Macropolycyclic polyethers (cages) and related compounds

Novel Podands and Macrocycles with Diacetal (Tetraoxadecalin) Cores: Synthesis, Structure, Stereochemistry and Cation Inclusion

“…The next task consisted of using the above functionalized podands for the preparation of the desired macrocyclic systems. The most reasonable and general course to follow, after having ruled out nucleophilic substitution on b-acetalic centers, was the inverse one: namely, to have nucleophilic groups on the 2,6-TOD substituents attack the termini of any judiciously chosen spacer or bridging group, for example, of the (poly)glycolic acid dichloride type (11).…”

Synthesis of Trismacrocyclic and Macrotricyclic Compounds Possessing Structural Fragments of Aza- and Diazacrown Ethers, Cyclen and Cyclam via Pd-Catalyzed Amination Reactions

“…The fixed distance between the two cations induces cations interactions leading to unique electronic properties. [1,2] Two of us previously described several convenient methods for the synthesis of macrotricycles possessing two cyclen (1,4,7,10-tetraazacyclododecane) or cyclam (1,4,8,11-tetraazacyclotetradecane) moieties linked via two xylylene bridges. These 3-step approaches utilize either N 1 ,N 8 -ditosyl-N 4 -Boc-cyclam [3] or N-Boc-substituted dioxocyclen and dioxocyclam.…”

Synthesis of mixed‐donor azaoxathia macrocyclic tetraamides, acyclic polyether di/and tetraamides and their C‐pivot lariat derivatives

“…It has also been reported that macrocyclic ligands with amide functional groups as binding sites form strong and selective complexes with noble [15][16][17] and transition [18] metals. Moreover, macrocyclic tetraamides are of increasing interest in several fields such as valuable synthetic intermediates of azacrown [19], azaparacyclophanes [20] or macropolycyclic polyethers (cages) [21], artificial receptors of biological substrate [22], enzyme model [23] or synthetic enzymes (synzymes) [24], neutral ionophores for selective alkalineearth ions extraction [25], transport through a bulk membrane [26] or ion-selective electrode incorporated membrane [27], luminescent lanthanide probes [28], ligands for highly oxidizing transition metal complexes [29], linkers for distribution of donor chelating sites in binuclear complexes [30] and interlocking moieties in neutral catenanes [31]. Further modification involved the attachment of a flexible side arm, with extra potential metal ion coordination sites, to a crown-ether framework producing complexing agents known as lariat crown ethers [32].…”