Macrophage Inflammatory Protein-1 Beta (MIP-1&amp;lt;i&amp;gt;β&amp;lt;/i&amp;gt;) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis&amp;lt;br&amp;gt; —MIP, MPV and PDW in SBP

Khorshed, Soha E; Ibraheem, Hoda A.; Awad, Shereen M

doi:10.4236/ojgas.2015.57016

Cited by 9 publications

(13 citation statements)

References 25 publications

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“…As regards acute inflammatory marker C reactive protein (CRP) in serum, the current study showed a significant increase in SBP versus none SBP group. This result matched with previous results 7,9,[12][13][14][15] .…”

Section: Discussionsupporting

confidence: 93%

“…In this study, there was a positive correlation with total leucocyte count, serum CRP and ascitic fluid LDH in the SBP group. However, Khorshed et al found a positive correlation between MIP-1β, mean platelet volume, platelet distribution width, and PMN in ascites 7 . The current study revealed a significant decrease in ascitic fluid MIP-1β after 48 hours of proper intravenous antibiotic administration.…”

Section: Discussionmentioning

confidence: 96%

“…Lesinska et al found that, at cut-off value 69.4pg/ml, MIP-1β had 80% sensitivity and 72.7% specificity for prediction of SBP with PPV (57.1%) and N PV (88.9%) 6. Another study reported that, ascitic fluid MIP-1β with cut off value 121.9 pg/ml (76.1% sensitivity, 100% specificity, PPV 100% and NPV 80%, AUC=0.881) 7 . As regards acute inflammatory marker C reactive protein (CRP) in serum, the current study showed a significant increase in SBP versus none SBP group.…”

Section: Discussionmentioning

confidence: 99%

“…SBP is a serious cause of morbidity as well as mortality in patients with cirrhosis and ascites. Diagnosis of SBP should be early and accurate to avoid its complications 7 . The diagnosis of SBP is mainly dependent on a manual count of the ascitic fluid count of PMN which, is operatordependent and the false-negative result may occur due to destruction of PMN during transport.…”

Section: Discussionmentioning

confidence: 99%

“…MIP-1β known also as CCL4 is an active protein, which is produced by macrophages. MIP-1β acts as a mitogen-inducible cytokine which stimulates inflammatory responses 7 . In the present study, ascitic fluid MIP-1β was statistically significantly higher in the SBP group in comparison to non-SBP ascitic cirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

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Macrophage Inflammatory Protein Type 1 Beta as a Novel Diagnostic Marker for Diagnosis of Spontaneous Bacterial Peritonitis

Mahmoud

El-gharabawy

Elhelaly

et al. 2021

Medical Journal of Viral Hepatitis

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Background: Spontaneous bacterial peritonitis (SBP) is a severe complication of cirrhotic ascites. SBP diagnosis is based on the count of ascitic fluid neutrophils (>250/mm 3). This procedure is an invasive maneuver with many complications. This study aimed to find a sensitive diagnostic tool for SBP by examining ascitic fluid Macrophage Inflammatory Protein type 1 beta (MIP-1β) as a rapid bedside test for diagnosis of SBP. Materials and methods: The study included 53 cirrhotic ascitic patients (33 with and 20 without SBP). Patients were subjected to thorough medical history taking, clinical examination, and laboratory investigation. Two ascitic fluid samples were taken, the first at admission time for cell count and culture, and the second sample was taken 48 hours after treatment in patients with SBP. Ascitic MIP-1β was measured using ELISA technique at admission in both groups and 48 hours after treatment in the SBP group. Results: Ascitic MIP-1β and CRP levels were significantly higher in the SBP group versus non-SBP patients. There was a significant positive correlation between ascitic fluid MIP-1β and WBCs and serum CRP. Ascitic fluid MIP-1β at a cutoff value ≥ of 31.95 pg/ml had 79% sensitivity and 75% specificity for the diagnosis of SBP. Combined ascetic fluid MIP-1β at the cutoff value ≥31.95 pg/ml and CRP in serum at a cutoff value ≥of 36 mg/L had 61% sensitivity and 100% specificity. There was a significant decrease of both, ascitic MIP-1β and ascetic fluid PMN after treatment of SBP. Conclusions: Ascitic fluid MIP-1β is highly sensitive and specific in the diagnosis of SBP-especially when combined with CRP. Patients and methods This is a prospective case-control study that included 53 cirrhotic patients with ascites. The patients were classified into two groups; Group (1) included 33 patients with ascitic fluid PMN > 250/mm 3 (SBP group), and group (2) included 20 patients with an ascitic neutrophil count below 250 cells/mm 3 and-ve culture (Non-SBP group). Our patients were admitted to Specialized Medical Hospital, Mansoura University from January 2016 till the end of January 2017. All patients were above 18 years. Patients who had hepatocellular carcinoma, extrahepatic malignancy, recent abdominal surgery, hemoperitoneum, recent antibiotic therapy (within 48 hours before admission) chronic dialysis, acute pancreatitis, autoimmune diseases, organ transplant, HIV infections, or having other infections were excluded from the study. All patients underwent a thorough clinical evaluation (history taking, general and systemic examination). Laboratory tests, including complete CBC, serum creatinine, liver function tests, serum CRP, and urine analysis, radiological investigations (abdominal ultrasound, chest-X ray, and Triphasic CT when indicated) were done. Ascitic fluid analysis and culture were done at index

