESR and serum CRP concentration after six weeks), I would switch to dapsone5 for similar reasons and for the same length of time. Failure with this drug too would be my signal to start gold or penicillamine.…”

Section: Second Stage Managementmentioning

confidence: 99%

If I had...Severe rheumatoid arthritis.

McConkey¹

1978

BMJ

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Section: Second Stage Managementmentioning

confidence: 99%

If I had...Severe rheumatoid arthritis.

McConkey¹

1978

BMJ

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“…We suggested that the relapse rates may be influenced by the different state of mucosal protective mechanisms at the time of healingthat is to say, that ulcer recurrences after cimetidine treatment can be promoted by the drug-induced alterations of gastric mucus. 3 Other explanations are possible. For instance, ultrastructural differences between the scar of a cimetidineand that of a colloidal bismuth-treated patient have been reported.…”

mentioning

confidence: 99%

Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?

Cohen¹

1982

BMJ

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Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta‐analysis

Morselli-Labate

Pezzilli

2009

J of Gastro and Hepatol

126

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High circulating serum immunoglobulin G4 (IgG4) levels have been proposed as a marker of autoimmune pancreatitis (AIP). The aim of the present study was to review the data existing in the English literature on the usefulness of the IgG4 serum levels in the diagnosis and follow up of patients with AIP. A total of 159 patients with AIP and 1099 controls were described in seven selected papers reporting the usefulness of serum IgG4 in diagnosing AIP. In total, 304 controls had pancreatic cancer, 96 had autoimmune diseases, and the remaining 699 had other conditions. The summary receiver-operating characteristic curve analysis was carried out by means of Meta-DiSc open-access software. Serum IgG4 showed good accuracy in distinguishing between AIP and the overall controls, pancreatic cancer and other autoimmune diseases (area under the curve [Ϯ SE]: 0.920 Ϯ 0.073, 0.914 Ϯ 0.191, and 0.949 Ϯ 0.024, respectively). The studies analyzed showed significantly heterogeneous specificity values in each of the three analyses performed. The analysis of the four studies comparing AIP and pancreatic cancers also showed significantly heterogeneous values of sensitivities and odds ratios. Regarding the usefulness of IgG4 as a marker of efficacy of steroid treatment, a decrease in the serum concentrations of IgG4 was found in the four available studies. The serum IgG4 subclass is a good marker of AIP, and its determination should be included in the diagnostic workup of this disease. However, the heterogeneity of the studies published until now means that more studies are necessary in order to better evaluate the true accuracy of IgG4 in discriminating AIP versus other autoimmune diseases.

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Macroglobulins in rheumatoid arthritis and allied diseases

Cited by 3 publications

References 27 publications

If I had...Severe rheumatoid arthritis.

If I had...Severe rheumatoid arthritis.

Does treatment with cimetidine extended beyond initial healing of duodenal ulcer reduce the subsequent relapse rate?

Usefulness of serum IgG4 in the diagnosis and follow up of autoimmune pancreatitis: A systematic literature review and meta‐analysis

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