Macromolecular Resonances

Possibility to Interfere with Coronavirus RNA Replication Analyzed by Resonant Recognition Model

“…Peak frequencies in such multiple cross-spectral function present common frequency components for all macromolecular sequences compared. The comprehensive analysis done so far confirms that all macromolecular sequences, with the common biological function and/or interaction, have common frequency component, which is specific feature for the observed biological function/interaction [13][14][15][16][17][18][19][20]. Thus, each specific macromolecular biological function/interaction within macromolecule is characterized by specific RRM frequency.…”

“…The Resonant Recognition Model (RRM) is biophysical, theoretical model that can analyze interactions between proteins and their targets, which could be other proteins, DNA, RNA, or small molecules. The RRM has been previously published in detail within number of publications [13][14][15][16][17][18][19][20]. The RRM model is based on the findings that certain periodicities (frequencies) within the distribution of energy of delocalized electrons along protein backbone are critical for protein biological function and/or interaction with their targets.…”

“…This means that the linear numerical signal representing the distribution of energies along the protein is transformed into the frequency domain and is characterized by number of different frequencies containing all information from the original signal. Comparing such spectra using cross-spectral function for proteins, which are sharing the same biological function/interaction, it has been shown that they share the same frequency within the spectrum of free energy distribution along the macromolecule [13][14][15][16][17][18][19][20]. Peak frequencies in such multiple cross-spectral function present common frequency components for all macromolecular sequences compared.…”

“…Each biological function is driven by proteins that selectively interact with other proteins, DNA/RNA regulatory segments or small molecules. Through extensive use of RRM model, it has been shown that proteins and their targets share the same matching RRM characteristic frequency [13][14][15][16][17][18][19][20][21][22][23][24]. The matching of periodicities within the distribution of energies of free electrons along the interacting proteins can be regarded as the resonant recognition and as such is highly selective.…”

“…Baring all this in mind, we propose that interfering with RNA replication regulation through RNA directed transcriptase and viral replicase or through 5' signal sequences within non-coding region of mRNA could be possible way of preventing RNA virus replication. Here, we have utilized our own biophysical Resonant Recognition Model (RRM) [13][14][15][16][17][18][19][20], which is capable of directly analyzing interaction between proteins and RNA [21][22], to analyze interaction between argonaute proteins, antibody IGHF3-53 and related RNA regulatory 5' signal sequences within non-coding region of mRNA with the aim to find out characteristic frequencies for initiation of viral replication. In addition, we have analyzed RNA replication through RNA directed transcriptase and viral replicase to identify characteristics of RNA viral replication by itself.…”