Macrophagic myofasciitis: an infantile Italian case

Muzio, Antonio Di; Capasso, Margherita; Verrotti, Alberto; Trotta, Daniela; Lupo, S.; Pappalepore, N.; Manzoli, Claudia; Chiarelli, Francesco; Uncini, Antonino

doi:10.1016/j.nmd.2003.09.007

Cited by 18 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The single patient treated with steroids and IVIG in the series by Rivas et al recovered partially from his neuromuscular symptoms . Di Muzio et al reported an infant with MMF in whom prednisone therapy over a year resulted in progressive clinical improvement . However, as these are reports of single patients, long‐term follow‐up studies on a greater number of patients are necessary to establish the utility and efficacy of treatment with steroids and/or IVIG.…”

Section: Discussionmentioning

confidence: 99%

Childhood macrophagic myofasciitis: A series from the Indian subcontinent

et al. 2017

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Childhood macrophagic myofasciitis: A series from the Indian subcontinent

et al. 2017

View full text Add to dashboard Cite

show abstract

“…However, these patients rarely present with central nervous sytem (CNS) manifestations like multiple sclerosis in the form of a demyelinating disease (15). MMF in children is rare and only eleven children have been reported (3,(6)(7)(8)(9). Because of rarity of MMF in childhood, symptomatology in children is not completely known unlike that in adult patients.…”

Section: Discussionmentioning

confidence: 99%

“…This name MMF was coined by the French Study and Research Group on Acquired Dysimmunity-related Muscle Diseases (GERMMAD) for a putative inflammatory myopathy. To date, more than 130 cases have been reported, mostly from France (2) but a few also from other countries including USA, UK, Germany, Portugal, Spain, Italy (3)(4)(5)(6)(7) and, most recently, Israel (8). The majority of cases documented are adults with few exceptions (3,(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Macrophagic myofasciitis in a 3-month-old child

et al. 2015

View full text Add to dashboard Cite

Macrophagic myofasciitis (MMF) is a rare inflammatory myopathy which occurs after injection of aluminium-containing vaccines against hepatitis B virus (HBV), hepatitis A virus, and tetanus toxoid. Most of the cases reported are from France and are adult patients. We report a rare case of MMF in a 3-month-old male child of Indian origin. He was immunized for HBV at birth after which he developed generalized hypotonia, and central nervous system and peripheral nervous system manifestations at 1 month of age. Muscle biopsy showed typical features of MMF and aluminium could be detected in the muscle biopsy macrophages by ultrastructural examination and LAMMA technique. Our case is the youngest case of MMF and one of few from Asia. (J Pediatr Neurol 2004; 2(4): 225?229).

show abstract

“…Since vaccination with aluminium-containing vaccines, most often against hepatitis, but also tetanus, is not confi ned to adults but is increasingly applied in children, reports on MMF in children have accrued in recent times most often from outside France, i. e., six originating from Israel [15] , one from Italy [4] , one from France [1] , eight from the Middle East [5,11,18] , seven from Spain [17] , two from the United Kingdom [3] , one from Germany [5] , three from Brazil [10] and eight from the United States of America [9,12,13,19] . Carefully reading these individual descriptions discloses that few if any additional and then largely though not exclusively [11,13] non-specifi c, myopathological fi ndings have been reported in biopsy specimens containing the MMF lesion.…”

Section: Macrophagic Myofasciitis Plus (Distinct Types Of Muscular Dymentioning

confidence: 99%

Macrophagic Myofasciitis Plus (Distinct Types of Muscular Dystrophy)

et al. 2009

View full text Add to dashboard Cite

Macrophagic myofasciitis (MMF) is a well-known lesion following vaccination with aluminium-containing vaccines. It has abundantly been reported in adults and several times in children, often in single patients or in rather small cohorts. Only few of these published reports on children have shown distinct myopathology of another neuromuscular disease except for MMF. Indications for biopsy often were nondescript clinical features in children, such as hypotonia or delay in motor development but, apparently, never that of suspected MMF. Thus, in previous reports as well as in our two patients, encountering MMF in the biopsied tissue specimens was coincidental. Our two unrelated patients with MMF also had two separate types of muscular dystrophy, a merosinopathy and dystrophinopathy, showing a combination of myopathologically well-defined neuromuscular diseases, muscular dystrophies and MMF. Detecting such a combination of two separate conditions may, in the future, be rare when non-invasive techniques, e. g., genetic, will have replaced muscle biopsy in ascertaining hereditary neuromuscular conditions, especially in children.

show abstract

Macrophagic myofasciitis: an infantile Italian case

Cited by 18 publications

References 4 publications

Childhood macrophagic myofasciitis: A series from the Indian subcontinent

Childhood macrophagic myofasciitis: A series from the Indian subcontinent

Macrophagic myofasciitis in a 3-month-old child

Macrophagic Myofasciitis Plus (Distinct Types of Muscular Dystrophy)

Contact Info

Product

Resources

About