Macrophage content and colony-forming potential in mouse mammary carcinomas

Nash, Jennifer; Price, Janet E.; Tarin, David

doi:10.1038/bjc.1981.70

Cited by 19 publications

(11 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been suggested that the presence of macrophages may independently influence the outcome by affecting the metastatic potential of tumours (Lauder et al, 1977) and there is evidence from experimental animal tumours that this is so (Fidler & Poste, 1982;Eccles & Alexander, 1974; Wood & Gillespie, 1975). However, others have found otherwise; for example, in the case of murine mammary carcinoma (Nash et al, 1979). In vitro studies have shown a tumoricidal effect of human macrophages on a variety of human tumour lines including mammary carcinoma (Sone et al, 1984(Sone et al, , 1985.…”

mentioning

confidence: 93%

Macrophages in human breast disease: a quantitative immunohistochemical study

Kelly

Davison²,

Bliss³

et al. 1988

Br J Cancer

154

105

View full text Add to dashboard Cite

We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made of macrophage counts according to stage, grade and prognostic index of the malignant tumours. There was no correlation between macrophage numbers and any of these parameters in malignant breast tumours. We discuss the possible reasons why some earlier studies (using other markers such as lysozyme), have shown an apparently insignificant number of intratumoral macrophages. Images Figure 1 Figure 2

show abstract

mentioning

confidence: 93%

Macrophages in human breast disease: a quantitative immunohistochemical study

Kelly

Davison²,

Bliss³

et al. 1988

Br J Cancer

154

105

View full text Add to dashboard Cite

show abstract

“…Moreover, detailed studies on the activated macrophage content of spontaneously-occurring mammary carcinomas in mice showed no correlation with either spontaneous metastatic capability of the tumor nor with the capacity of its cells to colonize downstream organs after intravascular injection [57]. However, it should be mentioned that recently published data [58] have indicated that tumor associated macrophages (TAM) can diminish the efficacy of chemotherapeutic agents and that drugs blocking the cathepsin activity TAM improved the anti-tumor activity of the cytotoxic agents.…”

Section: Inflammation and Cancermentioning

confidence: 96%

Clinical and Biological Implications of the Tumor Microenvironment

Tarin¹

2012

Cancer Microenvironment

View full text Add to dashboard Cite

In normal tissues and organs, the activities of the constituent cells are strictly restricted to the tasks assigned to them during development. In addition they (with the exception of leukocytes) remain inflexibly confined to their territorial domains by regulatory interactions with their neighbors. This creates specialized local micro-environments in which structure and function are orderly, stable and tightly controlled by feed-back loops, within interacting regulatory networks. This system has considerable ability to adapt to changing conditions. In contrast, the microenvironment in regions where tumors are forming and expanding is characterized by progressive loss of specialized or differentiated cellular functions, disorderly molecular signals, degeneration of microscopical organ structure. This, coupled with the traffic of cells into and out of the tumor, often culminating in local invasion and metastasis to other organs. The nature of these disturbed molecular and cellular interactions is, by definition, highly unstable and increasingly unpredictable as time passes. It also varies between different tumors, sometimes even leading to regression. However, systematic analysis of this dysfunction in the tumor microcosm, using multiple modern research techniques, has revealed that all actively growing primary and secondary neoplasms share an absolute dependency upon support from adjacent non-neoplastic cells of the host. This support, in turn, continuously depends upon dynamic interplay between tumor and host cell populations, via signaling molecules and surface receptors in the tumor microenvironment. Such interplay determines the fate of the growing neoplasm. Such information, described and evaluated in this article, provides important new insights into the etiology of carcinogenesis and how tumor growth, invasion and metastasis might be therapeutically arrested. The facts and concepts assembled below, regarding the cancer microenvironment, demonstrate how modern molecular findings reveal the impact of the wide range of cancer diseases upon the internal cellular, tissue and organ environments of the whole individual and how this applies to designing new work to improve human cancer diagnosis and treatment. The article discusses several specific types of experimentally-induced and clinically common cancers to derive principles useful for interpreting events in the tumor microenvironment, which apply to cancers in general and especially to human malignant disease.

show abstract

“…Little, however, is known about the role of macrophages within metastases once the tumor has become established. The failure of the host to 85 inhibit metastatic growth may be related to qualitative (10,47) or quantitative (3) deficiencies in macrophages infiltrating metastases. Conceivably such a deficiency could allow metastases to circumvent host defense mechanisms and grow progressively.…”

Section: Discussionmentioning

confidence: 99%

“…Still other studies have reported that metastases contain fewer macrophages than the primary tumors from which they originate (3). Conceivably, a deficiency in macrophage infiltration of metastases could allow these tumors to circumvent host defense mechanisms and grow progressively, although, again, these generalizations have not been confirmed (10,14,15). Thus, the role of macrophages in control of metastatic growth is far from clear.…”

Section: Introductionmentioning

confidence: 99%

Macrophages in cancer metastases and their relevance to metastatic growth

Key

1983

Cancer Metast Rev

View full text Add to dashboard Cite

The dissemination of malignant cells throughout the body to form secondary growths is a highly complex process dependent upon both host and tumor cell properties. One potential defensive system which could influence the outcome of metastasis is the mononuclear phagocyte system. Although macrophages have been observed in essentially all primary and metastatic tumors examined regardless of histologic type or anatomic location, the biological significance of these observations is far from clear. What is clear, however, is that in most cases the effects of macrophages on tumor cells are not sufficient to alter progressive growth. Therefore, the presence of macrophages within metastases does not necessarily signify a protective host defensive response. On the other hand, macrophage-induced regression of established metastases can occur in vivo under certain conditions in which tumor-bearing mice are treated systemically with macrophage-activating agents. When mice bearing metastases are treated with macrophage-activating agents contained within liposomes, metastasis-associated macrophages are activated to the tumoricidal state and the metastatic lesions are simultaneously eradicated. Such a process of macrophage activation may have implications in determining successful approaches to the therapy of disseminated cancer.

show abstract

Macrophage content and colony-forming potential in mouse mammary carcinomas

Cited by 19 publications

References 16 publications

Macrophages in human breast disease: a quantitative immunohistochemical study

Macrophages in human breast disease: a quantitative immunohistochemical study

Clinical and Biological Implications of the Tumor Microenvironment

Macrophages in cancer metastases and their relevance to metastatic growth

Contact Info

Product

Resources

About