Macrophage Phenotype in Combination with Tumor Microbiome Composition Predicts RCC Patients’ Survival: A Pilot Study

Ковалева, О. В.; Podlesnaya, P. A.; Sorokin, Maxim; Мочальникова, В В; Kataev, Vladimir; Khlopko, Yuriy A.; Плотников, А. О.; Стилиди, И. С.; Кушлинский, Н. Е.; Gratchev, Alexei

doi:10.3390/biomedicines10071516

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…For instance, bacteria of the Tenericutes type were present in ccRCC and papRCC tumors but absent in normal tissue and chromophobe tumors. Furthermore, bacteria phyla Gemmatimonadetes, Chloroflexi, Fusobacteria, Parcubacteria , and Verrucomicrobia were found only in samples from normal kidney tissue [ 13 ]. Analysis of alpha diversity and overall bacterial composition revealed significant differences.…”

Section: Resident Renal Microbiome In Norm and Pathologymentioning

confidence: 99%

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Resident Microbiome of Kidney Tumors

Kovaleva,

Podlesnaya,

Gratchev

2024

Oncol.Rev.

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Emerging research has uncovered the significance of microbiota in carcinogenesis, with specific bacterial infectious agents linked to around 15% of malignant tumors. This review is focused on the resident kidney microbiome, its composition, and alterations in various diseases. Recent studies have shown that bacteria can infiltrate the kidney, with differences between normal and tumor tissue. These studies have identified distinctive microorganisms unique to both conditions, hinting at their potential clinical relevance. Research into the kidney microbiome diversity reveals differences in tumor tissue, with specific taxa associated with different histological types. Notably, the alpha diversity indices suggest variations in bacterial content between tumor and normal tissue, offering insights into potential diagnostic and prognostic use of these markers. Better studied is the impact of the gut microbiome on therapy efficacy in malignant kidney tumors. Antibiotics, which can alter the gut microbiome, have been linked to survival outcomes in patients receiving targeted therapy and immunotherapy. The findings suggest that the uncontrolled use of antibiotics may not only contribute to bacterial resistance but also disrupt the normal microbiome, potentially influencing the development of oncological diseases. In-depth investigation into the resident kidney microbiome is essential for addressing fundamental and practical aspects of kidney tumor development.

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Section: Resident Renal Microbiome In Norm and Pathologymentioning

confidence: 99%

“…No significant qualitative or quantitative changes in the microbiome were identified as the tumor progressed. However, there was a trend towards decreased bacterial load with disease progression [ 13 ]. These findings partially disagree with the results obtained by Wang and others [ 6 ].…”

Section: Resident Renal Microbiome In Norm and Pathologymentioning

confidence: 99%

Resident Microbiome of Kidney Tumors

Kovaleva,

Podlesnaya,

Gratchev

2024

Oncol.Rev.

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“…The tumor microbiome It has been determined that microorganisms also reside in sites outside of the gut and other portals of entry [52,55,56], particularly in tumors, where they represent underappreciated environmental agents and can exert regulatory functions on the TME immune and inflammatory program [44]. Up to now, a tumor microbiome has been characterized in many tumor types, such as pancreas cancer [49,57], prostate cancer [58], breast cancer [59], melanoma [60], gastric cancer [61], thyroid cancer [62,63], renal cell carcinoma (RCC) [64], nasopharyngeal carcinoma (NPC) [65], lung cancer [66,67], and cutaneous T cell lymphoma (CTCL) [68,69] (Table 1); Nevertheless, because of its low biomass, the characterization of the intratumor bacterial colonies has remained challenging. More recently, comprehensive analysis of more than 1500 tumor microbiomes across seven cancer types, using a mixture of assays like next-generation sequencing coupled with and the most abundant bacteria in colorectal tumors belong to the Bacteroidetes and Firmicutes phyla [70].…”

