Macrophage immunomodulatory activity of polysaccharides isolated from Glycyrrhiza uralensis fish

Cheng, Anwei; Wan, Fachun; Wang, Jiaqi; Jin, Zhengyu; Xu, Xueming

doi:10.1016/j.intimp.2007.10.006

Cited by 157 publications

(88 citation statements)

References 33 publications

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“…Moreover, MPH may play a positive role in the wound healing process due to its polysaccharide structure, since MPH is a plantbased polysaccharide. Many studies have shown that polysaccharides accelerate the healing process primarily by macrophage activation (13)(14)(15)(16)(17)(18)(19)(20) as well as by fibroblast stimulation (25)(26)(27) and by T-cell stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…MPH particles form a gelled matrix by concentrating blood solids such as platelets, red blood cells, and blood proteins such as, albumin, thrombin and fibrinogen; thus, are used to achieve hemostasis in case of persistent bleeding (11,12). Also, many studies have shown that polysaccharides accelerate and enhance wound healing via various mechanisms, primarily by increasing the activity of macrophages (13)(14)(15)(16)(17)(18)(19)(20). It can be presumed that the MPH can reduce seroma formation by virtue of these characteristics, by preventing the mechanisms causing seroma formation.…”

Section: Introductionmentioning

confidence: 99%

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Microporous Polysaccharide Hemospheres and Seroma Formation After Mastectomy and Axillary Dissection in Rats

et al. 2012

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Objective: Seroma is the most common complication after breast surgery. Several methods have been proposed to prevent seroma, but none of these provided a significant effect. A prolonged wound healing process is the most important cause of seroma. Microporous polysaccharide hemospheres (MPH) are used to achieve hemostasis. They may also accelerate wound healing. In this study, the effects of MPH on seroma formation were investigated.Material and Methods: Female Wistar rats weighing between 200 g and 250 g were used. There were eight rats in each of the control and study groups. Right breast mastectomy and axillary dissection were performed in all rats. While no application was performed after the operation in the control group, MPH was locally applied to the surgical site in the study group. Ten days after the operation, seroma fluid was aspirated and the total volume was recorded. The aspirates were analyzed and tissue samples were obtained from the surgical site.Results: Seroma was significantly lower in the study group (p=0.001). The mean albumin and lactate dehydrogenase levels were significantly lower in the study group (p=0.003). Pathological examination revealed that increase in fibrous tissue was significantly greater in the control group (p=0.032).Conclusion: MPH may reduce seroma after mastectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microporous Polysaccharide Hemospheres and Seroma Formation After Mastectomy and Axillary Dissection in Rats

et al. 2012

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“…It is felt that an extract of G. uralensis may be effective in the treatment of peptic ulcer disease (Aly et al, 2005;Nassiri Asl & Hosseinzadeh, 2008). Recently, antiinflammatory, antioxidative , immunomodulatory, and other biological activities of this plant were reported (Cheng et al, 2008;. Anti-H. pylori activities of chemical constituents of the different Glycyrrhiza species, and methanol extract and flavonoids of G. uralensis, were studied.…”

Section: Glycyrrhiza Uralensismentioning

confidence: 99%

Medicinal plants in the treatment ofHelicobacter pyloriinfections

Safavi

Shams-Ardakani

Foroumadi

2014

Pharmaceutical Biology

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Context: Helicobacter pylori is a small, spiral, Gram-negative bacillus that plays a role in the pathogenesis of a number of diseases ranging from asymptomatic gastritis to gastric cancer. Schedule compliance, antibiotic drug resistance, and side-effects of triple or quadruple therapy have led to research for novel candidates from plants.Objective: The purpose of this paper is to review the most potent medicinal plants of recently published literature with anti-H. pylori activity. For centuries, herbals have been used by traditional healers around the world to treat various gastrointestinal tract disorders such as dyspepsia, gastritis, and peptic ulcer disease. The mechanism of action by which these botanicals exert their therapeutic properties has not been completely and clearly elucidated. Anti-H. pylori properties may be one of the possible mechanisms by which gastroprotective herbs treat gastrointestinal tract disorders. Materials and methods: Electronic databases such as PubMed, Google scholar, EBSCO, and local databases were explored for medicinal plants with anti-H. pylori properties between 1984 and 2013 using key words ''medicinal plants'' and ''Helicobacter pylori'' or ''anti-Helicobacter pylori''. Results: A total of 43 medicinal plant species belonging to 27 families including Amaryllidaceae,

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“…[69] The immunmodulatory effect of polysaccharides from green seaweeds is mainly based on macrophage modulation. [70] The polysaccharide isolated from Ganoderma atrum proved macrophage immunomodulatory activity [37] , water-soluble polysaccharide obtained from Acorus calamus activates macrophages and stimulates Th1 response [71] , the polysaccharide isolated from Opuntia polyacantha [72] and Glycyrrhiza uralensis [73] had…”

Section: Determination Of Tnf-α Levelsmentioning

confidence: 99%