2010
DOI: 10.1016/j.cyto.2010.08.005
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Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood

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Cited by 73 publications
(62 citation statements)
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“…Similarly further reduction in serum cathepsin k was found in good responders [3.75(3-5.5)] versus poor responders [5.25(3.18-10.12)] which reflected that impact of treatment response was variable on patients of the same group. It may be due to other contributing poor factors as RF positivity, age, gender and disease duration, as three of them were male and all were seropositive and their disease duration range (12)(13)(14)(15)(16)(17)(18)(19)(20) years which declare that pathogenesis of RA may differ from a patient to another (disease severity), as well as effect of treatment varied also from one to another patient and this explanation was previously established by many authors [52].…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Similarly further reduction in serum cathepsin k was found in good responders [3.75(3-5.5)] versus poor responders [5.25(3.18-10.12)] which reflected that impact of treatment response was variable on patients of the same group. It may be due to other contributing poor factors as RF positivity, age, gender and disease duration, as three of them were male and all were seropositive and their disease duration range (12)(13)(14)(15)(16)(17)(18)(19)(20) years which declare that pathogenesis of RA may differ from a patient to another (disease severity), as well as effect of treatment varied also from one to another patient and this explanation was previously established by many authors [52].…”
Section: Discussionmentioning
confidence: 92%
“…association was found between IL-34 synovial tissue expression and synovitis severity in RA [11]. Eda et al, documented that IL-34 could increase IL-6 and chemokine levels in human whole blood [12]. It also could promote osteoclastogenesis in vitro [13].…”
Section: Introductionmentioning
confidence: 99%
“…3 -7 In addition to M-CSF, IL-34 has been shown to induce the release of chemokines such as interferon inducible protein-10, IL-8 and monocyte chemoattractant protein-1 in human whole blood, through binding to the colony stimulating factor 1 receptor. IL-34 also promotes increases in IL-1β, IL-6 and TNF-α levels 12 and stimulates monocyte viability, promoting the release of proinflammatory cytokines. 8 A further study has shown that the proinflammatory cytokines IL-1β, IL-6 and TNF-α can induce IL-34 in osteoblasts.…”
Section: Discussionmentioning
confidence: 99%
“…It is likely that IL-34 plays a role in inflammation, as it increases IL-6 and chemokine levels in human whole blood 11) . Interleukin-34 is also expressed in rheumatoid arthritis (RA) synovium, where it has been shown to be associated with severity of synovitis, and is elevated in serum and synovial fluid from RA patients 8) .…”
Section: Introductionmentioning
confidence: 99%