Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles

Raynal, Isabelle; Prigent, Philippe; Peyramaure, Sophie; Najid, A; Rebuzzi, Cécile; Corot, Claire

doi:10.1097/01.rli.0000101027.57021.28

Cited by 372 publications

(131 citation statements)

References 32 publications

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“…Ferumoxtran-10 (Sinerem, Guerbet, Aulnay-sous-Bois, France, and Combidex, Advanced Magnetics, Cambridge, Mass., USA) is a dextran-coated superparamagnetic iron oxide nanoparticle which is undergoing clinical phase III trials for the diagnosis of lymph node metastases [12]. In addition, it is also an appropriate MRI marker for the diagnosis of degenerative and inflammatory disorders, e.g.…”

Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging of Ruptured Plaques in the Rabbit with Ultrasmall Superparamagnetic Particles of Iron Oxide

Durand

Raynaud²,

Bruneval³

et al. 2007

J Vasc Res

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Background: Magnetic resonance imaging (MRI) enhanced with ultrasmall superparamagnetic particles of iron oxide (USPIO) has previously been evaluated in hyperlipidemic rabbits. The aim of this study was therefore to compare USPIO in ruptured and non-ruptured arteries in an atherosclerotic rabbit model. Methods: Atherosclerotic-like lesions were induced by the combination of endothelial abrasion and high-cholesterol diet in iliac rabbit arteries (n = 16). Rupture of atherosclerotic lesions was realized by oversized balloon angioplasty in one iliac artery, whereas the contralateral artery was used as control. USPIO (ferumoxtran-10: 1 mmol Fe/kg) was administered immediately (n = 10) or 28 days (n = 6) after injury. MRI and histological analysis were performed 7 and 35 days after injury and in control arteries. Results: In vivo MRI analysis showed extended susceptibility artifact with transluminal signal loss in all ruptured arteries 7 days after injury. In contrast, hyposignal was reduced 35 days following injury (i.e. after healing), and absent in non-ruptured arteries. Similarly, histological analysis of iron uptake was significantly increased 7 days after injury compared to healed-ruptured and control arteries. Conclusions: Accumulation ofUSPIO is significantly increased in ruptured as compared to non-ruptured arteries in the atherosclerotic rabbit model.

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Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging of Ruptured Plaques in the Rabbit with Ultrasmall Superparamagnetic Particles of Iron Oxide

Durand

Raynaud²,

Bruneval³

et al. 2007

J Vasc Res

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“…Furthermore, the iron contained in ferumoxtran-10 was incorporated into the body's iron stock where increasingly found in the red blood cells as a constituent of hemoglobin structure [281]. As a result, the dextran-coated SPIONs did not show any chronic toxicity and their uptake by macrophages was not associated with cell activation [282][283][284].…”

Section: Biological Response Of Spionsmentioning

confidence: 99%

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Mahmoudi

Simchi

Imani

2010

JICS

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Superparamagnetic iron oxide nanoparticles (SPIONs) are promising materials for various biomedical applications including targeted drug delivery and imaging, hyperthermia, magneto-transfections, gene therapy, stem cell tracking, molecular/cellular tracking, magnetic separation technologies (e.g. rapid DNA sequencing), and detection of liver and lymph node metastases. The most recent applications for SPIONs for early detection of inflammatory, cancer, diabetes and atherosclerosis have also increased their popularity in academia. In order to increase the efficacy of SPIONs in the desired applications, especial surface coating/characteristics are required. The aim of this article is to review the surface properties of magnetic nanoparticles upon synthesis and the surface engineering by different coatings. The biological aspects, cytotoxicity, and health risks are addressed. Special emphasis is given to organic and inorganic-based coatings due to their determinant role in biocompatibility or toxicity of the final particles.

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“…NP uptake by leukocytes such as neutrophils and monocytes has been reported to occur mainly through the mechanism of phagocytosis, and to a small measure by pinocytosis. 22,23 On the contrary, lymphocytes do not possess the intrinsic ability of phagocytosis. 24 Lymphocytes internalize NPs by the mechanism of endocytosis.…”

Section: Discussionmentioning

confidence: 99%

Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes

Easo

Mohanan

2016

Biointerphases

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Iron oxide nanoparticles present an attractive choice for carcinogenic cell destruction via hyperthermia treatment due to its small size and magnetic susceptibility. Dextran stabilized iron oxide nanoparticles (DIONPs) synthesized and characterized for this purpose were used to evaluate its effect on cellular uptake, cytotoxicity, and oxidative stress response in human peripheral blood lymphocytes. In the absence of efficient internalization and perceptible apoptosis, DIONPs were still capable of inducing significant levels of reactive oxygen species formation shortly after exposure. Although these particles did not cause any genotoxic effect, they enhanced the expression of a few relevant oxidative stress and antioxidant defense related genes, accompanied by an increase in the glutathione peroxidase activity. These results indicate that under the tested conditions, DIONPs induced only minimal levels of oxidative stress in lymphocytes. Understanding the biological interaction of DIONPs, the consequences as well as the associated mechanisms in vitro, together with information obtained from systemic studies, could be expected to advance the use of these particles for further clinical trials.

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Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles

Cited by 372 publications

References 32 publications

Magnetic Resonance Imaging of Ruptured Plaques in the Rabbit with Ultrasmall Superparamagnetic Particles of Iron Oxide

Magnetic Resonance Imaging of Ruptured Plaques in the Rabbit with Ultrasmall Superparamagnetic Particles of Iron Oxide

Recent advances in surface engineering of superparamagnetic iron oxide nanoparticles for biomedical applications

Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes

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