Macrophage-Derived Extracellular Vesicle Promotes Hair Growth

Rajendran, Ramya Lakshmi; Gangadaran, Prakash; Seo, Changhoon; Kwack, Mi Hee; Oh, Ji Min; Lee, Ho Won; Gopal, Arunnehru; Sung, Young Kwan; Jeong, Shin Young; Lee, Sang‐Woo; Lee, Jaetae; Ahn, Byeong‐Cheol

doi:10.3390/cells9040856

Cited by 70 publications

(66 citation statements)

References 72 publications

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“…Moreover, intradermal injection of Wnt3a- and Wnt7b-enriched MAC-EV in male balb/C mice enhanced HF growth in vivo. Moreover, treatment with MAC-EV increased the size of hair shaft in human HF in a short time period [ 48 ]. Conversely, Wnt5a, a non-canonical Wnt expressed in bulge and secondary hair germ cells at telogen stage, antagonizes the function of canonical Wnts.…”

Section: Role Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

140

105

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

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Section: Role Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

140

105

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“…It was also shown that macrophage-EVs were enriched in the active accessible pool of cholesterol, which increased the efficiency of cholesterol transfer to high-density lipoprotein, thus lowering the cholesterol level 63 . A recent study reported that Wnt proteins, such as Wnt3a and Wnt7b, were enriched in macrophage-EVs, thus activating the Wnt/β-catenin signaling pathway to enhance hair follicle growth in vivo and in vitro 64 .…”

Section: Characteristics and Functions Of Evs From Cells Associated Wmentioning

confidence: 99%

Extracellular vesicles in Inflammatory Skin Disorders: from Pathophysiology to Treatment

Shao¹,

Fang²,

Li³

et al. 2020

Theranostics

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Extracellular vesicles (EVs), naturally secreted by almost all known cell types into extracellular space, can transfer their bioactive cargos of nucleic acids and proteins to recipient cells, mediating cell-cell communication. Thus, they participate in many pathogenic processes including immune regulation, cell proliferation and differentiation, cell death, angiogenesis, among others. Cumulative evidence has shown the important regulatory effects of EVs on the initiation and progression of inflammation, autoimmunity, and cancer. In dermatology, recent studies indicate that EVs play key immunomodulatory roles in inflammatory skin disorders, including psoriasis, atopic dermatitis, lichen planus, bullous pemphigoid, systemic lupus erythematosus, and wound healing. Importantly, EVs can be used as biomarkers of pathophysiological states and/or therapeutic agents, both as carriers of drugs or even as a drug by themselves. In this review, we will summarize current research advances of EVs from different cells and their implications in inflammatory skin disorders, and further discuss their future applications, updated techniques, and challenges in clinical translational medicine.

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“…Moreover, experiments in the culture of mouse macrophages showed that their apoptosis occurs in parallel with the release of Wnts and that apoptotic macrophages stimulate the expression of Wnts by neighboring macrophages (Castellana et al, 2014). Interestingly, macrophages seem to produce extracellular vesicles containing Wnt3a and Wnt7b (Rajendran et al, 2020). Thus, the apoptotic reduction of macrophages during TAT is associated with the activation of the Wnt/β-catenin cascade (Castellana et al, 2014).…”

Section: The Hf Cycle and Immunity In Physiological And Injury-inducementioning

confidence: 99%