Section: Positive and Negative Impacts Of The Tumor Microbiota On T C...mentioning

confidence: 99%

Potential links between the microbiota and T cell immunity determine the tumor cell fate

et al. 2023

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The central role of the microbiota as a pivotal factor regulating anti-tumor immune responses has recently been appreciated. Increasing evidence has put a spotlight on the connection of microbiota to T cells, by showing impaired effector and/or memory responses in germ-free (GF) mice or in the presence of dysbiotic communities, and association with tumor growth and overall survival (OS). These observations also have significant implications for anti-tumor therapy and vaccination, suggesting that the communication between T cells and the microbiota involves soluble mediators (microbiota-derived metabolites) that influence various functions of T cells. In addition, there is growing appreciation of the role of bacterial translocation into the peritumoral milieu from the intestinal tract, as well as of locally developed tumor microbial communities, spatially separated from the gut microbiota, in shaping the tumor microbiome. Collectively, these findings have added new support to the idea that tonic inputs mirroring the existence of tumor microbiome could regulate the function of tumor-infiltrating T cells and tissue-resident memory T (TRM) cells. In this review, we focus on recent advances and aspects of these active areas of investigation and provide a comprehensive overview of the unique mechanisms that play a pivotal role in the regulation of anti-tumor immunity by the microbiota, some of which could be of particular relevance for addressing problems caused by tumor heterogeneity. It is our hope that this review will provide a theoretical foundation for future investigations in this area.

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“…Одной из таких перспективных комбинаций может являться комплексная морфологическая оценка стромы в совокупности и бактериальной нагрузкой. Использование комплексного анализа клеточного и бактериального состава в опухоли предложено относительно недавно [53,54], однако набирает популярность [55][56][57] Дальнейшие исследования показали, что что повышенное содержание бактерий наблюдается в группах опухолей НМРЛ с высокой экспрессией iNOS в опухолевых клетках и высоким содержанием FoxP3+ стромальных Т-клеток. В целом добавление оценки общей бактериальной нагрузки в опухоли кардинально меняет картину выживаемости пациентов.…”

Section: комплексный анализ микробиома и воспалительного инфильтрата ...unclassified

“…В случае повышенной экспрессии iNOS высокая бактериальная нагрузка достоверно является благоприятным прогностическим фактором, в то время как повышенная бактериальная нагрузка при большом количестве FoxP3 клеток является, наоборот, маркером плохого прогноза [54]. Для почечно-клеточного рака также показана прогностическая значимость маркеров опухолевого микроокружения, например CD66b+ нейтрофилов в зависимости от общей бактериальной нагрузки опухолей [55].…”

Section: комплексный анализ микробиома и воспалительного инфильтрата ...unclassified

Состав И Фенотип Опухолевой Стромы Как Маркер Прогноза Заболевания

Ковалева¹,

Подлесная²,

Petrenko³

et al. 2022

Zlokač. opuholi

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Рассматривая микроокружение опухоли, исследователи отмечают большое количество типов клеток, его составляющих. Изучаются различные типы клеток, начиная от стромальных фибробластов и клеток иммунной системы, заканчивая эндотелиальными клетками и адипоцитами. Однако, несмотря на большое количество исследований, использование не стандартизированных маркеров стромальных клеток и подходов в оценке прогноза заболевания до сих пор не привели к их использованию в рутинной клинической практике. Для многих солидных опухолей неотъемлемой составляющей опухолевой стромы является резидентный микробиом, способный в значительной степени повлиять на характер активации иммунокомпетентных клеток микроокружения и анализ состава которого, на сегодняшний день также предлагается использовать в качестве прогностического маркера. В настоящем обзоре литературы проанализирована информация по микробиому и клеточному составу и фенотипу иммунологической составляющей опухолевой стромы новообразований легкого, механизмам их взаимодействия и влиянию этого взаимодействия на прогрессию опухоли. А также изучена возможность их использования для оценки прогноза заболевания и в качестве мишеней для терапии.

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Macrophage Phenotype in Combination with Tumor Microbiome Composition Predicts RCC Patients’ Survival: A Pilot Study

Cited by 9 publications

References 44 publications

Resident Microbiome of Kidney Tumors

Resident Microbiome of Kidney Tumors

Potential links between the microbiota and T cell immunity determine the tumor cell fate

Состав И Фенотип Опухолевой Стромы Как Маркер Прогноза Заболевания

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