Macrophage migration-inhibitory factor is elevated in pregnant women with gestational diabetes mellitus

Yılmaz, Özgür; Küçük, Mert; Kebapçılar, Levent; Altındağ, Tamer; Yüksel, Arif; Yuvanc, Huseyin Oguz; Dal, Tuba; Savran, Yusuf

doi:10.3109/09513590.2011.588757

Cited by 16 publications

(13 citation statements)

References 35 publications

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“…MIF has also been implicated in gestational diabetes, with higher serum MIF in women with gestational diabetes (11.2 ± 0.75 ng/ml) than in healthy pregnant controls (5.31 ± 0.64 ng/ml) (54). Furthermore, associations between MIF genotype Rs1007888GG and gestational diabetes as well as pre-pregnancy obesity and family history of diabetes have been reported (55).…”

Section: Human Studiesmentioning

confidence: 99%

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Morrison

Kleemann

2015

Front. Immunol.

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Obesity is associated with a chronic low-grade inflammatory state that drives the development of obesity-related co-morbidities such as insulin resistance/type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This metabolic inflammation is thought to originate in the adipose tissue, which becomes inflamed and insulin resistant when it is no longer able to expand in response to excess caloric and nutrient intake. The production of inflammatory mediators by dysfunctional adipose tissue is thought to drive the development of more complex forms of disease such as type 2 diabetes and NAFLD. An important factor that may contribute to metabolic inflammation is the cytokine macrophage migration inhibitory factor (MIF). Increasing evidence suggests that MIF is released by adipose tissue in obesity and that it is also involved in metabolic and inflammatory processes that underlie the development of obesity-related pathologies. This review provides a comprehensive summary of our current knowledge on the role of MIF in obesity, its production by adipose tissue, and its involvement in the development of insulin resistance, type 2 diabetes, and NAFLD. We discuss the main findings from recent clinical studies in obese subjects and weight-loss intervention studies as well as results from clinical studies in patients with insulin resistance and type 2 diabetes. Furthermore, we summarize findings from experimental disease models studying the contribution of MIF in obesity and insulin resistance, type 2 diabetes, and hepatic lipid accumulation and fibrosis. Although many of the findings support a pro-inflammatory role of MIF in disease development, recent reports also provide indications that MIF may exert protective effects under certain conditions.

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Section: Human Studiesmentioning

confidence: 99%

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Morrison

Kleemann

2015

Front. Immunol.

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“…Recent studies have found that MIF participates in the regulation of pregnancy and the occurrence of pathological pregnancy, because MIF was expressed in the placental trophoblast cells of GDM women (Enquobahrie et al, 2009). Serum MIF in GDM patients was significantly higher than that in the normal glucose tolerance group, and was significantly and positively correlated with FBG, FIN, and HOMA-IR levels during pregnancy (Yilmaz et al, 2012).…”

Section: Discussionmentioning

confidence: 78%

Association between macrophage migration inhibitory factor rs1007888 and GDM

Zhan¹,

Li²,

Chen³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the association between macrophage migration inhibitory factor (MIF) rs1007888 single-nucleotide polymorphisms and the genetic susceptibility to gestational diabetes mellitus (GDM). A total of 240 GDM pregnant women (GDM group) and 330 healthy pregnant women (control group) were included in the study. Differences in the MIF rs1007888 genotype and allele frequencies and differences between fasting blood glucose, fasting insulin, homeostatic model assessment (HOMA)-insulin resistance, and HOMA-b levels of pregnant women with different genotypes were compared. MIF genotype distributions were significantly different in the GDM group compared to the control group (P < 0.05). No significant difference was observed in the allele distributions of MIF rs1007888 between the GDM group and control group (P > 0.05). GDM patients had higher fasting blood glucose, fasting insulin, and HOMA-insulin resistance levels, but lower HOMA-b levels than normal gestational women (P < 0.05). Fasting blood glucose, fasting insulin, and HOMA-insulin resistance in pregnant women with the GG genotype were significantly higher than those with GA and AA genotypes, while HOMA-b in pregnant women with the GG genotype was lower (all P < 0.05). Our findings demonstrated the associations among MIF polymorphism rs1007888, insulin resistance, and pancreatic β cell functions in GDM patients. The GG genotype of MIF rs1007888 may be a genetic susceptibility factor in the pathogenesis of GDM.

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“…Furthermore, inhibition of MIF has been reported to decrease peripheral insulin resistance and to improve glucose profiles [25,26]. Individuals with GDM exhibit significantly elevated serum levels of MIF compared with healthy pregnant controls [17]. …”

Section: Discussionmentioning

confidence: 99%

“…Herder et al [16] reported a strong positive association between systemic concentrations of MIF and impaired glucose tolerance and T2D. In addition, studies have demonstrated that serum levels of MIF are significantly elevated in pregnant women with GDM [17]. These findings suggest that there is an association between MIF and the etiology and pathophysiology of GDM.…”

Section: Introductionmentioning

confidence: 99%

Association of Macrophage Migration Inhibitory Factor Polymorphisms with Gestational Diabetes Mellitus in Han Chinese Women

Qiao²,

Qi³

et al. 2015

Gynecol Obstet Invest

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Objective: The purpose of the study was to investigate the association between macrophage migration inhibitory factor (MIF) gene polymorphisms and gestational diabetes mellitus (GDM) in Han Chinese women. Methods: In this study, 915 unrelated pregnant women were recruited, among whom 430 had GDM and 485 served as controls. The rs755622 in the MIF gene (MIF-173G/C) was detected by the polymerase chain reaction Tm-shift genotyping method with fluorescence melting curve analysis. The associations of rs755622 in MIF variants with plasma glucose and insulin levels in the oral glucose tolerance test (OGTT) as well as with with blood fat levels were investigated. Results: The frequencies of genotypes and allele types of rs755622 in MIF were significantly different between women of the GDM and control groups (all p < 0.001). Moreover, the single nucleotide polymorphism (SNP) was significantly associated with increased glucose levels at 0, 60 and 120 min during the OGTT (all p < 0.0038) and with the increased homeostasis model assessment of insulin resistance (p < 0.001) in the GDM group. Conclusion: Genetic polymorphism of rs755622 in MIF is associated with increased risk of GDM and insulin resistance in Han Chinese women.

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Macrophage migration-inhibitory factor is elevated in pregnant women with gestational diabetes mellitus

Abstract: Our data demonstrated that serum levels of MIF are significantly elevated in patients with GDM. Our findings indicate that MIF might have a role in GDM; however, there is a need for further investigation.

Cited by 16 publications

References 35 publications

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

Association between macrophage migration inhibitory factor rs1007888 and GDM

Association of Macrophage Migration Inhibitory Factor Polymorphisms with Gestational Diabetes Mellitus in Han Chinese Women

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