Macrophage migration inhibitory factor gene polymorphisms (SNP ‐173 G&gt;C and STR‐794 CATT5‐8) confer risk of plaque psoriasis: A case–control study

Hernández‐Bello, Jorge; Rodríguez-Puente, Miroslaba; Gutiérrez–Cuevas, Jorge; García‐Arellano, Samuel; Muñoz‐Valle, José Francisco; Fafutis‐Morris, Mary; Villanueva-Quintero, Delfina Guadalupe; Alvarado-Navarro, Anabell

doi:10.1002/jcla.23999

Cited by 6 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MIF is a key proinflammatory cytokine that plays a role in inflammation, autoimmune, metabolic diseases, and cancer. 27 In recent years, the MIF rs755622(−173G/C) polymorphism has been shown to be associated with the pathogenesis and progression of autoimmune diseases, such as rheumatoid arthritis (RA), 28 psoriasis, 29 systemic sclerosis (SSc), 30 and systemic lupus (SLE). 31 A study in a population of western Mexicans confirmed a significant association between MIF gene polymorphisms (−794CATT5-8 and −173G/C) and NSV.…”

Section: Discussionmentioning

confidence: 99%

Association Among MIF, IFIH1, and IL6 Gene Polymorphisms and Non-Segmental Vitiligo in a Chinese Han Population

Wang¹,

Min²,

Lin³

et al. 2022

CCID

View full text Add to dashboard Cite

Objective The aim of the present study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the macrophage migration inhibiting factor ( MIF ), interferon-induced Helicase C domain 1 ( IFIH1 ), interleukin-6 ( IL6 ) genes, circulating levels with non-segmental vitiligo (NSV) susceptibility in the Chinese population, and to analyze the relationships between gene polymorphisms and clinical characteristics of vitiligo. Methods In this study, genotyping was conducted in 155 patients with NSV and 117 unaffected controls using polymerase chain reaction and snapshot technique. Serum concentrations were determined by ELISA kit. Results There were strong associations between IFIH1 H843R and IL6 -572G/C polymorphisms and NSV susceptibility ( p = 0.013; p = 0.009). In contrast to previous studies, we found no significant difference in the MIF -173G/C polymorphism between the two groups. In addition, the frequency of allelic distribution for MIF -173G/C in patients with active NSV was significantly higher than stable NSV ( p = 0.011), and IFIH1 H843R with early-onset (≤ 20), active or family history of NSV was significantly higher than late-onset (> 20), stable or no family history of NSV ( p = 0.033; p = 0.045; p = 0.039). Serum concentrations of MIF were higher in patients with active NSV, serum IFIH1 and IL6 concentrations were related to the presence of polymorphisms in patients with NSV ( p = 0.009; p = 0.011). Conclusion Our results suggested that IFIH1 H843R and IL6 -572G/C gene polymorphisms and expression levels are obviously correlated with the onset of NSV. MIF -173G/C allele and serum concentrations may be associated with active NSV, and IFIH1 H843R allele may be associated with youth, active or family history of NSV.

show abstract