Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: Molecular insights and therapeutic prospects

Bi, Zhiguo; Cai, Yimeng; Shi, Xiaotong; Chen, Jintian; Li, Dongsong; Zhang, Peibiao; Liu, Jianguo

doi:10.1016/j.cej.2024.150631

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.150631

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Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: Molecular insights and therapeutic prospects

Zhiguo Bi,

Yimeng Cai,

Xiaotong Shi

et al.

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Cited by 7 publications

References 255 publications

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, and congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these severe bone defects, without incurring prevalent complications associated with conventional autologous or allogeneic bone grafts. 3D printing technology enables control over architectural structures at multiple length scales and has been extensively employed to process biomimetic scaffolds for BTE. In contrast to inert and functional bone grafts, next‐generation smart scaffolds possess a remarkable ability to mimic the dynamic nature of native extracellular matrix (ECM), thereby facilitating bone repair and regeneration. Additionally, they can generate tailored and controllable therapeutic effects, such as antibacterial or antitumor properties, in response to exogenous and/or endogenous stimuli. This review provides a comprehensive assessment of the progress of 3D‐printed smart scaffolds for BTE applications. It begins with an introduction to bone physiology, followed by an overview of 3D printing technologies utilized for smart scaffolds. Notable advances in various stimuli‐responsive strategies, therapeutic efficacy, and applications of 3D‐printed smart scaffolds are discussed. Finally, the review highlights the existing challenges in the development and clinical implementation of smart scaffolds, as well as emerging technologies in this field.

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Yuan,

Zhu,

Yang

et al. 2024

Advanced Materials

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A Single‐Cell RNA Sequencing Guided Multienzymatic Hydrogel Design for Self‐Regenerative Repair in Diabetic Mandibular Defects

Lin,

Qian,

Liu

et al. 2024

Advanced Materials

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Conventional bone tissue engineering materials struggle to reinstate physiological bone remodeling in a diabetic context, primarily due to the compromised repolarization of proinflammatory macrophages to anti‐inflammatory macrophages. Here, leveraging single‐cell RNA sequencing (scRNA‐seq) technology, the pivotal role of nitric oxide (NO) and reactive oxygen species (ROS) is unveiled in impeding macrophage repolarization during physiological bone remodeling amidst diabetes. Guided by scRNA‐seq analysis, we engineer a multienzymatic bone tissue engineering hydrogel scaffold (MEBTHS) composed is engineered of methylpropenylated gelatin hydrogel integrated with ruthenium nanozymes, possessing both Ru0 and Ru4+ components. This design facilitates efficient NO elimination via Ru0 while simultaneously exhibiting ROS scavenging properties through Ru4+. Consequently, MEBTHS orchestrates macrophage reprogramming by neutralizing ROS and reversing NO‐mediated mitochondrial metabolism, thereby rejuvenating bone marrow‐derived mesenchymal stem cells and endothelial cells within diabetic mandibular defects, producing newly formed bone with quality comparable to that of normal bone. The scRNA‐seq guided multienzymatic hydrogel design fosters the restoration of self‐regenerative repair, marking a significant advancement in bone tissue engineering.

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Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Shariati,

Bedar,

Huang

et al. 2024

Advanced Therapeutics

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Tissue regeneration involves dynamic dialogue between and among different cells and their surrounding matrices. Bone regeneration is specifically governed by reciprocity between osteoblasts and osteoclasts within the bone microenvironment. Osteoclast‐directed resorption and osteoblast‐directed formation of bone are essential to bone remodeling, and the crosstalk between these cells is vital to curating a sequence of events that culminate in the creation of bone tissue. Among bone biomaterial strategies, many have investigated the use of different material cues to direct the development and activity of osteoblasts. However, less attention has been given to exploring features that similarly target osteoclast formation and activity, with even fewer strategies demonstrating or integrating biomaterial‐directed modulation of osteoblast‐osteoclast coupling. This review aims to describe various biomaterial cues demonstrated to influence osteoclastogenesis and osteoclast function, emphasizing those that enhance a material construct's ability to achieve bone healing and regeneration. Additionally discussed are approaches that influence the communication between osteoclasts and osteoblasts, particularly in a manner that takes advantage of their coupling. Deepening the understanding of how biomaterial cues may dictate osteoclast differentiation, function, and influence on the microenvironment may enable the realization of bone‐replacement interventions with enhanced integrative and regenerative capacities.

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Macrophage-mediated immunomodulation in biomaterial-assisted bone repair: Molecular insights and therapeutic prospects

Cited by 7 publications

References 255 publications

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

A Single‐Cell RNA Sequencing Guided Multienzymatic Hydrogel Design for Self‐Regenerative Repair in Diabetic Mandibular Defects

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

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