Macrophage Inflammatory Protein-1 Production and Eosinophil Infiltration in Chronic Rhinosinusitis With Nasal Polyps

Abstract

MIP-1α may play a role in eosinophil recruitment in NP. Our results suggest that the measurement of MIP-1α in nasal secretions could be useful in evaluating the degree of eosinophil inflammation and severity of disease in nonallergic patients.

Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins

“…41 Eosinophil infiltration in CRSwNP involves a number of chemokines. 42 In our study, there was no correlation between ␣-defensins and blood eosinophil levels in all the groups, but a strong positive correlation was observed between NS ␣-defensins and NS IL-5 levels in the CRSwNP group. Eosinophils can constitutively express ␣-defensins and release them after activation, 43 which led us to hypothesize that the highest levels of ␣-defensins in CRSwNP may be contributed by eosinophilic granulocytes.…”

Nonselective chemokine levels in nasal secretions of patients with perennial nonallergic and allergic rhinitis

“…It has been shown that contents of nasal fluid reflect the inflammatory status of the nasal mucosa and parallel the evolution of mucosal disease . Our previous study demonstrated that chemokine levels in nasal secretions correlate well with clinical parameters and cytological findings in patients with chronic polypous rhinosinusitis . Cytological exploration of the nasal mucosa is a helpful path to better knowledge of pathophysiology of chronic inflammatory diseases and in correct differential diagnosis …”

A panel of clinical and biological markers predict difficult‐to‐treat chronic rhinosinusitis

“…8 MIP-1β is a chemokine for CCR5-expressing cells, including natural killer cells, monocytes, and eosinophils, and may participate in the prolongation of chronic inflammation in CRS. 9 The strengths and limitations of our current study are discussed in Data S1.…”