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Macrophage Inflammatory Protein Type 1 Beta as a Novel Diagnostic Marker for Diagnosis of Spontaneous Bacterial Peritonitis

Mahmoud

El-gharabawy

Elhelaly

et al. 2021

Medical Journal of Viral Hepatitis

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Neutrophil to Lymphocyte Ratio and Spontaneous Bacterial Peritonitis among Cirrhotic Patients: A Systematic Review and Meta-analysis

Seyedi¹,

Nabipoorashrafi²,

Hernandez

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Background. The goal of this systematic review and meta-analysis was analyzing published studies on the role of neutrophil to lymphocyte ratio (NLR) in infection and spatially spontaneous bacterial peritonitis (SBP) among cirrhotic patients. Methods. PubMed, Web of Science, and Scopus were searched until May 24, 2022. The Newcastle–Ottawa scale was used for quality assessment. Results. Of 14 studies included in our study, six studies were on infection with 2786 hospitalized cirrhotic patients, of whom 934 developed an infection. Other studies were on SBP with 1573 cirrhotic patients with ascites, of whom 557 developed SBP. The pooled results showed that there was no difference in NLR levels between hospitalized cirrhotic patients who developed infection compared to those who did not (random-effects model: SMD = 0.63, 95% CI = −0.01–1.27, p = 0.054 ). However, cirrhotic patients with ascites who developed SBP had elevated levels of NLR compared to those who did not (random-effects model: SMD = 1.05, 95% CI = 0.52–1.57, p < 0.001 ). This difference remained significant in prospective studies (SMD = 0.94, 95% CI = 0.51–1.38, p < 0.001 ) but not in retrospective studies (SMD = 1.37, 95% CI = −0.56–3.29, p = 0.165 ), in the subgroup analysis according to the study design. The pooled sensitivity of NLR was 92.07% (95% CI = 74.85%–97.84%) and the pooled specificity was 72.58% (95% CI = 57.72%–83.69%). The pooled positive likelihood ratio, negative likelihood ratio, DOR of NLR were 3.35(95%CI = 2.06–5.46), 0.10 (95%CI = 0.03–0.38), and 30.78 (95%CI = 7.01–135.04), respectively. Conclusion. Our results support NLR to be a valid biomarker that can be readily integrated into clinical settings to help in the prevention and prediction of SBP among cirrhotic patients.

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Validation of the diagnostic accuracy of neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) in cirrhotic patients with spontaneous bacterial peritonitis

Abudeif

El-Badry

Ahmed

2023

Egypt Liver Journal

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Background Spontaneous bacterial peritonitis (SBP) is a significant complication among cirrhotic patients with ascites and is associated with high mortality. Early diagnosis and treatment of SBP are crucial, as they are associated with better outcomes and lower mortality. The neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) are routine, inexpensive, easily measured markers readily obtained from a complete blood count (CBC). Several studies have addressed the diagnostic role of NLR and MPV in patients with SBP but with different cutoff values, sensitivity, and specificity. Therefore, we conducted this study to validate the clinical utility of NLR and MPV in diagnosing SBP. Methods This study included 332 cirrhotic patients with ascites who were admitted to Sohag University Hospitals in Egypt between April 2020 and April 2022. Of these patients, 117 had SBP, and 215 did not. Both NLR and MPV were measured in all patients, and the ability of NLR and MPV to diagnose SBP was assessed using the receiver operator characteristic (ROC) curve analysis. Results NLR and MPV were significantly elevated in patients with SBP compared to those without SBP (P < 0.001). At a cutoff value of 5.6, the sensitivity and specificity of the NLR in detecting SBP were 78% and 81%, respectively. In contrast, MPV, at a cutoff value of 8.8 fL, had a sensitivity of 62% and a specificity of 63%. The combination of NLR and MPV did not provide significant additional diagnostic value beyond only using NLR. Conclusion Although NLR and MPV allow the detection of SBP, the NLR has higher clinical utility and is superior to MPV in diagnosing SBP.

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Macrophage Inflammatory Protein-1 Beta (MIP-1<i>β</i>) and Platelet Indices as Predictors of Spontaneous Bacterial Peritonitis<br> —MIP, MPV and PDW in SBP

Cited by 9 publications

References 25 publications

Macrophage Inflammatory Protein Type 1 Beta as a Novel Diagnostic Marker for Diagnosis of Spontaneous Bacterial Peritonitis

Macrophage Inflammatory Protein Type 1 Beta as a Novel Diagnostic Marker for Diagnosis of Spontaneous Bacterial Peritonitis

Neutrophil to Lymphocyte Ratio and Spontaneous Bacterial Peritonitis among Cirrhotic Patients: A Systematic Review and Meta-analysis

Validation of the diagnostic accuracy of neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) in cirrhotic patients with spontaneous bacterial peritonitis

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